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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-23
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... parameter by which patients with localized melanoma are staged according to the 8th edition of the American Joint Committee on Cancer (AJCC) Melanoma Staging System ( Table 23-1 ) ( 3 ). Tumor thickness should be measured in millimeters. The numerical value does not need to be recorded beyond the level...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-20
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... for pediatric melanoma include large or giant congenital melanocytic nevi, an atypical nevus phenotype, freckles, history of sunburns, neurocutaneous melanosis, and a prior history of cancer, xeroderma pigmentosum, or immunosuppression ( 4 – 8 ). Excessive exposure to ultraviolet light, from indoor/artificial...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-14
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... . BMC Cancer   2016 ; 16 : 691 . 6. Chen   YA , Teer   JK , Eroglu   Z , et al . Translational pathology, genomics and the development of systemic therapies for acral melanoma . Semin Cancer Biol   2020 ; 61 : 149 - 57 . 7. Bradford   PT , Goldstein   AM , Master   ML...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-22
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... and the value of molecular testing as surrogate diagnostic marker . Am J Surg Pathol   2016 ; 40 : 181 - 91 . 18. Wagner   E . [ Case of a combination of a pigment cancer with a pure pigment tumor .] Arch Heilkunde   1864 ; 5 : 280 - 4 . [ German ] 19. Gershenwald   JE , Scolyer   RA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... behavior of primary human malignant melanomas of the skin . Cancer Res   1969 ; 29 : 705 - 27 . 2. LeBoit   PE , Burg   G , Weedon   D , Sarasin   A . Pathology and genetics of skin tumours , 3rd ed. Lyon : IARC ; 2005 ; 68 - 9 . 3. Cochran   AJ , Bastian   BC , Elder...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-04
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... to arise on intermittently sun-exposed skin. The most common site is the back. With regard to the clinical characteristics of individual lesions, there are a number of criteria that have been proposed by the International Agency for Research on Cancer ( 7 , 8 ). Somewhere in the lesion there should...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-10
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... cancers presenting in men show many similarities to those occurring in women, with the notable exception of more frequent presentation at high stage. Breast cancer represents less than 1 percent of cancers occurring in men. Clinical Features. While breast cancer is rare in men, there are several risk...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... , Helwig   EB , Graham   JH . Balloon cell malignant melanoma of the skin. A clinicopathologic study of 34 cases with histochemical, immunohistochemical, and ultrastructural observations . Cancer   1992 ; 69 : 2942 - 52 . 2. Magro   CM , Abraham   RM , Guo   R , et al . Deep...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-08
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... into the special histologic types. Cancers that do not demonstrate the specific morphologic characteristics diagnostic of these other histologic types are classified as invasive breast carcinomas of no special type (NST). This chapter will begin with an overview of the epidemiology, prognostic criteria, biomarker...
Book
Book Cover Image
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...This chapter addresses the histopathologic changes associated with persistent melanocytic nevi presenting with repigmentation after prior surgery and nevi changing in response to nonsurgical mechanical trauma or biochemical injury, such as effects from cancer treatment. Knowledge of the effects...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-16
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... (a rare variant of spindle cell melanoma) . Cancer   1971 ; 28 : 914 - 36 . 2. Busam   KJ . Desmoplastic melanoma . Clin Lab Med   2011 ; 31 : 321 - 30 . 3. Busam   KJ . Desmoplastic melanoma . In: Busam   KJ , Gerami   P , Scolyer   RA , eds. Pathology of melanocytic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... behavior of primary human malignant melanomas of the skin . Cancer Res   1969 ; 29 : 705 - 27 . 2. Duncan   LM , Bastian   BC , Elder   DE , Mihm   MC   Jr . Low-CSD melanoma (superficial spreading melanoma) . In: Elder   E , Massi   D , Scolyer   RA , Willemze   R , eds...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-01
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... is also expressed in normal breast tissue, but as mentioned above, it has no use in clinical practice at this time ( 34 ). Interestingly, studies have demonstrated that levels of ERβ and/or the ratio of ERβ to ERα may be important in determining the risk of breast cancer development, with higher levels...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...: a clinicopathological analysis of the criteria for diagnosis and prognosis . Cancer   1953 ; 6 : 1 - 45 . 3. McWorther   HE , Woolner   LB . Pigmented nevi, juvenile melanomas and malignant melanomas in children . Cancer   1954 ; 7 : 564 - 85 . 4. Connors   RC , Chalet   MD , Ackerman   AB...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-15
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... of breast cancer biomarker studies. It is also essential to be aware of the clinical and imaging findings, as well as the results of any prior biopsies, or prior history of breast cancer and associated treatment, so as to guide tissue sampling. This chapter covers the handling and processing...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., the presence of multiple lesions is likely associated with a tumor predisposition syndrome ( 6 – 8 , 11 ), warranting a careful inquiry into a family history of BAP1-associated cancers (such as cutaneous and uveal melanoma, mesothelioma, renal cell carcinoma, other skin cancers) and possible germline...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... on Cancer (AJCC) staging parameters, most primary tumors are pT4a. As with other melanomas, tumor thickness is relevant for the prognosis. However, we caution against applying prognostic models derived from conventional melanoma originating in the epidermis to blue melanomas. There is a range...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-08
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... : 212 - 29 . [German] 19. Montgomery   H , Kahler   JE . The blue nevus (Jadassohn-Tieche): its distinction from ordinary moles and malignant melanomas . Am J Cancer   1939 ; 36 : 527 - 39 . 20. Allen   AC . A reorientation on the histogenesis and clinical significance...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-04
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... is required. Evaluation of the proximity of classic LCIS to the margins is not indicated. Chemoprevention with selective estrogen receptor (ER) modulators (SERMs) or an aromatase inhibitor (AI) may be offered to reduce the subsequent breast cancer risk. The reduction in risk is substantial (about 50 percent...