UNDIFFERENTIATED CARCINOMA WITH RHABDOID FEATURES Figure 8-17 UNDIFFERENTIATED CARCINOMA WITH RHABDOID FEATURES A: This carcinoma has rhabdoid features. B,C: Immuno labeling for CK19 is positive (B), while INI1 is lost (C). More

ACINAR CELL CARCINOMA Figure 9-3 ACINAR CELL CARCINOMA A: Acinar cell carcinoma arising in the head of the pancreas with polypoid extension into the duodenum. B: The neoplasm is tan to pink and circumscribed, and shows focal hemorrhage. C: This 15-cm tumor shows a central degenerative cyst. More

MIXED ACINAR-DUCTAL CARCINOMA Figure 9-47 MIXED ACINAR-DUCTAL CARCINOMA A: The mucinous acinar cell carcinoma pattern has a solid appearance, with regions closely resembling acinar cell carcinoma, but the periphery of the neoplasm has intracellular mucin. B: There is expression of trypsin (brown... More

MIXED ACINAR-DUCTAL CARCINOMA Figure 9-48 MIXED ACINAR-DUCTAL CARCINOMA A: The mucinous acinar cell carcinoma pattern has nests of uniform cells with acinar features surrounded by abundant desmoplastic stroma with focal stromal mucin accumulation. B: The acinar component has granular apical cyto... More

ACINAR CELL CARCINOMA Figure 9-5 ACINAR CELL CARCINOMA Top: At low power, acinar cell carcinomas are circumscribed and surrounded by a fibrous pseudocapsule into which mushroom-like projections may grow. Bottom: Rarely, there is polypoid growth into the pancreatic ducts; non-neoplastic ductal ep... More

ACINAR CELL CARCINOMA Figure 9-29 ACINAR CELL CARCINOMA Acinar cell carcinomas can lack nucleoli and show anisonucleosis and rare signet ring-like cells (Papanicolaou stain). More

MIXED ACINAR-NEUROENDOCRINE CARCINOMA Figure 9-45 MIXED ACINAR-NEUROENDOCRINE CARCINOMA Smears of mixed acinar neuroendocrine carcinomas are highly cellular, similar to pure acinar cell carcinomas. Atypical plasmacytoid cells with granular cytoplasm appear singly dispersed (Diff Quik). More

METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Figure 14-2 METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Histology of a nodular metastasis of renal cell carcinoma (left). Nests of clear cell carcinoma extend adjacent to non-neoplastic islet cells (right). More

ACINAR CELL CARCINOMA Figure 9-31 ACINAR CELL CARCINOMA Immunolabeling for trypsin in a smear of acinar cell carcinoma. More

COLLOID CARCINOMA Figure 8-9 COLLOID CARCINOMA An intestinal-type intraductal papillary mucinous neoplasm (center and top) has an associated invasive colloid carcinoma (bottom). More

MIXED ACINAR-NEUROENDOCRINE CARCINOMA Figure 9-38 MIXED ACINAR-NEUROENDOCRINE CARCINOMA The neoplasm is solid and fleshy, with minimal fibrous stroma, similar to acinar cell carcinomas. More

INTRADUCTAL TUBULOPAPILLARY NEOPLASM WITH ASSOCIATED INVASIVE CARCINOMA Figure 6-59 INTRADUCTAL TUBULOPAPILLARY NEOPLASM WITH ASSOCIATED INVASIVE CARCINOMA Left: Irregular and angulated glands infiltrate the periductal stroma, with associated stromal reaction (inset). Right: Subtle nests and str... More

COLLOID CARCINOMA Figure 8-6 COLLOID CARCINOMA Left: On cross section, large gelatinous areas are embedded in the stroma (lower half). An area of cystic degeneration is present (top). Right: Gelatinous colloid carcinoma in the head of the pancreas. An associated intraductal papillary mucinous ne... More

METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Figure 14-4 METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Air-dried Romanowsky-stained smears enhance the appearance of microvesicles in the abundant cytoplasm of renal cell carcinoma (left), juxtaposed with comparatively small non-neoplastic ac... More

PANCREATIC NEUROENDOCRINE CARCINOMA, LARGE CELL TYPE Figure 12-86 PANCREATIC NEUROENDOCRINE CARCINOMA, LARGE CELL TYPE Left: KRAS and TP53 mutations were present in this high-grade neuroendocrine carcinoma with large, atypical nuclei and moderately abundant cytoplasm. Right: Large cells with irregular nuclei and coarse chromatin (left: H&E stain; right: Papanicolaou stain). More

METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE, INVOLVING WELL-DIFFERENTIATED NEUROENDOCRINE TUMOR Figure 14-6 METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE, INVOLVING WELL-DIFFERENTIATED NEUROENDOCRINE TUMOR The renal cell carcinoma (top) has clear cell features whereas the neuroendocrine t... More