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PEDIATRIC ADRENAL CORTICAL TUMOR: <span class="search-highlight">BENIGN</span>  Adrenal tumor in a 6-year-old boy...
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Figure 6-40 PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Adrenal tumor in a 6-year-old boy associated with virilization, classified as benign behavior by means of the Wieneke score. The cut surface was homogeneously brown, with no evidence of necrosis or hemor... More about this image found in PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Adrenal tumor in a 6-year-old boy...
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PEDIATRIC ADRENAL CORTICAL TUMOR: <span class="search-highlight">BENIGN</span>  A–C: The tumor is shown at progre...
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Figure 6-41 PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN A–C: The tumor is shown at progressively higher magnification. It lacks necrosis and signs of invasion and showed low mitotic and proliferation indexes. Final Wieneke score was 0. (Same case as fig. 6-4... More about this image found in PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN A–C: The tumor is shown at progre...
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PEDIATRIC ADRENAL CORTICAL TUMOR: <span class="search-highlight">BENIGN</span>  The tumor diffusely expressed SF1...
Published: 01 December 2024
PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN Figure 6-43 PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN The tumor diffusely expressed SF1 (A). Ki-67 index (B) was 5 percent, whereas p53 was expressed in rare nuclei (C). (Same case as figs. 6-40 and 6-41 .) More about this image found in PEDIATRIC ADRENAL CORTICAL TUMOR: BENIGN The tumor diffusely expressed SF1...
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ADRENAL CORTICAL TISSUE IN A CONGENITAL DYSPLASTIC KIDNEY  This dysplastic ...
Published: 01 December 2024
ADRENAL CORTICAL TISSUE IN A CONGENITAL DYSPLASTIC KIDNEY Figure 2-6 ADRENAL CORTICAL TISSUE IN A CONGENITAL DYSPLASTIC KIDNEY This dysplastic kidney removed from a 5-week-old girl contains a prominent focus of benign immature adrenal cortex. More about this image found in ADRENAL CORTICAL TISSUE IN A CONGENITAL DYSPLASTIC KIDNEY This dysplastic ...
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ADRENAL CORTICAL CARCINOMA: ALTERED RETICULIN PATTERNS  Irregular reticulin...
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA: ALTERED RETICULIN PATTERNS Figure 6-28 ADRENAL CORTICAL CARCINOMA: ALTERED RETICULIN PATTERNS Irregular reticulin pattern as highlighted by silver staining techniques, either in the form of “quantitative” changes (large nests disrupting the regular alveolar pattern typ... More about this image found in ADRENAL CORTICAL CARCINOMA: ALTERED RETICULIN PATTERNS Irregular reticulin...
Images
ADRENAL CORTICAL TUMOR IN A PATIENT HARBORING <em>ARMC5</em> GERMLI...
Published: 01 December 2024
ADRENAL CORTICAL TUMOR IN A PATIENT HARBORING ARMC5 GERMLINE VARIANT Figure 7-2 ADRENAL CORTICAL TUMOR IN A PATIENT HARBORING ARMC5 GERMLINE VARIANT The adrenal mass (A) is composed of a peripheral benign macronodular component (A, upper left), and is associated with a central component made of eosinophilic cells (B, lower right) showing malignancy-related features, including increased mitotic activity (B, red circle) for a total Weiss score of 4. More about this image found in ADRENAL CORTICAL TUMOR IN A PATIENT HARBORING ARMC5 GERMLI...
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ADRENAL CORTICAL CARCINOMA ARISING IN ADRENAL CORTICAL ADENOMA  This adrena...
