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carcinosarcoma
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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... identify these other lesions. Moreover, especially in cytologic samples, myxoid adrenal cortical carcinomas may be misdiagnosed as mucinous adenocarcinomas. Sarcomatoid ACC. Formerly named carcinosarcoma, sarcomatoid ACC is very rare, with less than 30 cases reported in the literature ( 135 ). Most cases...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... D , et al . Metaplastic breast carcinomas are basal-like tumours . Histopathology 2006 ; 49 : 10 - 21 . 204. Moukarzel LA , Ferrando L , Da Cruz Paula A , et al . The genetic landscape of metaplastic breast cancers and uterine carcinosarcomas . Mol Oncol 2021 ; 15...
Images
Published: 01 August 2023
CARCINOSARCOMA Figure 5-17 CARCINOSARCOMA The epithelial component of carcinosarcoma can predominate but the presence of a malignant stromal component (at left) establishes the diagnosis of carcinosarcoma. More about this image found in CARCINOSARCOMA The epithelial component of carcinosarcoma can predominate ...
Images
Published: 01 August 2023
CARCINOSARCOMA OF FALLOPIAN TUBE Figure 16-36 CARCINOSARCOMA OF FALLOPIAN TUBE High grade epithelial and mesenchymal components. More about this image found in CARCINOSARCOMA OF FALLOPIAN TUBE High grade epithelial and mesenchymal com...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch56
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... prognosis in soft tissue synovial sarcoma. Differential Diagnosis. The differential diagnosis includes undifferentiated sarcoma and, in the case of biphasic tumors, carcinosarcoma and malignant mesothelioma. Because of the monomorphic appearance of the spindle cells, imparting a monotonous and densely...
Images
in Other Carcinomas, Miscellaneous Tumors, and Tumor-Like Conditions
> Tumors of the Ovary and Fallopian Tube
Published: 01 August 2023
MESONEPHRIC-LIKE CARCINOMA Figure 14-1 MESONEPHRIC-LIKE CARCINOMA A: Tubulocystic and focally solid growth. B: Low columnar cells with eosinophilic secretions. C,D: Mesonephric-like carcinosarcoma. More about this image found in MESONEPHRIC-LIKE CARCINOMA A: Tubulocystic and focally solid growth. B: L...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-14
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... Carcinosarcoma of the ovary Mixed carcinoma of the ovary Miscellaneous Tumors Mesonephric-like carcinoma Rete cystadenoma, adenoma, and adenocarcinoma Wolffian tumor of the ovary Solid pseudopapillary tumor Small cell carcinoma of the ovary, hypercalcemic type Wilms tumor...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-11
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... muscle and negative for sex cord-stromal markers, such as SF1, inhibin, FOXL2, and calretinin. A carcinosarcoma in which the carcinomatous component has not been identified could resemble a leiomyosarcoma. In this situation, it is imperative that sufficient material is taken for assessment...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-05
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... TO HIGH-GRADE CARCINOMA This serous borderline tumor (A), has progressed to higher grade carcinoma with both papillary (B) and solid (C) architecture. The epithelial component of carcinosarcoma can be serous in type ( fig. 5-17 ), and show the immunophenotype of high-grade serous carcinoma (e.g. WT1...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-02
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
.... Clear cell carcinomas, carcinosarcomas, and de-/undifferentiated carcinomas are not formally graded, but they are intrinsically high grade. Table 2-1 GRADING SYSTEMS CURRENTLY EMPLOYED IN OVARIAN CARCINOMA Tumor Histotype Grading System Endometrioid Recommended: FIGO Grade 1: <5...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-16
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... panel; this is characteristic of HPV-associated endocervical carcinoma, but it is not diagnostic. Carcinosarcoma (Malignant Mixed Mullerian Tumor) and Clear Cell, Mucinous, and Undifferentiated Carcinomas of the Fallopian Tube Clear cell ( 6 , 10 ), mucinous ( 10...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-07
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... resembling endometrial stroma surrounding characteristic epithelial glands; and 3) the exclusion of a second malignant tumor metastatic to the ovary. Many pathologists have now loosened these criteria to include the development of endometrioid or clear cell carcinoma, carcinosarcoma (malignant mixed...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-03
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
..., and with the use of NGS panels, all five genes can be sequenced at the time of initial investigation. Microscopic Findings and Mutational Analysis. Almost all Lynch syndrome-associated ovarian carcinomas are endometrioid, clear cell, undifferentiated, or mixtures thereof. A rare MSI-H carcinosarcoma can also...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-13
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... an immature or maturing appearance. This should not be classified as immature when the tissue is organized and organoid and mitoses and apoptosis are lacking. Carcinosarcoma arising in the ovary shows malignant epithelial and mesenchymal components. These are not associated with other teratomatous...
Images
Published: 01 February 2023
CARCINOSARCOMA Figure 3-56 CARCINOSARCOMA This malignant neoplasm is composed of a high-grade adenocarcinoma admixed with distinct malignant mesenchymal elements, in this case with cartilaginous differentiation. More about this image found in CARCINOSARCOMA This malignant neoplasm is composed of a high-grade adenoca...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-08
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... of adenocarcinoma that produces a biphasic appearance were previously designated carcinosarcomas. Because this entity includes a spectrum of morphologies, we recommend the inclusion of pertinent descriptors when diagnosing an undifferentiated carcinoma. Undifferentiated carcinomas containing osteoclast-like giant...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-3
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... considering the exceedingly rare instance of carcinosarcoma of the cervix, several other entities must be excluded such as spindle cell SCC, mesonephric carcinoma with a spindle cell component, and cervical involvement by an endometrial carcinosarcoma. Trophoblastic neoplasia, particularly epithelioid...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-4
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... of mesonephric carcinoma with a spindle cell component featuring severe cytologic atypia and brisk proliferation; in this situation, the term mesonephric carcinosarcoma has been used ( 99 – 101 ). Heterologous sarcomatous elements and negative staining for epithelial markers are supporting features...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-2
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
..., HPV-independent, gastric type Adenocarcinoma, HPV-independent, clear cell type Adenocarcinoma, HPV-independent, mesonephric type Other adenocarcinomas Other epithelial tumors Carcinosarcoma Adenosquamous and mucoepidermoid carcinomas Adenoid basal carcinoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-5
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... periurethra, left labium, and hymen ( 185 ). Histologically, the tumor can show villoglandular growth, as well as variable mucinous differentiation in the form of goblet cells, prominent mucin extravasation, and signet ring cell morphology. A vulvar carcinosarcoma with an intestinal-type mucinous...
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