MERKEL CELL CARCINOMA Figure 9-50 MERKEL CELL CARCINOMA A: At low power, the small round blue cell tumor is centered on the dermis. B: Higher power shows sheets of cells with a high nuclear to cytoplasmic ratio, prominent apoptosis, and brisk mitotic activity. C: Classic paranuclear “dot-like” ... More about this image found in MERKEL CELL CARCINOMA A: At low power, the small round blue cell tumor is ...

H. HEILMANNII INFECTION Figure 13-34 H. HEILMANNII INFECTION A: A methylene blue stain demonstrates two long spiraled H. heilmannii organisms (arrow) adjacent the gastric mucosa. B: H. heilmannii bacilli stain with an H. pylori immunoperoxidase stain. The organisms’ characteristic spirochetal morphology is demonstrated on this high-power view. (Courtesy of Dr. B. Kovái, University of Szeged, Szeged, Hungary) More about this image found in H. HEILMANNII INFECTION A: A methylene blue stain demonst...

BORRELIA SPP PATHOGENESIS Figure 15-6 BORRELIA SPP PATHOGENESIS Blue arrows show vector and bacterial factors while red arrows show host factors. More about this image found in BORRELIA SPP PATHOGENESIS Blue arrows show vector and bac...

TYPICAL FACIAL SKIN LESION IN PINTA Figure 15-34 TYPICAL FACIAL SKIN LESION IN PINTA There is “slate blue” discoloration. (Courtesy of the CDC PHIL) More about this image found in TYPICAL FACIAL SKIN LESION IN PINTA There is “slate blue” discoloration. (...

PROTOTHECA SPP Figure 19-9 PROTOTHECA SPP Culture (A), lactophenol cotton blue preparation (B), and histopathologic morphology using GMS (C) and Gridley (D) stains. (Courtesy of the CDC PHIL) More about this image found in PROTOTHECA SPP Culture (A), lactophenol cotton blue prepa...

FUSARIUM SPP Figure 21-35 FUSARIUM SPP Culture (A) and lactophenol cotton blue preparation (B). (Courtesy of the CDC PHIL) More about this image found in FUSARIUM SPP Culture (A) and lactophenol cotton blue prep...

ESOPHAGEAL CANDIDIASIS Figure 22-5 ESOPHAGEAL CANDIDIASIS Alcian blue/PAS-d stain of a pseudomembrane demonstrates an abundance of fungal yeasts and filamentous forms in a background of necrotic debris, bacterial organisms, and isolated degenerated squames. More about this image found in ESOPHAGEAL CANDIDIASIS Alcian blue/PAS-d stain of a pseudomembrane demonst...

DEMATIACEOUS FUNGAL CONIDIA Figure 24-29 DEMATIACEOUS FUNGAL CONIDIA Characteristic conidia are seen with a lactophenol cotton blue preparation. (Courtesy of the CDC PHIL) More about this image found in DEMATIACEOUS FUNGAL CONIDIA Characteristic conidia are seen with a lactoph...

HIV LEUKOENCEPHALOPATHY Figure 9-8 HIV LEUKOENCEPHALOPATHY Cortical white matter with myelin loss is demonstrated by reduced staining using the luxol fast blue technique. More about this image found in HIV LEUKOENCEPHALOPATHY Cortical white matter with myelin loss is demonstr...

CRYPTOCOCCAL INFLAMMATORY PSEUDOTUMOR Figure 20-7 CRYPTOCOCCAL INFLAMMATORY PSEUDOTUMOR There is a vaguely storiform proliferation of plump myofibroblasts and histiocytes (A) with intervening yeasts highlighted with an Alcian blue stain (B). More about this image found in CRYPTOCOCCAL INFLAMMATORY PSEUDOTUMOR There is a vaguely storiform prolife...

HISTOPLASMA CAPSULATUM Figure 23-9 HISTOPLASMA CAPSULATUM On culture, the characteristic fluffy colonies (A) and mycelium with tuberculate macroconidia (B, lactophenol cotton blue) are seen. (Courtesy of the CDC PHIL) More about this image found in HISTOPLASMA CAPSULATUM On culture, the characteristic flu...

