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GRANULOSA CELL TUMOR: JUVENILE TYPE  This follicle is lined by columnar cel...
Published: 01 August 2022
GRANULOSA CELL TUMOR: JUVENILE TYPE Figure 6-140 GRANULOSA CELL TUMOR: JUVENILE TYPE This follicle is lined by columnar cells with basally located nuclei, a rare feature. More
Images
NORMAL FETAL TESTIS  There are numerous Leydig cells between solid seminife...
Published: 01 August 2022
NORMAL FETAL TESTIS Figure 2-36 NORMAL FETAL TESTIS There are numerous Leydig cells between solid seminiferous tubules (or cords) containing immature germ cells and Sertoli cells. The spermatogonia are both centrally and basally located. More
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LOW-GRADE MUCINOUS CYSTADENOCARCINOMA OF TESTIS  Left: There are prominent ...
Published: 01 August 2022
LOW-GRADE MUCINOUS CYSTADENOCARCINOMA OF TESTIS Figure 8-12 LOW-GRADE MUCINOUS CYSTADENOCARCINOMA OF TESTIS Left: There are prominent extravasated mucin and a dilated malignant gland in a desmoplastic stroma. Right: High-power view of a different case shows basally oriented nuclei and apical cyt... More
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PRE-GERM CELL NEOPLASIA IN SITU  Individual atypical cells are located cent...
Published: 01 August 2022
PRE-GERM CELL NEOPLASIA IN SITU Figure 4-28 PRE-GERM CELL NEOPLASIA IN SITU Individual atypical cells are located centrally and parabasally (black arrows), as well as basally (yellow arrow). These cells stained for OCT3/4 and there was also expression of stem cell factor (KIT ligand) in the tubul... More
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EPIDIDYMAL TUBULE  Left: There are two layers of lining epithelium: the tal...
Published: 01 August 2022
EPIDIDYMAL TUBULE Figure 2-47 EPIDIDYMAL TUBULE Left: There are two layers of lining epithelium: the tall, columnar, principal cells and an underlying layer of basal cells. Several layers of smooth muscle surround the tubule. Note the luminal stereocilia. Right: Higher magnification of the same ... More
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GERM CELL NEOPLASIA IN SITU  Left: Clear cells with enlarged nuclei, some w...
Published: 01 August 2022
GERM CELL NEOPLASIA IN SITU Figure 4-17 GERM CELL NEOPLASIA IN SITU Left: Clear cells with enlarged nuclei, some with flattened edges, are aligned along the basal aspect of seminiferous tubules lacking spermatogenesis and having thickened basement membranes. Sertoli cells are present on the adlum... More
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SERTOLIFORM CYSTADENOMA OF RETE TESTIS  A: Solid tubules grow in a dilated ...
Published: 01 August 2022
SERTOLIFORM CYSTADENOMA OF RETE TESTIS Figure 8-55 SERTOLIFORM CYSTADENOMA OF RETE TESTIS A: Solid tubules grow in a dilated rete channel. Normal rete epithelium at the top is stretched over the surface of the tumor. B: Many of the tubules have evident luminal spaces; they are lined by columnar ... More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Publisher: American Registry of Pathology
Published: 01 August 2022
DOI: 10.55418/9781933477220-02
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... life to their usual basal location (the “spermatogonial niche”) within the seminiferous tubules as spermatogonia. Mitotic activity is resumed as the central to peripheral migration occurs, and it is common to find mitotic figures in the gonocytes at the basement membrane as they transition...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Publisher: American Registry of Pathology
Published: 01 August 2022
DOI: 10.55418/9781933477220-04
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... that are aligned along the basal portion of seminiferous tubules (the spermatogonial niche) ( fig. 4-17 ). The nuclei are polygonal, often have a flat, linear appearance along a portion of their periphery, and are significantly larger than those of spermatogonia (median, 9.7 μm versus 6.5 μm [ 5 ]) with one...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Publisher: American Registry of Pathology
Published: 01 August 2022
DOI: 10.55418/9781933477220-06
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... and hyperchromatic, round to oval nuclei, some of which show nucleoli ( fig. 6-139 ). Sometimes, cells with columnar morphology and basally located nuclei line some follicles ( fig. 6-140 ). Other rare patterns or features include papillary growth, areas reminiscent of adult granulosa cell tumor, basaloid morphology...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Publisher: American Registry of Pathology
Published: 01 August 2022
DOI: 10.55418/9781933477220-11
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... with retroperitoneal fibrosis ( 85 ) led to speculation that lymphatic obstruction may play a role in its genesis ( 168 ). One patient had the nevoid basal cell carcinoma syndrome (Gorlin syndrome) ( 185 ). A scrotal ultrasound may demonstrate acoustic shadowing due to the dense fibrotic core and the calcifications...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Publisher: American Registry of Pathology
Published: 01 August 2022
DOI: 10.55418/9781933477220-08
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... and a dilated malignant gland in a desmoplastic stroma. Right: High-power view of a different case shows basally oriented nuclei and apical cytoplasmic mucin. The incidence of serous tumors, more common than mucinous tumors, may be more frequent than the literature suggests, as a critical review...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 12
Publisher: American Registry of Pathology
Published: 01 August 2022
DOI: 10.55418/9781933477220-05
ISBN-10: 1-933477-22-9
ISBN: 978-1-933477-22-0
... is mostly inconspicuous, but may be seen in foci corresponding to the normal proliferative zones of organoid structures, including the basal layer of skin, the base of intestinal crypts, and in the isthmic zone (located between the pit and neck regions) of gastric oxyntic mucosa. It is also found in rare...
