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Images
Published: 01 December 2024
CARDIAC PARAGANGLIOMA Figure 9-31 CARDIAC PARAGANGLIOMA This primary cardiac paraganglioma infiltrates myocardium at lower right. More about this image found in CARDIAC PARAGANGLIOMA This primary cardiac paraganglioma infiltrates myoca...
Images
Published: 01 December 2024
PIGMENTED CARDIAC PARAGANGLIOMA Figure 9-27 PIGMENTED CARDIAC PARAGANGLIOMA A: Dark brown to black granules are present in the tumor cell cytoplasm. B: Electron micrograph shows the pigment in A corresponds to amorphous aggregates consistent with lipofuscin/neuromelanin. More about this image found in PIGMENTED CARDIAC PARAGANGLIOMA A: Dark brown to black granules are presen...
Images
in Familial and Syndrome-Related Pheochromocytoma and Paraganglioma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
SDH-DEFICIENT PARAGANGLIOMA Figure 10-5 SDH-DEFICIENT PARAGANGLIOMA A: This cardiac paraganglioma from a patient with a pathogenic SDHB variant has round nesting architecture, oncocytic cytology with abundant eosinophilic cytoplasm, and focal tendency to form pseudorosettes. B: SDHB immunohistochemistry is negative, with retained positivity in vascular endothelium serving as an internal positive control. More about this image found in SDH-DEFICIENT PARAGANGLIOMA A: This cardiac paraganglioma from a patient w...
Images
Published: 01 December 2024
COMPLEX OF MYXOMA AND SPOTTY PIGMENTATION Figure 4-22 COMPLEX OF MYXOMA AND SPOTTY PIGMENTATION A: A young girl with multiple pigmented lesions about the mouth. The patient also had a darkly pigmented lesion on the vulva, probably a blue nevus. B: Cutaneous myxoma on the breast of the same patie... More about this image found in COMPLEX OF MYXOMA AND SPOTTY PIGMENTATION A: A young girl with multiple pi...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... exhibits small intracytoplasmic vacuoles with flocculent content, which are a well-known characteristic of SDH-deficient renal cell carcinoma but extremely rare in SDH-deficient paraganglioma. PIGMENTED CARDIAC PARAGANGLIOMA Figure 9-27 PIGMENTED CARDIAC PARAGANGLIOMA A: Dark brown to black granules...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... disease PDE11A, PDE8B, PRKACA Isolated micronodular adrenal disease <1% — Carney complex and isolated familial PPNAD PRKAR1A (PDE11A, PDE8B rare) PPNAD (carcinoma in case reports) <1% Pituitary and thyroid tumors, cardiac myxomas, peripheral nerve sheath tumors...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... associated with major central nervous system (CNS) malformations, renal agenesis, and complex cardiac anomalies ( 4 ). Renal agenesis is sometimes associated with an adrenal gland of abnormal shape, which may be oval with a smooth contour. FUSION OF ADRENAL GLANDS Figure 2-3 FUSION OF ADRENAL...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... hypertension, headache, fatigue, and weakness. In contrast, when present, hypokalemia can be insidious without obvious cause. More florid forms may present with cardiac dysrhythmias, polydipsia, polyuria, cramping, headaches, and weakness ( 17 ). Laboratory findings include increased plasma aldosterone levels...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... cell tumors, or mucocutaneous pigmentation [ fig. 4-22 ]), investigation for possible cardiac myxoma, frequently multiple, is recommended to permit early detection and treatment. Additional but more rare manifestations in Carney complex include cardiomyopathy, colonic polyps and adenocarcinoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... SDH-DEFICIENT PARAGANGLIOMA A: This cardiac paraganglioma from a patient with a pathogenic SDHB variant has round nesting architecture, oncocytic cytology with abundant eosinophilic cytoplasm, and focal tendency to form pseudorosettes. B: SDHB immunohistochemistry is negative, with retained...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... as hibernoma, may be coincidental. Cardiomyopathy may occur in patients with prolonged catecholamine excess, causing arrhythmia and cardiac failure. Weight loss, ileus, abdominal distention, pain, and other features of increased adrenergic tone should all be considered as manifestations of pheochromocytoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... histology is illustrated in figure 12-9 . The child also had the Kasabach-Merritt syndrome with thrombocytopenic purpura and died of high output cardiac failure. Approximately 40 examples of primary adrenal angiosarcoma have been reported in English publications ( 29 ), one coexisting...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... Martucci VL , Emaminia A , del Rivero J , et al . Succinate dehydrogenase gene mutations in cardiac paragangliomas . Am J Cardiol 2015 ; 115 : 1753 - 9 . 29. Kameneva P , Artemov AV , Kastriti ME , et al . Single-cell transcriptomics of human embryos identifies...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-07
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...VIRAL MYOCARDITIS General Considerations, Including Etiology and Synonyms Myocarditis, inflammation of the heart muscle frequently associated with myocyte injury and cardiac dysfunction, can have various causes, including viral infection. An integral part of the definitive diagnosis...
Images
Published: 01 September 2024
BORRELIA BURGDORFERI SPIROCHETES Figure 15-9 BORRELIA BURGDORFERI SPIROCHETES Silver stain illustrates Borrelia burgdorferi spirochetes in cardiac tissue. (Courtesy of the CDC PHIL) More about this image found in BORRELIA BURGDORFERI SPIROCHETES Silver stain illustrates...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-16
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... by the formation of vegetations that are, in essence, infected thrombi attached to the endocardial surface. These may occur on native tissue, prosthetic cardiac valves, or other devices. Historically, endocarditis and its systemic complications have been recognized since the 19th century. Although most cases...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-29
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... or even life. About 20 percent of patients continue to be asymptomatic, but with various degrees of organ dysfunction. Approximately 10 percent become symptomatic after the indeterminate phase, with the majority showing cardiac involvement. Gastrointestinal disease is seen predominantly in patients...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-28
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., and arthralgia. Lymphadenopathy, bronchospasm, cough, and a pruritic rash are also observed. Some patients have features of vasculitis and nonspecific rheumatic symptoms. Individuals with cardiac sarcocystosis may have atrial enlargement and electrocardiogram (ECG) abnormalities. Laboratory abnormalities...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-01
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... infectious diseases with three common clinical presentations, i.e., neurologic, respiratory, and cardiac, identified an infectious agent in only 28 percent of cases ( 6 ). In most of these cases, infectious pathogens were identified by serology and molecular techniques ( Table 1-1 ). The spectrum...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-25
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... such as Cryptococcus spp, cytomegalovirus, mycobacteria, and Nocardia spp. If there is cardiac involvement, other causes of infectious and noninfectious myocarditis need to be considered. Congenital toxoplasmosis is a result of acute maternal infection during pregnancy and should be suspected in any infant...
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