ARRHYTHMOGENIC CARDIOMYOPATHY: MOLECULAR MECHANISMS Figure 17-1 ARRHYTHMOGENIC CARDIOMYOPATHY: MOLECULAR MECHANISMS Arrhythmogenic cardiomyopathy most commonly results from mutations in the genes encoding for desmosomal proteins and Ca2+ handling proteins in the sarcoplasmic reticulum. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY: MOLECULAR MECHANISMS Arrhythmogenic cardiom...

ARRHYTHMOGENIC CARDIOMYOPATHY: INFLAMMATION Figure 17-12 ARRHYTHMOGENIC CARDIOMYOPATHY: INFLAMMATION Inflammation is frequently seen throughout the myocardium in arrhythmogenic cardiomyopathy and may be one of the inciting events for fibrofatty replacement. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY: INFLAMMATION Inflammation is frequently see...

ARRHYTHMOGENIC CARDIOMYOPATHY Figure 17-8 ARRHYTHMOGENIC CARDIOMYOPATHY The fatty replacement is nearly transmural in this example. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY The fatty replacement is nearly transmural i...

ARRHYTHMOGENIC CARDIOMYOPATHY Figure 17-9 ARRHYTHMOGENIC CARDIOMYOPATHY The admixture of fat and fibrosis throughout the wall is evident at high-power magnification. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY The admixture of fat and fibrosis throughout...

ARRHYTHMOGENIC CARDIOMYOPATHY Figure 17-2 ARRHYTHMOGENIC CARDIOMYOPATHY Grossly, the anterior surface demonstrates prominent right ventricular (RV) dilatation with a fatty appearance. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY Grossly, the anterior surface demonstrates p...

ARRHYTHMOGENIC CARDIOMYOPATHY Figure 17-7 ARRHYTHMOGENIC CARDIOMYOPATHY Prominent fatty replacement is seen at low-power magnification, with little remaining myocardium in this section. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY Prominent fatty replacement is seen at low-p...

ARRHYTHMOGENIC CARDIOMYOPATHY Figure 17-5 ARRHYTHMOGENIC CARDIOMYOPATHY The fatty replacement of the right ventricular wall is transmural, with no visible muscle outside of the papillary muscles in this example. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY The fatty replacement of the right ventricul...

ARRHYTHMOGENIC CARDIOMYOPATHY Figure 17-10 ARRHYTHMOGENIC CARDIOMYOPATHY A Masson trichrome stain highlights the degree to which fat and fibrosis play a role in replacing the involved myocardium. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY A Masson trichrome stain highlights the degr...

ARRHYTHMOGENIC CARDIOMYOPATHY Figure 17-3 ARRHYTHMOGENIC CARDIOMYOPATHY In short-axis view, the right ventricle is markedly dilated, with extensive fatty replacement of the wall and focal aneurysm (yellow arrow) formation. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY In short-axis view, the right ventricle is m...

ARRHYTHMOGENIC CARDIOMYOPATHY Figure 17-4 ARRHYTHMOGENIC CARDIOMYOPATHY In short-axis view, the right vetricle (RV) is replaced by fat, with just a small amount of grossly identifiable RV myocardium in the inferoseptal region. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY In short-axis view, the right vetricle (RV) ...

ARRHYTHMOGENIC CARDIOMYOPATHY: LEFT VENTRICULAR INVOLVEMENT Figure 17-11 ARRHYTHMOGENIC CARDIOMYOPATHY: LEFT VENTRICULAR INVOLVEMENT Involvement of the left ventricle by fibrofatty replacement is seen, frequently involving the epicardial half of the ventricle first. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY: LEFT VENTRICULAR INVOLVEMENT Involvement of...

ARRHYTHMOGENIC CARDIOMYOPATHY: LEFT VENTRICULAR INVOLVEMENT Figure 17-6 ARRHYTHMOGENIC CARDIOMYOPATHY: LEFT VENTRICULAR INVOLVEMENT In addition to the right ventricular involvement, the left ventricle is also involved by fibrofatty replacement, which is nearly transmural along the lateral wall. More about this image found in ARRHYTHMOGENIC CARDIOMYOPATHY: LEFT VENTRICULAR INVOLVEMENT In addition to...

UHL ANOMALY Figure 17-13 UHL ANOMALY The ventricular wall is devoid of muscle, showing endocardium (black arrow) directly opposed to epicardial fat. This complete lack of muscle in the wall is different than the pathology seen in arrhythmogenic cardiomyopathy. More about this image found in UHL ANOMALY The ventricular wall is devoid of muscle, showing endocardium ...