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carcinoma
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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Adrenal cortical carcinoma (ACC) is a malignant neoplasm originating from the steroidogenic epithelial cells of the adrenal cortex. EPIDEMIOLOGY ACC accounts for the majority of deaths attributable to primary adrenal neoplasia, but it is a rare disease, meeting the criteria for an “orphan...
Images
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA Figure 6-2 ADRENAL CORTICAL CARCINOMA This adrenal cortical carcinoma shows a gross nodule-in-nodule appearance (A). Peripheral areas are well circumscribed with oncocytic features (B). A thin capsule (C) separates the peripheral areas from a central component with an a... More about this image found in ADRENAL CORTICAL CARCINOMA This adrenal cortical carcinoma shows a gross n...
Images
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA Figure 6-7 ADRENAL CORTICAL CARCINOMA A large adrenal cortical carcinoma (ACC) from a 57-year-old woman simulated a renal cell carcinoma. The patient had no recognizable endocrine syndrome. Over half of the neoplasm was necrotic. More about this image found in ADRENAL CORTICAL CARCINOMA A large adrenal cortical carcinoma (ACC) from a...
Images
in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND Figure 12-26 HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND A: Hepatocellular carcinoma metastatic to the adrenal gland can simulate a primary adrenal cortical carcinoma. This metastasis has a prominent trabecular pattern with delicate si... More about this image found in HEPATOCELLULAR CARCINOMA METASTATIC TO ADRENAL GLAND A: Hepatocellular car...
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in Other Adrenal Neoplasms and Tumor-Like Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
RENAL CELL CARCINOMA METASTATIC TO ADRENAL GLAND Figure 12-27 RENAL CELL CARCINOMA METASTATIC TO ADRENAL GLAND A: Adrenal metastasis from an ipsilateral renal cell carcinoma. The patient had undergone radical nephrectomy for a large renal cell carcinoma. Metastatic clear cell renal carcinoma is p... More about this image found in RENAL CELL CARCINOMA METASTATIC TO ADRENAL GLAND A: Adrenal metastasis fro...
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Published: 01 December 2024
SF1 IN ADRENAL CORTICAL CARCINOMA Figure 6-31 SF1 IN ADRENAL CORTICAL CARCINOMA The diagnosis of metastatic adrenal cortical carcinoma in this transbronchial fine needle aspiration biopsy of a perihilar lymph node (A) is supported by positive nuclear staining for SF1 (B). More about this image found in SF1 IN ADRENAL CORTICAL CARCINOMA The diagnosis of metastatic adrenal cort...
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Published: 01 December 2024
ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOMA AND CARCINOMA Figure 5-31 ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOMA AND CARCINOMA A diagnosis of adrenal cortical carcinoma was suspected because of the presence of predominant oncocyti... More about this image found in ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOM...
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Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA ARISING IN ADRENAL CORTICAL ADENOMA Figure 6-1 ADRENAL CORTICAL CARCINOMA ARISING IN ADRENAL CORTICAL ADENOMA A: Transition from adenomatous areas to carcinoma within the same lesion (from bottom to top). B,C: Carcinomatous areas have atypical eosinophilic cells with n... More about this image found in ADRENAL CORTICAL CARCINOMA ARISING IN ADRENAL CORTICAL ADENOMA A: Transiti...
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in Hereditary Predisposition to Adrenal Cortical Lesions
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA IN A YOUNG PATIENT WITH LI-FRAUMENI SYNDROME Figure 7-8 ADRENAL CORTICAL CARCINOMA IN A YOUNG PATIENT WITH LI-FRAUMENI SYNDROME Nine-month-old boy with 8-cm right adrenal tumor. No signs of hormonal overproduction. Resection specimen shows nuclear pleomorphism and incre... More about this image found in ADRENAL CORTICAL CARCINOMA IN A YOUNG PATIENT WITH LI-FRAUMENI SYNDROME Ni...
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Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA Figure 6-3 ADRENAL CORTICAL CARCINOMA Computerized tomography (CT) scan of a 10-cm lesion in the right adrenal gland adjacent to liver. A: Basal uptake (>20 HU) with poorly defined separation from the liver. B: Heterogeneous uptake in the venous phase. (Courtesy of... More about this image found in ADRENAL CORTICAL CARCINOMA Computerized tomography (CT) scan of a 10-cm le...
