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carcinoma

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...Invasive breast carcinoma is a broad category of epithelial malignancies, most with overlapping clinical and imaging characteristics, as well as macroscopic features, but each with varied microscopic features. It is these latter characteristics that are used to classify breast carcinomas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in the potential for diagnostic confusion with skin adnexal (sebaceous or sweat gland) neoplasms, metastatic renal cell carcinoma, or xanthomatous histiocytic proliferations. DEEP PENETRATING NEVUS-LIKE (PLEXIFORM) MELANOMA Some melanomas may be confused with, or arise in association with, a deep penetrating...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and only clinical manifestation of metastatic melanoma of unknown primary. A metastasis may present as a pigmented or amelanotic papule or nodule. It may be confused with a nevus, primary melanoma, or nonmelanocytic lesion (e.g., carcinoma, angioma, lipoma, cyst) ( 1 – 3 ). When the metastatic deposit...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... syndrome, with risk for ocular melanoma, mesothelioma, renal cell carcinoma, and other neoplasms ( Table 10-2 ) ( 11 ). Microscopic features suggestive of a germline mutation include the presence of junctional nests with BAP1 loss and fatty metaplasia of dermal melanocytes. Some BAP1-inactivated nevi show...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... ). Lesions are suspicious for nodular melanoma if they are elevated, firm, and progressively growing. However, these parameters have limited sensitivity and specificity. Amelanotic nodular melanoma may be confused with a range of other lesions, such as basal cell carcinoma, dermatofibroma, cyst...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., especially if there was a prior diagnosis of lentigo maligna. The clinical recognition of DM without pigment background is very challenging. Dermoscopic features are of limited value ( 12 ). Amelanotic DM may be confused with a scar, fibroma, cyst, or keratinocyte (basal cell or squamous cell) carcinoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...  Dysplastic nevus  Traumatized nevus  Congenital nevus  Pagetoid carcinomas (extramammary Paget disease, pagetoid squamous cell carcinoma in situ, sebaceous carcinoma in situ) Molecular Genetic Findings  Cytogenetic aberrations detectable by FISH or CGH/SNP array are common  Most common...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... lentigo, lichenoid keratosis, pigmented seborrheic or pigmented actinic keratosis, or pigmented squamous cell carcinoma in situ. Some lesions of LM present clinically as an erythematous patch. LENTIGO MALIGNA Figure 13-1 LENTIGO MALIGNA A: Irregular pigmented patch on the cheek of an elderly woman. B...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...., of the cervix or colon), an evolutionary “premalignant” process was referred to as “dysplasia,” from which carcinoma could develop. Accordingly, the dysplastic nevus was proposed by Clark and Elder ( 6 ) as an intermediate step lesion between ordinary nevus and melanoma. CLINICAL FEATURES Dysplastic nevi tend...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-03
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of ectatic blood vessels ( fig. 3-20 ). Clinically, these lesions may simulate a basal cell carcinoma or angioma. Nevi may also collide with a true hemangioma. ANGIOMATOID MELANOCYTIC NEVUS Figure 3-20 ANGIOMATOID MELANOCYTIC NEVUS A: Superficial plaque-like growth of intradermal melanocytes is associated...
Images
LOBULAR <span class="search-highlight">CARCINOMA</span> IN SITU AND LOW NUCLEAR GRADE DUCTAL <span class="search-highlight">CARCINOMA</span> IN SITU AN...
Published: 01 January 2024
LOBULAR CARCINOMA IN SITU AND LOW NUCLEAR GRADE DUCTAL CARCINOMA IN SITU AND/OR ATYPICAL DUCTAL HYPERPLASIA (SOLID PATTERN) Figure 4-11 LOBULAR CARCINOMA IN SITU AND LOW NUCLEAR GRADE DUCTAL CARCINOMA IN SITU AND/OR ATYPICAL DUCTAL HYPERPLASIA (SOLID PATTERN) These can be difficult to distinguish... More about this image found in LOBULAR CARCINOMA IN SITU AND LOW NUCLEAR GRADE DUCTAL CARCINOMA IN SITU AN...
Images
PLEOMORPHIC LOBULAR <span class="search-highlight">CARCINOMA</span> IN SITU AND MICROINVASIVE <span class="search-highlight">CARCINOMA</span>  A lobule...
Published: 01 January 2024
PLEOMORPHIC LOBULAR CARCINOMA IN SITU AND MICROINVASIVE CARCINOMA Figure 4-18 PLEOMORPHIC LOBULAR CARCINOMA IN SITU AND MICROINVASIVE CARCINOMA A lobule is expanded by atypical, dyshesive epithelial cells with large pleomorphic nuclei. Present in the stroma adjacent to this focus are several scat... More about this image found in PLEOMORPHIC LOBULAR CARCINOMA IN SITU AND MICROINVASIVE CARCINOMA A lobule...
Images
INVASIVE DUCTAL <span class="search-highlight">CARCINOMA</span>  A: At low power, this <span class="search-highlight">carcinoma</span>, composed of sma...
