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PRIMARY PLEURAL SARCOMA  A,B: A primary malignant peripheral nerve sheath t...
Published: 01 June 2022
PRIMARY PLEURAL SARCOMA Figure 5-19 PRIMARY PLEURAL SARCOMA A,B: A primary malignant peripheral nerve sheath tumor presents as a nodular mass between two ribs. C: A primary chondrosarcoma arises from a rib and extends to involve the pleural space. If no origin from bone is seen in tumors contain... More
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SARCOMATOID MESOTHELIOMA WITH HETEROLOGOUS ELEMENTS  A: A focus of osteosar...
Published: 01 June 2022
SARCOMATOID MESOTHELIOMA WITH HETEROLOGOUS ELEMENTS Figure 3-61 SARCOMATOID MESOTHELIOMA WITH HETEROLOGOUS ELEMENTS A: A focus of osteosarcoma-like tumor is present. B: There is a focus of osteoid-like matrix. C: More mature bone formation is present. More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Publisher: American Registry of Pathology
Published: 01 June 2022
DOI: 10.55418/9781933477190-5
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
... tumor presents as a nodular mass between two ribs. C: A primary chondrosarcoma arises from a rib and extends to involve the pleural space. If no origin from bone is seen in tumors containing bone or chondroid stroma, and especially if diffuse disease, then a mesothelioma with chondrosarcomatous...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Publisher: American Registry of Pathology
Published: 01 June 2022
DOI: 10.55418/9781933477190-7
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
... of epithelioid hemangioendothelioma . Arch Pathol Lab Med   1987 ; 111 : 459 - 63 . 11. Nicholson   AG , Anderson   E , Saha   S , Indrajith   M , Conry   B , Hughes   J . Progressive dyspnoea, pleural effusions and lytic bone lesions . Thorax   2008 ; 63 : 492, 554 . 12...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Publisher: American Registry of Pathology
Published: 01 June 2022
DOI: 10.55418/9781933477190-6
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
...   M , Conry   B , Hughes   J . Progressive dyspnoea, pleural effusions and lytic bone lesions . Thorax   2008 ; 63 : 492, 554 . 77. Diamond   EL , Dagna   L , Hyman   DM , et al . Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Publisher: American Registry of Pathology
Published: 01 June 2022
DOI: 10.55418/9781933477190-3
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
... numerous lymphocytes, raising the differential diagnosis of lymphoma. SARCOMATOID MESOTHELIOMA WITH HETEROLOGOUS ELEMENTS Figure 3-61 SARCOMATOID MESOTHELIOMA WITH HETEROLOGOUS ELEMENTS A: A focus of osteosarcoma-like tumor is present. B: There is a focus of osteoid-like matrix. C: More mature bone...
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VENO-OCCLUSIVE DISEASE (SINUSOIDAL OBSTRUCTIVE SYNDROME)  There is marked z...
Published: 01 January 2022
VENO-OCCLUSIVE DISEASE (SINUSOIDAL OBSTRUCTIVE SYNDROME) Figure 1-78 VENO-OCCLUSIVE DISEASE (SINUSOIDAL OBSTRUCTIVE SYNDROME) There is marked zone 3 congestion and thrombosis of the central veins. The patient was status post-bone marrow transplant. More
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SINUSOIDAL CONGESTION: SYSTEMIC AUTOIMMUNE DISEASE  This biopsy was origina...
