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Figure 9-31
Published: 01 December 2024
CARDIAC PARAGANGLIOMA Figure 9-31 CARDIAC PARAGANGLIOMA This primary cardiac paraganglioma infiltrates myocardium at lower right. More about this image found in CARDIAC PARAGANGLIOMA This primary cardiac paraganglioma infiltrates myoca...
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Figure 9-27
Published: 01 December 2024
PIGMENTED CARDIAC PARAGANGLIOMA Figure 9-27 PIGMENTED CARDIAC PARAGANGLIOMA A: Dark brown to black granules are present in the tumor cell cytoplasm. B: Electron micrograph shows the pigment in A corresponds to amorphous aggregates consistent with lipofuscin/neuromelanin. More about this image found in PIGMENTED CARDIAC PARAGANGLIOMA A: Dark brown to black granules are presen...
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Figure 10-5
Published: 01 December 2024
SDH-DEFICIENT PARAGANGLIOMA Figure 10-5 SDH-DEFICIENT PARAGANGLIOMA A: This cardiac paraganglioma from a patient with a pathogenic SDHB variant has round nesting architecture, oncocytic cytology with abundant eosinophilic cytoplasm, and focal tendency to form pseudorosettes. B: SDHB More about this image found in SDH-DEFICIENT PARAGANGLIOMA A: This cardiac paraganglioma from a patient w...
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Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... exhibits small intracytoplasmic vacuoles with flocculent content, which are a well-known characteristic of SDH-deficient renal cell carcinoma but extremely rare in SDH-deficient paraganglioma. PIGMENTED CARDIAC PARAGANGLIOMA Figure 9-27 PIGMENTED CARDIAC PARAGANGLIOMA A: Dark brown to black granules...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... disease PDE11A, PDE8B, PRKACA Isolated micronodular adrenal disease <1% — Carney complex and isolated familial PPNAD PRKAR1A (PDE11A, PDE8B rare) PPNAD (carcinoma in case reports) <1% Pituitary and thyroid tumors, cardiac myxomas, peripheral nerve sheath tumors...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... associated with major central nervous system (CNS) malformations, renal agenesis, and complex cardiac anomalies ( 4 ). Renal agenesis is sometimes associated with an adrenal gland of abnormal shape, which may be oval with a smooth contour. FUSION OF ADRENAL GLANDS Figure 2-3 FUSION OF ADRENAL...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-03
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... hypertension, headache, fatigue, and weakness. In contrast, when present, hypokalemia can be insidious without obvious cause. More florid forms may present with cardiac dysrhythmias, polydipsia, polyuria, cramping, headaches, and weakness ( 17 ). Laboratory findings include increased plasma aldosterone levels...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... cell tumors, or mucocutaneous pigmentation [ fig. 4-22 ]), investigation for possible cardiac myxoma, frequently multiple, is recommended to permit early detection and treatment. Additional but more rare manifestations in Carney complex include cardiomyopathy, colonic polyps and adenocarcinoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... SDH-DEFICIENT PARAGANGLIOMA A: This cardiac paraganglioma from a patient with a pathogenic SDHB variant has round nesting architecture, oncocytic cytology with abundant eosinophilic cytoplasm, and focal tendency to form pseudorosettes. B: SDHB immunohistochemistry is negative, with retained...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... as hibernoma, may be coincidental. Cardiomyopathy may occur in patients with prolonged catecholamine excess, causing arrhythmia and cardiac failure. Weight loss, ileus, abdominal distention, pain, and other features of increased adrenergic tone should all be considered as manifestations of pheochromocytoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... histology is illustrated in figure 12-9 . The child also had the Kasabach-Merritt syndrome with thrombocytopenic purpura and died of high output cardiac failure. Approximately 40 examples of primary adrenal angiosarcoma have been reported in English publications ( 29 ), one coexisting...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
.... Martucci   VL , Emaminia   A , del Rivero   J , et al . Succinate dehydrogenase gene mutations in cardiac paragangliomas . Am J Cardiol   2015 ; 115 : 1753 - 9 . 29. Kameneva   P , Artemov   AV , Kastriti   ME , et al . Single-cell transcriptomics of human embryos identifies...
Images
Figure 15-9
Published: 01 September 2024
BORRELIA BURGDORFERI SPIROCHETES Figure 15-9 BORRELIA BURGDORFERI SPIROCHETES Silver stain illustrates Borrelia burgdorferi spirochetes in cardiac tissue. (Courtesy of the CDC PHIL) More about this image found in BORRELIA BURGDORFERI SPIROCHETES Silver stain illustrates...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-07
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... ). Electrocardiogram (ECG) findings include ST-segment elevations that can resemble myocardial infarction, but cardiac catheterization is typically normal. Presentation with a bundle branch block or the presence of Q waves is associated with a worse outcome, including death. Echocardiography can define the ventricular...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-16
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
...Table 16-2 CLINICAL AND ANCILLARY TEST FINDINGS IN INFECTIVE ENDOCARDITIS Clinical Features Test Results Fever >38°C Cardiac murmur Splenomegaly Petechia, splinter hemorrhages Osler nodes or Roth spots Metastatic infections (e.g., vertebral osteomyelitis) Arterial emboli (e.g...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-29
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... , Fuenmayor   C , Inglessis   I . Cardiac involvement is a constant finding in acute Chagas’ disease: a clinical, parasitological and histopathological study . Int J Cardiol   1997 ; 60 : 49 - 54 . 9. Otani   MM , Vinelli   E , Kirchhoff   LV , et al . WHO comparative evaluation...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-28
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... and, less frequently, cardiac muscle. Sarcocystis spp cysts are also found in smooth muscle of various organs, including the esophagus and larynx. Since most cases are asymptomatic, Sarcocystis spp are often found incidentally in skeletal muscle surrounding a cancer resection...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-01
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... 9 Respiratory 33 13 3 by PCR, 10 by serology 4 9 Cardiac 22 3 1 by PCR, 2 by serology 1 2 Multisystem 15 3 2 by PCR, 1 by serology 2 1 Hepatic 8 0 0 0 Other 7 0 0 0 All cases 122 34 13 21 a Serology includes enzyme immune assay or indirect...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-25
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... circinate rash. There may also be malaise, weakness, anorexia, and weight loss, associated with anemia, leukocytosis, and a strikingly raised erythrocyte sedimentation rate (ESR). Hypergammaglobulinemia (especially IgM) due to polyclonal B-cell activation is characteristic. Cardiac involvement is frequent...