SARCOMATOID MESOTHELIOMA: DESMOPLASTIC Figure 3-63 SARCOMATOID MESOTHELIOMA: DESMOPLASTIC Left: Core needle biopsy of pleura shows a bland desmoplastic tumor. There was homozygous loss of p16, without which a diagnosis of malignancy would not be possible. Right: A different area of the same biopsy shows more atypia and hyperchromasia, which led to testing for the CDKN2A deletion. More

SARCOMATOID MESOTHELIOMA: DESMOPLASTIC COMPONENT Figure 3-64 SARCOMATOID MESOTHELIOMA: DESMOPLASTIC COMPONENT There are areas of high as well as low cellularity in this surgical biopsy specimen. More

SPLENOSIS Figure 8-23 SPLENOSIS A: Multiple nodules are present in the left pleural space. B: Biopsy shows predominantly lymphoid stroma. C: CD8 staining highlights splenic vasculature. D: Abdominal imaging review revealed that the spleen was absent, and a history of splenic trauma in a road t... More

DIFFUSE LARGE B-CELL LYMPHOMA ASSOCIATED WITH CHRONIC INFLAMMATION Figure 6-4 DIFFUSE LARGE B-CELL LYMPHOMA ASSOCIATED WITH CHRONIC INFLAMMATION A: Clusters of large dyscohesive cells are present within a pleural biopsy. Necrosis is seen. B: A separate case shows large dyscohesive cells within f... More

MILD PORTAL CHRONIC INFLAMMATION Figure 1-59 MILD PORTAL CHRONIC INFLAMMATION This liver biopsy is from a patient with chronic hepatitis C. More

SINUSOIDAL CONGESTION: SYSTEMIC AUTOIMMUNE DISEASE Figure 1-80 SINUSOIDAL CONGESTION: SYSTEMIC AUTOIMMUNE DISEASE This biopsy was originally signed out as suggesting vascular outflow disease. When work-up revealed no evidence of vascular outflow disease, the case was sent for consultation. This p... More

WEDGE BIOPSY: “SUBCAPSULAR FIBROSIS” Figure 1-88 WEDGE BIOPSY: “SUBCAPSULAR FIBROSIS” There is focal subcapsular fi bro sis in this wedge biopsy, taken from the anterior edge of the liver, but this finding is easily managed and unlikely to lead to overstaging of the fibrosis. More

MILD PERICELLULAR FIBROSIS Figure 1-89 MILD PERICELLULAR FIBROSIS The biopsy shows mild pericellular fibrosis. More

SYPHILIS Figure 3-10 SYPHILIS The biopsy shows mild nonspecific portal inflammation. More

TALC GRANULOMA Figure 4-15 TALC GRANULOMA Left: This liver biopsy was from a patient with a long history of injection drug use. Right: Polarized light. More

SUBFULMINANT HEPATITIS PATTERN: REGENERATIVE NODULES Figure 5-5 SUBFULMINANT HEPATITIS PATTERN: REGENERATIVE NODULES The biopsy shows extensive parenchymal collapse with a single large regenerative nodule (seen in the upper half of the image). More

WILSON DISEASE MIMICKING AUTOIMMUNE HEPATITIS Figure 5-13 WILSON DISEASE MIMICKING AUTOIMMUNE HEPATITIS This biopsy from a 16-year-old male shows a plasma cell-rich acute hepatitis pattern that mimics autoimmune hepatitis, but further workup revealed Wilson disease. More

ALAGILLE SYNDROME: LOSS OF CD10 Figure 6-11 ALAGILLE SYNDROME: LOSS OF CD10 This biopsy is from a 7-year-old patient with an established clinical diagnosis of Alagille syndrome. CD10 shows diminished canalicular staining. More

SMALL DUCT PRIMARY SCLEROSING CHOLANGITIS Figure 7-34 SMALL DUCT PRIMARY SCLEROSING CHOLANGITIS The biopsy findings were typical for PSC, while the bile ducts were normal by imaging studies. More