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Images
Figure 2-30
Published: 01 June 2025
COMBINED NEUROENDOCRINE CARCINOMA Figure 2-30 COMBINED NEUROENDOCRINE CARCINOMA A: Needle core biopsy of a neck mass shows a mixed oropharyngeal nonkeratinizing SCC (left) with tightly defined nests and larger cells with a little more cytoplasm and small cell carcinoma (center and right More about this image found in COMBINED NEUROENDOCRINE CARCINOMA A: Needle core biopsy of a neck mass sho...
Images
Figure 6-66
Published: 01 June 2025
LYMPHOEPITHELIAL CARCINOMA Figure 6-66 LYMPHOEPITHELIAL CARCINOMA A,B: The biopsy shows a high nuclear to cytoplasmic ratio, malignant epithelioid cells with vesicular nuclei, and distinct nucleoli with a surrounding lymphoplasmacytic infiltrate. C: Malignant cells are positive for CK5/6. More about this image found in LYMPHOEPITHELIAL CARCINOMA A,B: The biopsy shows a high nuclear to cytopla...
Images
Figure 8-41
Published: 01 June 2025
MERKEL CELL CARCINOMA Figure 8-41 MERKEL CELL CARCINOMA A: This punch biopsy demonstrates the deeply infiltrative nature of the tumor, extending into the subcutaneous fat. The adnexal structures are destroyed. B: Large tumor islands are noted in the dermis, with areas of necrosis identified More about this image found in MERKEL CELL CARCINOMA A: This punch biopsy demonstrates the deeply infiltr...
Images
Figure 5-93
Published: 01 June 2025
CENTRAL ODONTOGENIC FIBROMA Figure 5-93 CENTRAL ODONTOGENIC FIBROMA Pericoronal biopsies from patients with odontogenic fibroma hamartoma syndrome appear similar to COF histologically. More about this image found in CENTRAL ODONTOGENIC FIBROMA Pericoronal biopsies from patients with odonto...
Images
Figure 5-196
Published: 01 June 2025
RHABDOMYOSARCOMA WITH TFCP1 REARRANGEMENT (RMS-TFCP2) Figure 5-196 RHABDOMYOSARCOMA WITH TFCP1 REARRANGEMENT (RMS-TFCP2) A: Soft tissue extension of RMS-TFCP2. A biopsy of the soft tissue was sampled to rule out squamous cell carcinoma. B: The biopsy shows a spindle cell More about this image found in RHABDOMYOSARCOMA WITH TFCP1 REARRANGEMENT (RMS-TFCP2) A: ...
Images
Figure 6-17
Published: 01 June 2025
LARYNGEAL AMYLOIDOSIS Figure 6-17 LARYNGEAL AMYLOIDOSIS Low-magnification view of laryngeal amyloidosis on biopsy shows amorphous sheets of densely eosinophilic material, particularly prominent in the upper half of the submucosa. More about this image found in LARYNGEAL AMYLOIDOSIS Low-magnification view of laryngeal amyloidosis on b...
