PARAGANGLIOMA METASTATIC TO VERTEBRAL BONE Figure 9-41 PARAGANGLIOMA METASTATIC TO VERTEBRAL BONE Residual bone is present at bottom center. Since normal paraganglia do not occur in bone, the diagnosis of metastasis is unequivocal. More about this image found in PARAGANGLIOMA METASTATIC TO VERTEBRAL BONE Residual bone is present at bot...

NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW Figure 11-37 NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW This trephine biopsy shows extensive involvement by NB, which is even appreciated without immunohistochemistry. More about this image found in NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW This trephine biopsy show...

SITES OF METASTASIS FROM ADRENAL CORTICAL CARCINOMA Figure 6-39 SITES OF METASTASIS FROM ADRENAL CORTICAL CARCINOMA Lung (A), bone (B), brain (C), and skin (a surgically excised nodule on the scalp, D) metastases from ACC. More about this image found in SITES OF METASTASIS FROM ADRENAL CORTICAL CARCINOMA Lung (A), bone (B), br...

BONE MARROW METASTASIS OF NEUROBLASTOMA Figure 11-38 BONE MARROW METASTASIS OF NEUROBLASTOMA A: Chromogranin A highlights the presence of isolated fields of tumor cells in paucicellular bone marrow following chemotherapy. B: Synaptophysin highlights the presence of isolated fields of tumor cells... More about this image found in BONE MARROW METASTASIS OF NEUROBLASTOMA A: Chromogranin A highlights the p...

PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE Figure 4-18 PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE Myelolipomatous metaplasia with bone formation. More about this image found in PRIMARY BILATERAL MACRONODULAR ADRENOCORTICAL DISEASE Myelolipomatous meta...

ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-30 ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME An area shows metaplastic bone formation in association with a fibrotic stroma. More about this image found in ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME An area shows me...

METASTATIC PHEOCHROMOCYTOMA Figure 8-52 METASTATIC PHEOCHROMOCYTOMA The presence of paraganglioma in lymph node (A) or bone (B) is unequivocal evidence of metastatic spread, since these tissues do not harbor paraganglia and therefore the disease cannot represent multifocal primary lesions in a ge... More about this image found in METASTATIC PHEOCHROMOCYTOMA The presence of paraganglioma in lymph node (A...

DISTRIBUTION OF NEUROBLASTOMA BY SEX AND STAGE OVER AGE Figure 11-1 DISTRIBUTION OF NEUROBLASTOMA BY SEX AND STAGE OVER AGE Nearly 90 percent of patients are below 5 years of age at diagnosis. The left side of each pair of columns represents male patients and the right side of each pair of column... More about this image found in DISTRIBUTION OF NEUROBLASTOMA BY SEX AND STAGE OVER AGE Nearly 90 percent ...

METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA Figure 11-5 METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA A 2-year old girl presented with fever and a painless swelling in the abdomen. Blood and urine cultures were negative and initial ultrasound was suspicious of a renal tumor. After referral to an expert center, clinical examination (slight hypertension), laboratory testing (increased urinary catecholamines), and abdominal MRI imaging showed that a diagnosis of metastatic NB was more likely. The MRI depicted a right-sided adrenal mass with retroperitoneal lymph node metastases. Additional MIBG scintigraphy shows increased uptake in the primary adrenal NB and locoregional lymph nodes (black arrow), but also extensive bone marrow metastases throughout. At the top, is a classic orbital metastasis and at the bottom, a tibial metastasis (red arrows). Histopathology showed an undifferentiated NB, with MYCN amplification, indicative of a high-risk NB patient. (Courtesy of Dr. A. J. Braat, University Medical Center Utrecht, The Netherlands) More about this image found in METAIODOBENZYLGUANIDINE (MIBG) SCAN OF WIDELY METASTASIZED NEUROBLASTOMA A...

USE OF SPECIAL STAINS IN THE DIAGNOSIS OF INFECTIOUS DISEASES Figure 1-2 USE OF SPECIAL STAINS IN THE DIAGNOSIS OF INFECTIOUS DISEASES A,B: Bone marrow H&E (A) and Grocott methenamine silver (B) stains. The latter shows numerous budding Histoplasma capsulatum yeasts. C–E: H&E stain (C,D) on a pituitary gland specimen showing histologic findings suspicious for tissue pathogens. A strongly positive von Kossa calcium stain (E), however, confirms the suspicious deposits as calcifications and excludes infectious microorganisms. More about this image found in USE OF SPECIAL STAINS IN THE DIAGNOSIS OF INFECTIOUS DISEASES A,B: Bone ma...

PARVOVIRUS B19 Figure 8-3 PARVOVIRUS B19 Bone marrow histology shows a hypercellular appearance, with intranuclear parvovirus B19 inclusions affecting erythroid precursors (A, center and B, bottom). More about this image found in PARVOVIRUS B19 Bone marrow histology shows a hypercellular appearance, wit...