Published: 01 January 2024
INVASIVE DUCTAL CARCINOMA Figure 6-9 INVASIVE DUCTAL CARCINOMA A: At low power, this carcinoma, composed of small glands, is arranged in multiple nodular areas, reminiscent of sclerosing adenosis. B: At intermediate power, the nodules still appear relatively well circumscribed, although some nes... More about this image found in INVASIVE DUCTAL CARCINOMA A: At low power, this carcinoma, composed of sma...
Images
INVASIVE <span class="search-highlight">CARCINOMA</span>  A: Low-grade invasive ductal <span class="search-highlight">carcinoma</span> with a relativel...
Published: 01 January 2024
INVASIVE CARCINOMA Figure 6-10 INVASIVE CARCINOMA A: Low-grade invasive ductal carcinoma with a relatively circumscribed growth pattern can be misinterpreted as sclerosing adenosis. B: At higher power, the glands appear more disorganized than would be expected in sclerosing adenosis. In addition... More about this image found in INVASIVE CARCINOMA A: Low-grade invasive ductal carcinoma with a relativel...
Images
SOLID PAPILLARY <span class="search-highlight">CARCINOMA</span>  A: Low-power image of solid papillary <span class="search-highlight">carcinoma</span> ...
Published: 01 January 2024
SOLID PAPILLARY CARCINOMA Figure 7-27 SOLID PAPILLARY CARCINOMA A: Low-power image of solid papillary carcinoma with solid, rounded nests and a delicate fibrovascular network. B,C: At intermediate (B) and high (C) power, the monomorphic cytology and cribriform architecture within the rounded nes... More about this image found in SOLID PAPILLARY CARCINOMA A: Low-power image of solid papillary carcinoma ...
Images
INVASIVE DUCTAL <span class="search-highlight">CARCINOMA</span> AND SOLID PAPILLARY <span class="search-highlight">CARCINOMA</span> (IN SITU)  A: At lo...
Published: 01 January 2024
INVASIVE DUCTAL CARCINOMA AND SOLID PAPILLARY CARCINOMA (IN SITU) Figure 7-31 INVASIVE DUCTAL CARCINOMA AND SOLID PAPILLARY CARCINOMA (IN SITU) A: At low power, much of the tumor is arranged in large, solid, rounded nests, with a papillary architecture. However, small foci of conventional invasiv... More about this image found in INVASIVE DUCTAL CARCINOMA AND SOLID PAPILLARY CARCINOMA (IN SITU) A: At lo...
Images
INVASIVE <span class="search-highlight">CARCINOMA</span>  In this case of solid papillary <span class="search-highlight">carcinoma</span> with mucin pr...
Published: 01 January 2024
INVASIVE CARCINOMA Figure 7-32 INVASIVE CARCINOMA In this case of solid papillary carcinoma with mucin production, there are areas of conventional invasive ductal carcinoma (upper left of field), as well as areas with mucinous differentiation (lower left of field). More about this image found in INVASIVE CARCINOMA In this case of solid papillary carcinoma with mucin pr...
Images
INVASIVE DUCTAL <span class="search-highlight">CARCINOMA</span> AND DUCTAL <span class="search-highlight">CARCINOMA</span> IN SITU (DCIS)  A: Frequentl...
Published: 01 January 2024
INVASIVE DUCTAL CARCINOMA AND DUCTAL CARCINOMA IN SITU (DCIS) Figure 8-17 INVASIVE DUCTAL CARCINOMA AND DUCTAL CARCINOMA IN SITU (DCIS) A: Frequently, DCIS is seen admixed and/or surrounding invasive breast carcinomas. The DCIS is recognizable as having more rounded tumor cell nests. B: High-pow... More about this image found in INVASIVE DUCTAL CARCINOMA AND DUCTAL CARCINOMA IN SITU (DCIS) A: Frequentl...
Images
INVASIVE LOBULAR <span class="search-highlight">CARCINOMA</span>  A: At low power, invasive lobular <span class="search-highlight">carcinoma</span> wit...
Published: 01 January 2024
INVASIVE LOBULAR CARCINOMA Figure 8-35 INVASIVE LOBULAR CARCINOMA A: At low power, invasive lobular carcinoma with low nuclear grade can resemble chronic inflammation. B: Higher-power examination reveals the epithelial nature of the cells as well as the characteristic cytologic features. More about this image found in INVASIVE LOBULAR CARCINOMA A: At low power, invasive lobular carcinoma wit...
Images
TUBULAR <span class="search-highlight">CARCINOMA</span>  A: Tubular <span class="search-highlight">carcinoma</span> with stromal desmoplasia and elasto...
Published: 01 January 2024
TUBULAR CARCINOMA Figure 8-44 TUBULAR CARCINOMA A: Tubular carcinoma with stromal desmoplasia and elastosis. B: Focus of flat epithelial atypia is present at the lower portion of the field. C: At higher power, the cytologic similarity of the cells in the flat epithelial atypia (lower left) and ... More about this image found in TUBULAR CARCINOMA A: Tubular carcinoma with stromal desmoplasia and elasto...