Images
Figure 4-17
Published: 01 June 2025
ERYTHROLEUKOPLAKIA Figure 4-17 ERYTHROLEUKOPLAKIA A: Ill-defined area in the anterior floor of the mouth (black arrows) shows carcinoma in situ (CIS) on biopsy. B: CIS presents as speckled leukoplakia with a central granular area. C: Discrete area of leukoplakia (black arrow) with more More about this image found in ERYTHROLEUKOPLAKIA A: Ill-defined area in the anterior floor of the mouth ...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-4
ISBN: 978-1-933477-61-9
..., mimicking other malignant tumors. Epithelial dysplasia and carcinoma in situ are noted in most cases, although extensive sampling may be required. On small biopsies lacking a surface component, other spindle cell malignancies must be ruled out including melanoma ( 46 ). Cytokeratin markers including...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
... of the tumors and their relationships to vessels, nerves, and skull base, including possible bone erosion. Since the imaging findings are usually diagnostic, biopsy is rarely indicated ( 18 ). Gross Findings. Tumors are ovoid to fusiform and firm, with highly variable cut surfaces that are light brown to tan...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... rheumatoid arthritis or systemic lupus erythematosus are characteristic enough to be diagnostic. Neoplastic conditions such as squamous cell carcinoma (SCC) may be suggested clinically, but tissue biopsy or fine-needle aspiration (FNA) reveals the absence of an epithelial component. Early stage rheumatoid...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
... (for p40, for example) in order to make the diagnosis. However, on small biopsy specimens and, in particular, for tumors where there is limited sampling, crush artifact, or no maturing squamous differentiation, immunostains may be useful to confirm squamous differentiation and exclude small or large cell...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... biopsy. These rests often show cytoplasmic clearing because of the propensity of glycogen to accumulate in the cytoplasm ( fig. 5-8 ). Rests of Serres are likely the histogenetic source of the gingival cyst. Remnants of dental lamina also remain for life within the bone where they are capable of forming...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... for several years, before recurring ( 60 – 62 , 71 , 73 ). Spontaneous resolution is rarely documented ( 77 ). Gross Findings. Most lesions of CNCH are removed by shave biopsy, which shows a small central crater containing yellow to brown necrotic material, clinically matching the crust. Most examples...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
.... The fibrotic/cicatrical stage is marked by dense fibrosis. Microscopic Findings. Rhinoscleroma is most often biopsied in the florid stage. At this stage of the disease, the submucosa is expanded by inflammatory cells including lymphocytes, plasma cells, neutrophils, and histiocytes. Russell bodies, large...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-3
ISBN: 978-1-933477-61-9
... elements and are often associated with SMARCA4 loss ( fig. 3-21 ) ( 109 , 110 ). Given the histologic overlap among some of these entities, adequate tissue sampling is important. In particular, a small biopsy (or inadequately sampled tumor) can complicate the assessment and may result in a diagnostic...
Images
Figure 2-5
Published: 01 December 2024
ADRENAL CORTICAL TISSUE IN A DONOR KIDNEY BIOPSY Figure 2-5 ADRENAL CORTICAL TISSUE IN A DONOR KIDNEY BIOPSY A: Uncircumscribed adrenal cortical tissue was present between the renal capsule and a renal subcortical cyst. A small amount of normal kidney is present at left. The empty space More about this image found in ADRENAL CORTICAL TISSUE IN A DONOR KIDNEY BIOPSY A: Uncircumscribed adrena...
Images
Figure 5-15
Published: 01 December 2024
POST-FINE NEEDLE ASPIRATION BIOPSY INVOLUTIVE CHANGES IN AN INCIDENTAL ADRENAL CORTICAL ADENOMA Figure 5-15 POST-FINE NEEDLE ASPIRATION BIOPSY INVOLUTIVE CHANGES IN AN INCIDENTAL ADRENAL CORTICAL ADENOMA Incidental nonfunctional adrenal cortical adenoma in a 73-year-old man who had gallstones More about this image found in POST-FINE NEEDLE ASPIRATION BIOPSY INVOLUTIVE CHANGES IN AN INCIDENTAL ADRE...
Images
Figure 11-29
Published: 01 December 2024
DIFFERENTIATING NEUROBLASTOMA Figure 11-29 DIFFERENTIATING NEUROBLASTOMA Left adrenal biopsy of 13-month-old boy shows morphologically heterogeneous tumor with varying ganglion cell differentiation, next to areas with neuroblasts, separated by neuropil. More about this image found in DIFFERENTIATING NEUROBLASTOMA Left adrenal biopsy of 13-month-old boy show...
Images
Figure 11-30
Published: 01 December 2024
GANGLIONEUROBLASTOMA INTERMIXED Figure 11-30 GANGLIONEUROBLASTOMA INTERMIXED Biopsy of paravertebral mass in 11-year-old girl shows areas of schwannian stroma, intermingled with areas of immature stroma containing cells with varying differentiation toward ganglion cells, but also including More about this image found in GANGLIONEUROBLASTOMA INTERMIXED Biopsy of paravertebral mass in 11-year-ol...
Images
Figure 11-37
Published: 01 December 2024
NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW Figure 11-37 NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW This trephine biopsy shows extensive involvement by NB, which is even appreciated without immunohistochemistry. More about this image found in NEUROBLASTOMA METASTATIC TO BONE AND BONE MARROW This trephine biopsy show...