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carcinoma

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MEDULLARY THYROID <span class="search-highlight">CARCINOMA</span>  Left: Medullary thyroid <span class="search-highlight">carcinoma</span> is composed ...
Published: 01 November 2022
MEDULLARY THYROID CARCINOMA Figure 3-40 MEDULLARY THYROID CARCINOMA Left: Medullary thyroid carcinoma is composed of spindle and epithelioid cells. Right: Calcitonin immunostain is strong in the tumor cells. More
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ADRENAL INSUFFICIENCY SECONDARY TO METASTATIC <span class="search-highlight">CARCINOMA</span>  Histologic examina...
Published: 01 November 2022
ADRENAL INSUFFICIENCY SECONDARY TO METASTATIC CARCINOMA Figure 4-14 ADRENAL INSUFFICIENCY SECONDARY TO METASTATIC CARCINOMA Histologic examination shows a deposit of metastatic adenocarcinoma with a thin rim of residual adrenal cortical tissue. More
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GRAVES DISEASE  There may be such marked papillary hyperplasia that the dia...
Published: 01 November 2022
GRAVES DISEASE Figure 3-27 GRAVES DISEASE There may be such marked papillary hyperplasia that the diagnosis of papillary thyroid carcinoma is considered. Careful attention to the nuclear features helps avoid this pitfall. More
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ECTOPIC THYROID TISSUE  Left: Ectopic thyroid tissue in a thyroglossal duct...
Published: 01 November 2022
ECTOPIC THYROID TISSUE Figure 3-8 ECTOPIC THYROID TISSUE Left: Ectopic thyroid tissue in a thyroglossal duct remnant shows colloid follicles with cuboidal epithelium. Right: This tissue may be mistaken for metastatic thyroid carcinoma; however, the cytologic features are benign. More
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C-CELL HYPERPLASIA  C-cell hyperplasia and microscopic medullary thyroid ca...
Published: 01 November 2022
C-CELL HYPERPLASIA Figure 3-39 C-CELL HYPERPLASIA C-cell hyperplasia and microscopic medullary thyroid carcinoma in a patient with multiple endocrine neoplasia (MEN) type 2B. After calcitonin immunostaining, the increased numbers of C cells are readily appreciated. More
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FINE-NEEDLE ASPIRATION BIOPSY CHANGES  Left, right: Fine-needle aspiration ...
Published: 01 November 2022
FINE-NEEDLE ASPIRATION BIOPSY CHANGES Figure 3-18 FINE-NEEDLE ASPIRATION BIOPSY CHANGES Left, right: Fine-needle aspiration biopsy changes in a thyroid gland include fibrosis, chronic inflammation, and hemosiderin deposition. These changes may simulate some of the changes seen in the fibrous vari... More
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FIBROUS VARIANT OF HASHIMOTO THYROIDITIS  Left: There is a marked fibrotic ...
Published: 01 November 2022
FIBROUS VARIANT OF HASHIMOTO THYROIDITIS Figure 3-24 FIBROUS VARIANT OF HASHIMOTO THYROIDITIS Left: There is a marked fibrotic reaction, admixed with lymphocytes and plasma cells in the background. Right: The fibrotic reaction compresses and traps some of the Hurthle cells. This may be mistaken ... More
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DYSHORMONOGENETIC GOITER  A: The entire thyroid gland is abnormal. There ar...
Published: 01 November 2022
DYSHORMONOGENETIC GOITER Figure 3-35 DYSHORMONOGENETIC GOITER A: The entire thyroid gland is abnormal. There are varying areas of hyperplasia, often with an exaggerated lobular architecture. B: Some of the nodular areas are distinct and give the low-power impression of independent growth. C: At... More
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RADIATION-INDUCED CHANGES TO THE THYROID GLAND  A: Radiation exposure may d...
Published: 01 November 2022
RADIATION-INDUCED CHANGES TO THE THYROID GLAND Figure 3-11 RADIATION-INDUCED CHANGES TO THE THYROID GLAND A: Radiation exposure may drive the development of multiple separate microfollicular nodules, many of which show varying degrees of nuclear atypia. B: A typical feature of radiation exposure... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-5
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... secretory granules ( 72 ). Chromogranin may not always show significant immunoreactivity in Merkel cell carcinoma, neuroblastoma, small cell lung carcinoma, prolactinoma, or hindgut neuroendocrine tumors ( 72 , 78 ). Staining may vary in intensity among cells: chromogranin A stains parathyroid chief cells...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-2
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... with neuroendocrine differentiation. Some keratins, such as CK14, show differential expression in oxyphil parathyroid adenoma and some chief cells, but may not be expressed in oxyphilic parathyroid carcinomas ( 36 ). Keratins are positive in many other endocrine and neuroendocrine tissues and tumors, including normal...