Images
EPITHELIOID MESOTHELIOMA:ULTRASTRUCTURE  An electron micrograph shows long,...
Published: 01 June 2022
EPITHELIOID MESOTHELIOMA:ULTRASTRUCTURE Figure 3-95 EPITHELIOID MESOTHELIOMA:ULTRASTRUCTURE An electron micrograph shows long, slender microvilli (white arrows), desmosomes (circle), and basal lamina (black arrows). (Scale bar = 2 µm) (Courtesy of Dr. A. Rogers, London, UK) More
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Publisher: American Registry of Pathology
Published: 01 June 2022
DOI: 10.55418/9781933477190-1
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
... supplying the abdominal wall. These nerves include sensory pain fibers. The visceral peritoneum receives sympathetic nerve fibers only and is devoid of pain fibers. MICROSCOPIC ANATOMY The serosal membranes are lined by a single layer of flattened mesothelial cells that rest on a basal lamina ( fig. 1-1A,B...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Publisher: American Registry of Pathology
Published: 01 June 2022
DOI: 10.55418/9781933477190-5
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
...-CAMTA1 gene fusion, has been reported as a useful marker ( 50 – 52 ). Ultrastructural Findings. Electron microscopy reveals abundant intermediate filaments, micropinocytosis, and Weibel-Palade bodies. The basal lamina surrounding the tumor cells is uninterrupted and cytoplasmic lumens may be seen ( 49...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 11
Publisher: American Registry of Pathology
Published: 01 June 2022
DOI: 10.55418/9781933477190-3
ISBN-10: 1-933477-19-9
ISBN: 978-1-933477-19-0
.... EPITHELIOID MESOTHELIOMA:ULTRASTRUCTURE Figure 3-95 EPITHELIOID MESOTHELIOMA:ULTRASTRUCTURE An electron micrograph shows long, slender microvilli (white arrows), desmosomes (circle), and basal lamina (black arrows). (Scale bar = 2 µm) (Courtesy of Dr. A. Rogers, London, UK) METASTATIC ADENOCARCINOMA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 6
Publisher: American Registry of Pathology
Published: 01 August 2021
DOI: 10.55418/9781933477091-ch07
ISBN-10: 1-933477-09-1
ISBN: 978-1-933477-09-1
... Stage Feature 1 Basal plate myometrial fibers with intervening decidua present 2 Basal plate myometrial fibers without intervening decidua present GRADE 3 PLASMA CELL CHRONIC DECIDUITIS Figure 7-3-1 GRADE 3 PLASMA CELL CHRONIC DECIDUITIS Numerous plasma cells in this decidua basalis...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Publisher: American Registry of Pathology
Published: 01 January 2022
DOI: 10.55418/9781933477183-2
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
... involving precore or basal core promoter regions leading to loss of HBeAG( 10 ). Table 2-2 INTERPRETATION OF HEPATITIS C VIRUS (HCV) TESTING BASED ON CDC GUIDELINES a Test Result Interpretation Follow-up HCV antibody nonreactive Likely HCV-negative HCV RNA testing if clinically...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 10
Publisher: American Registry of Pathology
Published: 01 January 2022
DOI: 10.55418/9781933477183-10
ISBN-10: 1-933477-18-0
ISBN: 978-1-933477-18-3
..., cardiomyopathy, and arthritis. Adults are more likely than children to present with neuropsychiatric problems: tremor is usually the first manifestation, with progression to gait imbalance, dysarthria, drooling, and symptoms resembling Parkinson disease, due to copper deposition in the basal ganglia. The most...