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in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma
> Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
POST-TREATMENT CHANGE IN NEUROBLASTOMA Figure 11-26 POST-TREATMENT CHANGE IN NEUROBLASTOMA Largely necrotic NB, with focal calcification. The biologic potential of the remaining nucleated tumor cells is frequently difficult to estimate. More about this image found in POST-TREATMENT CHANGE IN NEUROBLASTOMA Largely necrotic NB, with focal cal...
Images
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL CARCINOMA Figure 6-42 PEDIATRIC ADRENAL CORTICAL CARCINOMA This tumor showed capsular (A) and vascular invasion (B,C). Increased mitotic activity and rare atypical mitotic figures were also found. Cytologic atypia was mild as it is usually in pediatric adrenal cortical ... More about this image found in PEDIATRIC ADRENAL CORTICAL CARCINOMA This tumor showed capsular (A) and va...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... are removed. The average weight in large retrospective series varies from 365 to 428 g, with values ranging from 5 to 3,100 g ( 116 , 117 ). Although tumor weight has been reported in the past to predict biologic behavior, there is no evidence that weight accurately predicts malignancy, except in the setting...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... lymphocytic infiltrates, in addition to vital tumor tissue with immature stroma and neuroblasts. POST-TREATMENT CHANGE IN NEUROBLASTOMA Figure 11-26 POST-TREATMENT CHANGE IN NEUROBLASTOMA Largely necrotic NB, with focal calcification. The biologic potential of the remaining nucleated tumor cells...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... ). The compact cells, also called lipid-poor cells, are spherical with eosinophilic cytoplasm. These two cell types are proportionally different in different hormonally active adenomas ( fig. 5-18 ). Nevertheless, the details of hormonal and biological activities of these cells are still largely unknown...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-01
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... or survival ( 4 ). In adults, the adrenal cortex provides about 1 percent of biologically important androgens in men (most are of testicular origin), and roughly half of all androgens in women ( 11 ). Steroid biosynthesis in the adrenal gland is regulated predominantly by pituitary-derived adrenocorticotropic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... steroid therapy and radiographic evaluation was successful in that case ( 36 ). TARTs and hyperplasia have also been noted in patients with Nelson syndrome ( 37 ) and primary Addison disease ( 38 ). Biologic Behavior. Adrenal rest tumors histologically resemble Leydig cell tumors, but have features...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of a syndrome or a coincidence. A prime example is immunohistochemical staining for SDHB showing that PitNET caused by loss of SDHB is rare ( 16 ). However, a hypothetical biologic consideration in these cases is whether a secondary effect of the hereditary mutation indirectly contributes to tumorigenesis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... carcinomas developing in the Li-Fraumeni syndrome or as sporadic forms, but TP53-related cases do not seem to possess peculiar morphologic or biologic characteristics, including hormone secretion properties. Special attention has been dedicated to the TP53 p.R337H variant. Since its first...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... biologically by distinctive characteristics of extra-adrenal versus adrenal tumors. These characteristics include usual inability to synthesize epinephrine and proclivity to occur in patients with hereditary mutations of genes encoding subunits of succinate dehydrogenase ( 33 ); they may reflect the different...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... of uncertain biologic behavior. They often show prominent associated T-cell infiltration and are typically seen against a backdrop of immune suppression (especially HIV infection). Histopathologic features are illustrated in chapter 1 , figure 1-5 . Laboratory Diagnosis EBV infection is associated...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-14
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... individual. This is also the form of disease most likely to be used as a potential biological weapon. Primary pneumonic plague presents with a sudden onset of high-grade fever, cough, dyspnea, pleuritic chest pain, and bloody sputum. Mortality is approximately 90 to 100 percent. Imaging typically shows...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-21
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... malignances, solid organ transplants, and autoimmune disease, and individuals receiving steroids and other immunosuppressive or biological therapies ( 50 ). Figure 21-19 illustrates the life cycle of the fungus. Pneumocystis exists in animal and human tissues in both trophic and cystic (ascus) forms...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-21
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... . Cutaneous collision cancers: a report of two squamomelanocytic malignancies and review of the literature . Dermatol Surg 2011 ; 37 : 1679 - 83 . 23. Leonard N , Wilson N , Calonje JE . Squamomelanocytic tumor: an unusual and distinctive entity of uncertain biological potential...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-15
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... confined to the dermis need less horizontal clearance to ensure complete removal than melanomas with an intraepidermal peripherally extending in situ tumor cell population. REFERENCES REFERENCES 1. Clark WH Jr , From L , Bernardino EA , Mihm MC . The histogenesis and biologic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-19
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... melanoma and biologically indeterminate spitzoid tumors by RNA sequencing . Mod Pathol 2016 ; 29 : 359 - 69 . 8. Gerami P . Spitzoid melanoma . In: Busam KJ , Gerami P , Scolyer RA , eds. Pathology of melanocytic tumors . Philadelphia : Elsevier ; 2019 ; 216 - 25 . 9...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-12
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... assessment is based on the same factors as for other melanomas, i.e., there is no independent prognostic value to the annotation of a melanoma as “superficial spreading type.” REFERENCES REFERENCES 1. Clark WH Jr , From L , Bernardino EA , Mihm MC . The histogenesis and biologic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... “true” Spitz, and whether it is clearly benign, malignant, intermediate, or indeterminate in its appearance and biologic potential ( 10 , 11 ). Integrating molecular findings into the definition of Spitz neoplasms has permitted a more reproducible classification of these lesions ( 11 – 17 ), at least...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-10
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
..., insufficient tissue for ancillary studies), a definitive diagnosis may not be possible. Biphenotypic neoplasms are then reported as atypical melanocytic “tumor” or “proliferation” associated with a nevus, acknowledging uncertainty about the biologic potential of the tumor. TREATMENT AND PROGNOSIS Combined...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-18
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
...-synthesizing melanoma reflect a mixture of bonafide malignant melanomas and indolent melanocytic neoplasms, including “borderline” tumors of indeterminate biologic potential, such as the pigment-synthesizing melanocytic neoplasm with protein kinase c alpha fusion ( 22 ). Mutation analysis can help...
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