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TREATED GRAVES DISEASE  The morphologic findings in treated Graves disease ...
Published: 01 November 2022
TREATED GRAVES DISEASE Figure 3-28 TREATED GRAVES DISEASE The morphologic findings in treated Graves disease are highly variable and dependent on both the duration of therapy and the type of treatment. A: In most cases, the follicles maintain their irregular contours, but with less marked colloi... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-3
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... and hyperthyroidism. Tyrosine Kinase Inhibitors Oral tyrosine kinase inhibitors (TKIs) (e.g., lenvatinib, selpercatinib, sunitinib, sorafenib, and imatinib) are commonly used for the treatment of a range of malignancies including gastrointestinal stromal tumors, renal cell carcinoma, hepatocellular carcinoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-4
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... ). Demonstration of steroidogenic enzymes, particularly those unique to the adrenal cortex such as P450c11 (11β-hydroxylase) ( 72 ), may help in the diagnosis of adrenocortical carcinoma. The patterns of expression of these enzymes in adrenocortical carcinoma, however, differ from adrenocortical adenoma, and some...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
DOI: 10.55418/9781933477251-1
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... to this change include: 1) adrenocortical hyperplasias, PitNETs, and carcinomas; 2) ectopic production of ACTH or CRH by tumors such as small cell lung carcinomas, bronchial carcinoids, thymomas, pheochromocytomas, and others; 3) treatment with glucocorticoids for autoimmune diseases, organ transplantation...
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EMBRYONAL <span class="search-highlight">CARCINOMA</span> AND YOLK SAC TUMOR  The embryonal <span class="search-highlight">carcinoma</span> cells (bott...
Published: 01 August 2022
EMBRYONAL CARCINOMA AND YOLK SAC TUMOR Figure 4-93 EMBRYONAL CARCINOMA AND YOLK SAC TUMOR The embryonal carcinoma cells (bottom) show columnar profiles. An adjacent nest of vacuolated yolk sac tumor cells is also seen. More
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EMBRYONAL <span class="search-highlight">CARCINOMA</span>  Embryonal <span class="search-highlight">carcinoma</span> with an appliqué pattern simulates...
Published: 01 August 2022
EMBRYONAL CARCINOMA Figure 4-156 EMBRYONAL CARCINOMA Embryonal carcinoma with an appliqué pattern simulates choriocarcinoma. The smudged cells mimic syncytiotrophoblast, creating a false impression of a biphasic morphology. More
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EMBRYONAL <span class="search-highlight">CARCINOMA</span> AND POSTPUBERTAL-TYPE TERATOMA  Left: Nests and glands ...
Published: 01 August 2022
EMBRYONAL CARCINOMA AND POSTPUBERTAL-TYPE TERATOMA Figure 4-84 EMBRYONAL CARCINOMA AND POSTPUBERTAL-TYPE TERATOMA Left: Nests and glands of embryonal carcinoma are surrounded by primitive mesenchyme. Right: A similar case showing an immunostain for OCT3/4 restricted to the embryonal carcinoma. More
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UROTHELIAL <span class="search-highlight">CARCINOMA</span> OF URINARY BLADDER METASTATIC TO TESTIS  Intratubular ...
Published: 01 August 2022
UROTHELIAL CARCINOMA OF URINARY BLADDER METASTATIC TO TESTIS Figure 10-12 UROTHELIAL CARCINOMA OF URINARY BLADDER METASTATIC TO TESTIS Intratubular growth with comedo-type necrosis resulted in confusion with intratubular embryonal carcinoma, although the nuclei are less pleomorphic and crowded th... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Published: 01 August 2022
DOI: 10.55418/9781933477220-10
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... of testicular metastases (29 percent of cases), but this ranking has a major component of selection bias because of the previously common practice of performing bilateral orchiectomies as a form of hormonal ablation in men with advanced prostatic carcinomas. Approximately 6 percent of therapeutic orchiectomy...