Images
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA Figure 6-4 ADRENAL CORTICAL CARCINOMA This 19-cm adrenal lesion in the left adrenal gland has marked intratumoral heterogeneity. Upper panels: CT scan. Basal (A, >20 HU); heterogeneous uptake in the venous (B) and arterial (C) phases. Lower panels: MRI scan. T2 phase... More about this image found in ADRENAL CORTICAL CARCINOMA This 19-cm adrenal lesion in the left adrenal g...
Images
Published: 01 December 2024
ONCOCYTIC ADRENAL CORTICAL CARCINOMA Figure 6-5 ONCOCYTIC ADRENAL CORTICAL CARCINOMA CT scan of 10-cm adrenal lesion. Basal (20 HU), clearly defined borders (A); poor and heterogeneous uptake in the venous (B) and arterial (C) phases. (Courtesy of Prof. A. Veltri and Dr. F. Solitro, San Luigi Hos... More about this image found in ONCOCYTIC ADRENAL CORTICAL CARCINOMA CT scan of 10-cm adrenal lesion. Basa...
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Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA ARISING IN ADRENAL CORTICAL ADENOMA Figure 6-6 ADRENAL CORTICAL CARCINOMA ARISING IN ADRENAL CORTICAL ADENOMA This adrenal lesion, 11 cm in size (same case as shown in fig. 6-1 ), has two distinct areas: a benign one with <10 HU and the malignant one at 30 HU. (A: C... More about this image found in ADRENAL CORTICAL CARCINOMA ARISING IN ADRENAL CORTICAL ADENOMA This adrena...
Images
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA Figure 6-8 ADRENAL CORTICAL CARCINOMA An ACC from a 32-year-old female weighed 2,200 g and measured 21 cm in diameter. There were extensive areas of necrosis with foci of vascular invasion. The patient also had pulmonary metastases at the time of diagnosis. More about this image found in ADRENAL CORTICAL CARCINOMA An ACC from a 32-year-old female weighed 2,200 ...
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Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA Figure 6-9 ADRENAL CORTICAL CARCINOMA This large ACC was resected from a 27-year-old woman with virilization. The tumor measured 17 cm in diameter and invaded both kidney and spleen, which necessitated en bloc removal of these organs along with the tumor. More about this image found in ADRENAL CORTICAL CARCINOMA This large ACC was resected from a 27-year-old ...
Images
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA Figure 6-10 ADRENAL CORTICAL CARCINOMA Heterogeneous cut surface with irregular lobulation, and areas of hemorrhage and necrosis. More about this image found in ADRENAL CORTICAL CARCINOMA Heterogeneous cut surface with irregular lobula...
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Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA: ARCHITECTURAL PATTERNS Figure 6-11 ADRENAL CORTICAL CARCINOMA: ARCHITECTURAL PATTERNS Tumor architecture may be extremely variable, with patterns including the solid (A), “insular” (B), or large trabecular (C), frequently present within the same lesion. More about this image found in ADRENAL CORTICAL CARCINOMA: ARCHITECTURAL PATTERNS Tumor architecture may ...
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Published: 01 December 2024
NECROSIS IN ADRENAL CORTICAL CARCINOMA Figure 6-12 NECROSIS IN ADRENAL CORTICAL CARCINOMA Necrotic areas may be focal punctate (A) or extensive (B), in some cases involving most of the tumor (C). More about this image found in NECROSIS IN ADRENAL CORTICAL CARCINOMA Necrotic areas may be focal punctat...
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Published: 01 December 2024
NECROSIS IN ADRENAL CORTICAL CARCINOMA Figure 6-13 NECROSIS IN ADRENAL CORTICAL CARCINOMA Calcifications may occur in extensive necrotic areas. More about this image found in NECROSIS IN ADRENAL CORTICAL CARCINOMA Calcifications may occur in extensi...
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Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA Figure 6-14 ADRENAL CORTICAL CARCINOMA In most cases, a population of eosinophilic lipid-poor cells predominates (A), with irregular nuclei and prominent nucleoli (B). More about this image found in ADRENAL CORTICAL CARCINOMA In most cases, a population of eosinophilic lip...
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