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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch20
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... CAUSES OF PORTAL HYPERTENSION Vascular thrombosis Autoimmune hepatitis Alpha-1 antitrypsin deficiency Primary sclerosing cholangitis Steatohepatitis Toxins Storage diseases Hepatitis B and C Primary biliary cirrhosis Right-sided heart failure Cystic fibrosis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch39
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... 10  Other patterns of lobes 5 0 Hepatic sidedness  Midline symmetric liver 60 35  Normal right-sided liver 25 40  Mirror-image left-sided liver 15 25 Position of gallbladder  Right-sided 65 50  Left-sided 25 40  Midline 10 10 Anomaly of biliary...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch33
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... and bile ductular branches within triads, obliterated portal veins, and obstructive biliary changes ( 45 ). Definition.  Budd-Chiari syndrome is caused by the obstruction of hepatic blood outflow at the level of either the hepatic veins or hepatic portion of the inferior vena cava. The former...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch30
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
..., previous terms that denote fibrosclerosing processes in various organs, especially the salivary glands, biliary tree, mesentery, and mediastinum. The one fibrosclerosing aortic inflammatory lesion is adventitial, so-called sclerosing periaortitis, which resembles other IgG4-related processes...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-15
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
..., breast, biliary system, appendix, and other less common sites. Immunohistochemistry helps identify the primary site ( Table 15-2 ) ( 34 ). Gastric signet ring cell adenocarcinomas have variable staining with CK7 and CK20. Approximately half of tumors are CDX2 positive. SATB2 is usually negative, but may...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-03
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... of the 3’ terminal end of EPCAM that results in loss of MSH2 function. General and Clinical Features. Lynch syndrome confers a significantly increased risk of colorectal, endometrial, ovarian, small bowel, stomach, renal pelvis and ureter, biliary, and brain cancers and sebaceous neoplasia...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-14
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
...   W , Ji   H , Zhao   J , et al   Transcriptional repression and apoptosis influence the effect of APO-BEC3A/3B functional polymorphisms on biliary tract cancer risk . Int J Cancer   2022 ; 150 : 1825 - 37 . 31. Chen   Q , Lu   W , Lv   W . Overlap of microcystic stromal...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-16
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... gross tumor dimension to validate the tumor size ( 4 ). A useful section that shows the relationship of the tumor to the ampulla of Vater, the duodenum, the pancreas, and the bile duct is one parallel to the pancreatic and biliary ducts that includes the neoplasm, the duodenal mucosa, the profiles...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-02
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... Precursor Lesions in the Pancreas . Am J Surg Pathol   2015 ; 39 : 1730 - 41 . 14. Vyas   M , Hechtman   JF , Zhang   Y , et al   DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma . Mod Pathol   2020...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-01
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... , Rowe   JS , Gray   SW , Skandalakis   JE . Surgical embryology and anatomy of the pancreas . Surg Clin North Am   1993 ; 73 : 661 - 97 . 82. Lack   EE . Pathology of the pancreas, gallbladder, extrahepatic biliary tract, and ampullary region . Oxford University Press, Inc. ; 2003...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-04
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... four patients died from their disease. The causes of death included gastrointestinal bleeding from erosion of the neoplasm into the duodenum, malabsorption, and obstruction of the biliary tree. More recent studies have documented that complete surgical resection almost always leads to a cure; less than...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-15
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... , Kalayarasan   R , Mishra   PK , Srivastava   S , Chandrasekar   S , Godhi   S . Chronic pancreatitis with benign biliary obstruction: management issues . World J Surg   2014 ; 38 : 2455 - 9 . 16. Detlefsen   S , Sipos   B , Feyerabend   B , Klöppel   G . Fibrogenesis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-14
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
..., including neoplasms of the soft tissues, esophagus, prostate gland, uterine cervix, liver, thyroid gland, biliary tract, small intestine, head and neck, salivary gland, urinary tract, adrenal gland, vulva, ovary, pleura, and skin. Table 14-2 ORIGIN OF PANCREATIC METASTASES IN SURGICAL SERIES...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-08
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas . Virchows Arch   2016 ; 469 : 523 - 32 . 63. Vyas   M , Hechtman   JF , Zhang   Y , et al   DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-06
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... and biliary cancers . Am J Pathol   1999 ; 154 : 1835 - 40 . 59. Denost   Q , Chafai   N , Arrive   L , Mourra   N , Paye   F . Hereditary intraductal papillary mucinous neoplasm of the pancreas . Clin Res Hepatol Gastroenterol   2012 ; 36 : e23 - 5 . 60. Maire   F , Hammel...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... carriers . Gastroenterology   2004 ; 126 : 1788 - 94 . 119. Su   GH , Hruban   RH , Bansal   RK , et al   Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers . Am J Pathol   1999 ; 154 : 1835 - 40 . 120. Midha   S , Sreenivas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-13
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... duct obstruction while those involving the pancreatic parenchyma most commonly (70 percent) present with abdominal pain. The neoplasms often cause symptoms despite the small size on presentation (median size, 0.7 cm; range, 0.5 to 2.0 cm) due to biliary obstruction (when involving the intra-pancreatic...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-09
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
...-with-Wiedemann syndrome, which is also associated with pancreatoblastoma ( 45 , 46 ), has not been reported in acinar cell carcinoma patients. The presenting symptoms of acinar cell carcinoma are usually nonspecific. Since biliary obstruction is uncommon, jaundice is infrequent relative to ductal adenocarcinoma...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-12
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... ) ( 72 ). Nonhypervascular PanNETs are more challenging to distinguish from ductal adenocarcinomas radiographically ( 73 ). Those arising in the head of the pancreas generally do not produce dilatation of the pancreatic or biliary ducts, in contrast to ductal adenocarcinomas. Even large PanNETs...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Published: 01 January 2022
10.55418/9781933477183-6
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... ages. NEONATAL CHOLESTATIC LIVER DISEASE Neonatal cholestasis is usually defined as presentation with jaundice at birth or within the first few months of life. The most common causes of neonatal cholestasis are biliary atresia (about 30 percent of cases), genetic disorders (25 percent...