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carcinoma
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Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-09
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... with predominantly acinar differentiation are uncommon. A clinical paraneoplastic syndrome due to massive lipase secretion in some cases of acinar cell carcinoma ( 5 – 7 ) helped draw attention to acinar cell carcinomas before their distinctive histologic features were recognized, and more recent genomic studies...
Images
Published: 01 March 2023
UNDIFFERENTIATED CARCINOMA WITH RHABDOID FEATURES Figure 8-17 UNDIFFERENTIATED CARCINOMA WITH RHABDOID FEATURES A: This carcinoma has rhabdoid features. B,C: Immuno labeling for CK19 is positive (B), while INI1 is lost (C). More
Images
Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-3 ACINAR CELL CARCINOMA A: Acinar cell carcinoma arising in the head of the pancreas with polypoid extension into the duodenum. B: The neoplasm is tan to pink and circumscribed, and shows focal hemorrhage. C: This 15-cm tumor shows a central degenerative cyst. More
Images
Published: 01 March 2023
MIXED ACINAR-DUCTAL CARCINOMA Figure 9-47 MIXED ACINAR-DUCTAL CARCINOMA A: The mucinous acinar cell carcinoma pattern has a solid appearance, with regions closely resembling acinar cell carcinoma, but the periphery of the neoplasm has intracellular mucin. B: There is expression of trypsin (brown... More
Images
Published: 01 March 2023
MIXED ACINAR-DUCTAL CARCINOMA Figure 9-48 MIXED ACINAR-DUCTAL CARCINOMA A: The mucinous acinar cell carcinoma pattern has nests of uniform cells with acinar features surrounded by abundant desmoplastic stroma with focal stromal mucin accumulation. B: The acinar component has granular apical cyto... More
Images
Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-5 ACINAR CELL CARCINOMA Top: At low power, acinar cell carcinomas are circumscribed and surrounded by a fibrous pseudocapsule into which mushroom-like projections may grow. Bottom: Rarely, there is polypoid growth into the pancreatic ducts; non-neoplastic ductal ep... More
Images
Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-29 ACINAR CELL CARCINOMA Acinar cell carcinomas can lack nucleoli and show anisonucleosis and rare signet ring-like cells (Papanicolaou stain). More
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-08
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
...Variants of adenocarcinoma are important to recognize because they can harbor unique genetic drivers, carry a significantly better or worse prognosis than conventional ductal adenocarcinoma, and have specific therapeutic sensitivities. For example, medullary carcinomas of the pancreas...
Images
Published: 01 March 2023
MIXED ACINAR-NEUROENDOCRINE CARCINOMA Figure 9-45 MIXED ACINAR-NEUROENDOCRINE CARCINOMA Smears of mixed acinar neuroendocrine carcinomas are highly cellular, similar to pure acinar cell carcinomas. Atypical plasmacytoid cells with granular cytoplasm appear singly dispersed (Diff Quik). More
Images
Published: 01 March 2023
METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Figure 14-2 METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Histology of a nodular metastasis of renal cell carcinoma (left). Nests of clear cell carcinoma extend adjacent to non-neoplastic islet cells (right). More
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Published: 01 March 2023
ACINAR CELL CARCINOMA Figure 9-31 ACINAR CELL CARCINOMA Immunolabeling for trypsin in a smear of acinar cell carcinoma. More
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Published: 01 March 2023
COLLOID CARCINOMA Figure 8-9 COLLOID CARCINOMA An intestinal-type intraductal papillary mucinous neoplasm (center and top) has an associated invasive colloid carcinoma (bottom). More
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Published: 01 March 2023
MIXED ACINAR-NEUROENDOCRINE CARCINOMA Figure 9-38 MIXED ACINAR-NEUROENDOCRINE CARCINOMA The neoplasm is solid and fleshy, with minimal fibrous stroma, similar to acinar cell carcinomas. More
Images
Published: 01 March 2023
INTRADUCTAL TUBULOPAPILLARY NEOPLASM WITH ASSOCIATED INVASIVE CARCINOMA Figure 6-59 INTRADUCTAL TUBULOPAPILLARY NEOPLASM WITH ASSOCIATED INVASIVE CARCINOMA Left: Irregular and angulated glands infiltrate the periductal stroma, with associated stromal reaction (inset). Right: Subtle nests and str... More
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Published: 01 March 2023
COLLOID CARCINOMA Figure 8-6 COLLOID CARCINOMA Left: On cross section, large gelatinous areas are embedded in the stroma (lower half). An area of cystic degeneration is present (top). Right: Gelatinous colloid carcinoma in the head of the pancreas. An associated intraductal papillary mucinous ne... More
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-02
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
.... Von Hippel-Lindau (VHL)-associated serous cystic neoplasm v. Mixed serous neuroendocrine neoplasm b. Serous cystadenocarcinoma c. Carcinoma ex serous cystadenoma 2. Mucinous cystic neoplasms a. Mucinous cystic neoplasm b. Mucinous cystic neoplasm with an associated...
Book Chapter
Book: Tumors of the Pancreas
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
DOI:
10.55418/9781933477275-14
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... implications. Most metastases to the pancreas are not treated surgically, although pancreatic resection is performed for isolated metastases from a select group of neoplasms including metastatic clear cell renal cell carcinoma, melanoma, and colorectal carcinoma ( 1 – 7 ). Metastases to the pancreas are less...
Images
Published: 01 March 2023
METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Figure 14-4 METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE Air-dried Romanowsky-stained smears enhance the appearance of microvesicles in the abundant cytoplasm of renal cell carcinoma (left), juxtaposed with comparatively small non-neoplastic ac... More
Images
Published: 01 March 2023
PANCREATIC NEUROENDOCRINE CARCINOMA, LARGE CELL TYPE Figure 12-86 PANCREATIC NEUROENDOCRINE CARCINOMA, LARGE CELL TYPE Left: KRAS and TP53 mutations were present in this high-grade neuroendocrine carcinoma with large, atypical nuclei and moderately abundant cytoplasm. Right: Large cells with irregular nuclei and coarse chromatin (left: H&E stain; right: Papanicolaou stain). More
Images
Published: 01 March 2023
METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE, INVOLVING WELL-DIFFERENTIATED NEUROENDOCRINE TUMOR Figure 14-6 METASTATIC RENAL CELL CARCINOMA, CLEAR CELL TYPE, INVOLVING WELL-DIFFERENTIATED NEUROENDOCRINE TUMOR The renal cell carcinoma (top) has clear cell features whereas the neuroendocrine t... More