PATHOGENESIS OF TUBERCULOSIS Figure 12-46 PATHOGENESIS OF TUBERCULOSIS Red arrows represent inhibitory host activity towards mycobacterial growth while blue arrows represent mycobacterial factors that lead to latency or growth. More about this image found in PATHOGENESIS OF TUBERCULOSIS Red arrows represent inhibitory host activity...

CRYPTOCOCCUS SPP Figure 20-6 CRYPTOCOCCUS SPP Grocott-Gomori methenamine silver (A), alcian-blue/PAS-d (B), and Fontana-Masson (C) stains. Note the organism’s positivity (for melanin) on the latter stain. More about this image found in CRYPTOCOCCUS SPP Grocott-Gomori methenamine silver (A), a...

LEPROMATOUS LEPROSY Figure 15-22 LEPROMATOUS LEPROSY High-power view shows a dermal infiltrate of foamy macrophages containing intracellular blue-gray material, corresponding to abundant mycobacteria (so-called Virchow cells). More about this image found in LEPROMATOUS LEPROSY High-power view shows a dermal infiltrate of foamy mac...

H. PYLORI INFECTION Figure 13-33 H. PYLORI INFECTION Coccoid forms of H. pylori may sometimes be identified in stomach biopsy material (A, arrow; methylene blue stain) and are positive with H. pylori immunohistochemistry (B). More about this image found in H. PYLORI INFECTION Coccoid forms of H. pylori...

TALAROMYCES MARNEFFEI Figure 19-7 TALAROMYCES MARNEFFEI Culture (A), morphology by lactophenol cotton blue stain (C), and histopathologic characteristics with GMS (B) and Gridley (D) stains. (Courtesy of the Centers for Disease Control and Prevention [CDC] Public Health Image Library [PHIL]) More about this image found in TALAROMYCES MARNEFFEI Culture (A), morphology by lactophe...

WHIPPLE DISEASE Figure 13-39 WHIPPLE DISEASE There is strong diastase-resistant PAS positivity in the macrophage infiltrate (A; alcian blue/PAS-d stain). Specific T. whipplei immunohistochemical testing is also available (B,C). (Courtesy of Dr. E. Montgomery, University of Miami, Miami, FL) More about this image found in WHIPPLE DISEASE There is strong diastase-resistant PAS positivity in the m...

G. DUODENALIS ORGANISMS Figure 26-20 G. DUODENALIS ORGANISMS G. duodenalis organisms may occasionally be identified in the stomach (arrow), usually in the setting of achlorhydria, and may be mistaken for mucin droplets by the unwary (A: H&E, B: methylene blue stain. Courtesy of Dr. H. Venbrux, Camp Hill, PA) More about this image found in G. DUODENALIS ORGANISMS G. duodenalis or...

LATE STAGE OF SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE) Figure 3-22 LATE STAGE OF SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE) Whole mount section of autopsy brain shows marked atrophy, secondary ventricular enlargement (hydrocephalus ex vacuo), and mild meningeal fibrosis. Note the gaping space b... More about this image found in LATE STAGE OF SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE) Whole mount secti...

HISTOLOGIC DETECTION OF H. PYLORI Figure 13-32 HISTOLOGIC DETECTION OF H. PYLORI A: Many basophilic H. pylori bacilli are easily identified on a routine hematoxylin and eosin (H&E) stain in the mucin adjacent to this gastric biopsy. B: A methylene blue stain is an example of a monochromatic stain, which can be used to highlight the organisms. C: A silver-based Warthin-Starry stain shows numerous small curved H. pylori bacilli, clearly visible against a counterstained background. D: An H. pylori immunoperoxidase stain confirms abundant organisms adjacent to the superficial gastric epithelium. More about this image found in HISTOLOGIC DETECTION OF H. PYLORI A: Many basophilic