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borderline
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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... Score value >8.5 Altered reticulin staining + at least one of mitotic index, presence of necrosis, and/or vascular invasion Malignant if one or more major criteria; of uncertain malignant potential (borderline) if one or more minor criteria only Main advantages The most widely adopted...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... including pheochromocytoma ( 111 ) and adrenal cortical adenoma ( 112 ) have occasionally been reported. Secondary Adrenal Cortical Insufficiency (Addison Disease) Caused by Adrenal Metastases Acute adrenal insufficiency can result from the stress of illness superimposed on smoldering borderline...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
..., including multiple, bilateral bead-like small nodules ( 33 , 37 ). Functional imaging studies using iodine-131-6-β-iodomethyl-19-norcholesterol (NP-59) scintigraphy/PET scans help to identify the bilateral nature of the disease in ACTH-independent Cushing disease with borderline or normal CT scans ( 38...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-07
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., measuring 1 to 2 mm3 each ( 1 ). If there are less than two fragments with less than 50 percent interpretable myocardium, the specimen is considered inadequate and anything in between is considered a borderline specimen. Most biopsies obtained for suspected myocarditis are submitted for histology...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-15
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... thigh, groin, and perineum. The Ridley-Jopling classification divides leprosy into two main (or polar) categories: tuberculoid and lepromatous, with three borderline categories that bridge the disease spectrum. The most common clinical presentations are borderline or hybrid...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-03
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... or borderline low CD4-positive T-cell counts ( 73 ). Thus, PML needs to be a clinical and pathological diagnostic consideration even in individuals who are HIV negative, especially in those with other types of cell-mediated immune deficiency. Although JC virus is found in kidney, lymphoid and bone marrow...
Images
Published: 01 January 2024
BORDERLINE PHYLLODES TUMOR Figure 5-28 BORDERLINE PHYLLODES TUMOR A. Low power demonstrates a fibroepithelial lesion with moderate stromal cellularity and irregular distribution of the glands. B,C: At intermediate (B) and high (C) power, the stromal cells show moderate cytologic atypia; scattere... More about this image found in BORDERLINE PHYLLODES TUMOR A. Low power demonstrates a fibroepithelial les...
Images
Published: 01 January 2024
BORDERLINE PHYLLODES TUMOR Figure 5-29 BORDERLINE PHYLLODES TUMOR The tumor border is irregular (“scalloped”) in this area, with subtle infiltration of the adjacent adipose tissue. More about this image found in BORDERLINE PHYLLODES TUMOR The tumor border is irregular (“scalloped”) in ...
Images
Published: 01 January 2024
MALIGNANT PHYLLODES TUMOR Figure 5-34 MALIGNANT PHYLLODES TUMOR A: Low power demonstrates an admixture of benign epithelial elements, malignant spindle cells, and adipocytes. B,C: At intermediate (B) and high (C) power, the marked cytologic atypia of the stromal cells is apparent; lipoblasts are... More about this image found in MALIGNANT PHYLLODES TUMOR A: Low power demonstrates an admixture of benign...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-09
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... or “borderline” DPN-like melanocytic neoplasm of uncertain malignant potential ( 12 ). TREATMENT AND PROGNOSIS DPN is a benign melanocytic neoplasm. Local recurrences of histopathologically incompletely removed lesions are rare ( 7 ). The risk for progression to melanoma is unknown, but likely a rare event...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-05
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
...Fibroadenoma and phyllodes tumor comprise the fibroepithelial lesions of the breast, which span the spectrum of benign through borderline to malignant tumors. Fibroadenomas are common, and for the most part easily diagnosed; phyllodes tumors are much less frequently encountered and present some...
Images
Published: 15 November 2023
BORDERLINE LYMPHOCYTIC MYOCARDITIS Figure 22-8 BORDERLINE LYMPHOCYTIC MYOCARDITIS Borderline myocarditis consists of an inflammatory infiltrate without associated myocyte injury. This finding should prompt careful evaluation for active myocarditis elsewhere. More about this image found in BORDERLINE LYMPHOCYTIC MYOCARDITIS Borderline myocarditis consists of an i...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-06
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... the correct diagnosis of a persistent nevus include a consistent clinical history, rapid recurrence, and a trizonal histologic pattern. Whenever possible, especially when in doubt, a review of the preceding lesion should be attempted. For borderline lesions, a recommendation for complete excision is generally...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... with atypical or borderline histologic features. DIFFERENTIAL DIAGNOSIS A combined melanocytic nevus may be confused with a melanoma associated with a nevus. Combined conventional and blue nevi are usually readily recognized as benign. More challenging is the diagnosis of combined nevi with a spitzoid deep...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of malignancy. Blue Melanoma versus Miscellaneous Pigment-Synthesizing Tumors. Blue nevus-like melanoma may also be confused with a range of pigmented benign, “borderline,” or malignant melanocytic neoplasms, such as proliferative nodules, PEM, or miscellaneous tumors in the spectrum of “pigment-synthesizing...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... penetrating nevus-like borderline tumors: a unique subset of ambiguous melanocytic tumors with malignant potential and normal cytogenetics . Eur J Dermatol 2014 ; 24 : 594 - 602 . 3. Hantschke M , Mentzel T , Kutzner H . Follicular malignant melanoma: a variant of melanoma...
Images
Published: 15 November 2023
PLEXOGENIC PULMONARY HYPERTENSION: GRADE 3 (BORDERLINE REVERSIBILITY) Figure 34-28 PLEXOGENIC PULMONARY HYPERTENSION: GRADE 3 (BORDERLINE REVERSIBILITY) Left, right: Concentric laminar intimal fibrosis (or fibroelastosis) and adventitial fibrosis. (Right: Verhoeff-van Gieson stain). More about this image found in PLEXOGENIC PULMONARY HYPERTENSION: GRADE 3 (BORDERLINE REVERSIBILITY) Left...
Images
Published: 15 November 2023
PLEXOGENIC PULMONARY HYPERTENSION: GRADE 5 (BORDERLINE REVERSIBILITY) Figure 34-29 PLEXOGENIC PULMONARY HYPERTENSION: GRADE 5 (BORDERLINE REVERSIBILITY) The dilatation lesion is tortuous, without apparent medial destruction. More about this image found in PLEXOGENIC PULMONARY HYPERTENSION: GRADE 5 (BORDERLINE REVERSIBILITY) The ...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-03
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... of an excision specimen where definitive categorization based upon examination of the entire lesion can occur. In borderline cases, it is prudent to be descriptive, rendering a diagnosis such as “atypical intraductal proliferation bordering on low nuclear grade DCIS” or “severely atypical ductal hyperplasia...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch34
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... a Grade Lesions in Muscular Pulmonary Arteries Reversible 1A Muscular extension into arterioles Yes 1B Medial hypertrophy Yes 1C Loss of intra-acinar arteries Yes b 2 Concentric intimal proliferation Yes 3 Concentric laminar intimal fibrosis Borderline c...
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