Published: 01 January 2022
SINUSOIDAL CONGESTION: SYSTEMIC AUTOIMMUNE DISEASE Figure 1-80 SINUSOIDAL CONGESTION: SYSTEMIC AUTOIMMUNE DISEASE This biopsy was originally signed out as suggesting vascular outflow disease. When work-up revealed no evidence of vascular outflow disease, the case was sent for consultation. This p... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Publisher: American Registry of Pathology
Published: 01 October 2021
DOI: 10.55418/9781933477138-01
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
...Table 1-1 CATEGORIES OF PRIMARY NEOPLASMS OF BONE BASED ON PHENOTYPE Neoplasms of osteoblastic phenotype: bone-forming tumors Neoplasms of chondrocytic phenotype: cartilage-forming tumors Neoplasms of fibroblastic phenotype: fibrous and fibrohistiocytic tumors Neoplasms...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Publisher: American Registry of Pathology
Published: 01 October 2021
DOI: 10.55418/9781933477138-02
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
...Table 2-1 MOLECULAR MECHANISMS IN BONE TUMORS Mechanism Examples Simple karyotypes  Deregulated transcription:   Translocations resulting in chimeric transcription factors Ewing sarcoma   Mutations causing epigenetic changes Enchondroma (IDH) Giant...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Publisher: American Registry of Pathology
Published: 01 October 2021
DOI: 10.55418/9781933477138-03
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... of the upper extremities (arrows) without evidence of restricted diffusion to suggest malignant degeneration. BONE SCINTIGRAPHY Figure 3-5 BONE SCINTIGRAPHY Anterior (left) and posterior (right) images from a technetium (Tc)-99m-labeled diphosphonate scintigraphy (bone scan) in a patient with osteosarcoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Publisher: American Registry of Pathology
Published: 01 October 2021
DOI: 10.55418/9781933477138-04
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
...BONE ISLAND Figure 4-3 BONE ISLAND A: Frontal radiograph of the femur shows a large irregular bone island in the diaphysis. B: Magnified radiograph shows the star-like contour with spiculated margins and variable density of the mass. C: Axial T1-weighted magnetic resonance imaging (MRI...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Publisher: American Registry of Pathology
Published: 01 October 2021
DOI: 10.55418/9781933477138-05
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
...CONVENTIONAL OSTEOSARCOMA Figure 5-2 CONVENTIONAL OSTEOSARCOMA A: Frontal radiograph of the distal femur shows a blastic and lytic, poorly demarcated tumor originating in the metadiaphyseal portion of the femur, transgressing the cortex, displacing the periosteum, producing reactive bone (Codman...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Publisher: American Registry of Pathology
Published: 01 October 2021
DOI: 10.55418/9781933477138-08
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
... by reactive dense bone. B: In another case, a coronal reformatted CT of the proximal tibia shows a resolving tumor being replaced by newly formed bone. C: Corresponding coronal T1-weighted MRI shows heterogeneous signal intensity with low signal regions and cortical thickening. NONOSSIFYING FIBROMA Figure 8...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Publisher: American Registry of Pathology
Published: 01 October 2021
DOI: 10.55418/9781933477138-13
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
...GIANT CELL TUMOR OF BONE Figure 13-1 GIANT CELL TUMOR OF BONE A,B: Frontal (A) and lateral (B) radiographs of the right hip show a lytic lesion with a narrow zone of transition in the femoral epiphysis (arrows). C: Corresponding axial computerized tomography (CT) image shows a lytic lesion...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Publisher: American Registry of Pathology
Published: 01 October 2021
DOI: 10.55418/9781933477138-14
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
..., Kattapuram SV, Rosenthal DI. Diagnostic pathology: bone, 2nd ed. Philadelphia: Elsevier, 2017.) INTRAOSSEOUS GANGLION CYST OF THE TIBIAL PLAFOND Figures 14-2 INTRAOSSEOUS GANGLION CYST OF THE TIBIAL PLAFOND A: Frontal radiograph shows a well-defined lytic lesion of the tibial plafond. B,C: Coronal T1...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Publisher: American Registry of Pathology
Published: 01 October 2021
DOI: 10.55418/9781933477138-16
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
...Table 16-1 HISTIOCYTIC NEOPLASMS OF BONE Neoplasm Patients Skeletal Involvement Morphology Immunophenotype Genetic Features Prognosis Langerhans cell histiocytosis (LCH) Children more often affected than adults, males > females Single or multiple lesions in skull (most common...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Publisher: American Registry of Pathology
Published: 01 October 2021
DOI: 10.55418/9781933477138-18
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
...Table 18-1 IMMUNOHISTOCHEMICAL MARKERS FOR METASTATIC CARCINOMAS TO BONE: PRIMARY SITE DETERMINATION a Marker Subcellular Localization Primary Sites Comments ARG1 Cytoplasmic/nuclear Liver Cadherin-17 Membranous Colon/rectum, upper GI b , pancreas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Publisher: American Registry of Pathology
Published: 01 January 2022
DOI: 10.55418/9781933477183-10
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... Disorder OMIM Gene/Locus #/Phenotype # Gene Gene Product Affected Organs Liver Histology Gaucher disease 606463/230800 GBA Acid beta-glucosidase Multiple organs; liver, bone marrow, spleen; CNS in types II and III Lipid-laden histiocytes with characteristic finely striated cytoplasm...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Publisher: American Registry of Pathology
Published: 01 January 2022
DOI: 10.55418/9781933477183-12
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... , Malard   F , Abecassis   M , et al . Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives—a position statement from the European Society for Blood and Marrow Transplantation (EBMT) . Bone Marrow Transplant   2015 ; 50 : 781 – 9 . 33. McDonald   GB...