Published: 01 December 2024
ADRENAL CORTICAL CARCINOMA ARISING IN ADRENAL CORTICAL ADENOMA Figure 6-6 ADRENAL CORTICAL CARCINOMA ARISING IN ADRENAL CORTICAL ADENOMA This adrenal lesion, 11 cm in size (same case as shown in fig. 6-1 ), has two distinct areas: a benign one with <10 HU and the malignant one at 30 HU. (A: C... More about this image found in ADRENAL CORTICAL CARCINOMA ARISING IN ADRENAL CORTICAL ADENOMA This adrena...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... from benign to malignant adrenal cortical nodules ( 17 , 18 ). Moreover, even in the sporadic setting, some pathologic and molecular evidence supports that at least a subset of ACCs derive from preexisting adrenal cortical adenomas. Description of cases with a bimodal appearance due to the coexistence...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-07
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... peripheral nerve sheet tumors, benign neural tumors BRCA2 BRCA2 Carcinoma <1% Breast, ovarian, prostate, pancreatic, gastric cancers a See chapter 2 . b MEN1 = multiple endocrine neoplasia 1; HLCC = hereditary leiomyomatosis and renal cell carcinoma; FAP = familial...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Various neoplastic and non-neoplastic lesions cause enlargement of the adrenal glands. Aside from cortical and chromaffin cell tumors, the neoplasms most often encountered are primary benign or malignant tumors arising from non-endocrine cell types that reside in the normal adrenal gland...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-05
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...Adrenal cortical adenoma is a benign neoplasm composed of adrenal cortical steroid hormone-producing cells. EPIDEMIOLOGY Adrenal cortical adenomas are not rare, however, the calculation of their real incidence is biased by the use of the term “nodular hyperplasia” for the entity now...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-02
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... the definitions, applying heterotopic to locations that cannot be explained by usual embryonic development and accessory to those that can. Ectopic adrenal tissue has several implications with regard to tumor diagnosis. Benign adrenal cortical tissue can mimic a variety of clear cell neoplasms, creating...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-08
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... paragangliomas in different locations. A more fundamental conceptual change, first introduced in the 2017 WHO classification and maintained in the more recent 5th edition, is elimination of the previous separate classifications of benign and malignant pheochromocytoma ( 9 ). This concept has now been abandoned...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... neuroendocrine tumors and with the 2017 expert consensus proposal by the WHO and International Agency for Research on Cancer (IARC) aiming to achieve a common classification framework ( 36 ). Accordingly, the previous binary classification into “benign” and “malignant” paragangliomas is no longer employed...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... mature and clinically benign ganglioneuroma (GN). The origin of the adrenal medulla, containing chromaffin cells, and the sympathetic autonomic nervous system, composed of sympathetic neurons, has long been studied and debated. Chromaffin cells were thought to develop from a neural crest...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-04
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
...) The etiology of sporadic nodular adrenocortical disease is largely unknown. Cigarette smoking may be a risk factor since the prevalence of both benign and malignant adrenal cortical neoplasms is higher in individuals with a history of tobacco use ( 10 ). An association between cortical nodularity...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-10
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... hyperplasia, however, they may be more frequently composite tumors containing a benign or malignant neuroblastic component ( 40 ). An unusual case report identified a malignant Triton tumor composed of peripheral nerve sheath tumor and skeletal muscle differentiation in a patient with NF1 ( 41...
Images
ADENOCARCINOMA IN SITU (AIS)  A: Biopsy fragment shows numerous endocervica...
Published: 01 September 2024
ADENOCARCINOMA IN SITU (AIS) Figure 9-38 ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervical glands with AIS predominantly on the right. B: Glands with AIS in the lower half show depleted mucin, several mitoses, and apoptosis. C: P16 is positive in glands with AIS and is... More about this image found in ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervica...
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ADENOCARCINOMA IN SITU (AIS)  A: Biopsy fragment shows numerous endocervica...
Published: 01 September 2024
ADENOCARCINOMA IN SITU (AIS) Figure 9-38 ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervical glands with AIS predominantly on the right. B: Glands with AIS in the lower half show depleted mucin, several mitoses, and apoptosis. C: P16 is positive in glands with AIS and is... More about this image found in ADENOCARCINOMA IN SITU (AIS) A: Biopsy fragment shows numerous endocervica...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... individuals should avoid contact sports due to the risk of splenic rupture (if there is splenomegaly). Benign lymphoid proliferations associated with immunosuppression are managed by alleviating or decreasing the underlying cause of immunocompromise. EBV-associated neoplasia requires therapy directed...