OVARIAN THECAL METAPLASIA Figure 1-36 OVARIAN THECAL METAPLASIA Ovarian thecal metaplasia appears as a broad zone of bland spindle cells. Nests of pale-staining cortical cells are present within the spindle cell component. More about this image found in OVARIAN THECAL METAPLASIA Ovarian thecal metaplasia appears as a broad zon...

ADRENAL LYMPHANGIOMA Figure 12-11 ADRENAL LYMPHANGIOMA A: The tumor appears as a multilocular cyst filled in part by proteinaceous fluid. The cyst had clear watery contents. Portions of adrenal gland are splayed over the tumor surface. B: Lymphangioma has a cavernous (or cystic) architecture wit... More about this image found in ADRENAL LYMPHANGIOMA A: The tumor appears as a multilocular cyst filled in...

VARIED APPEARANCES OF ADRENAL PECOMA Figure 12-15 VARIED APPEARANCES OF ADRENAL PECOMA A: Sharply circumscribed areas of eosinophilic spindle cells and uniform clear cells resemble renal cell carcinoma. B: Different area of the same tumor shows a markedly varied population of small and ballooned... More about this image found in VARIED APPEARANCES OF ADRENAL PECOMA A: Sharply circumscribed areas of eos...

ABDOMINAL PARAGANGLIOMA Figure 9-25 ABDOMINAL PARAGANGLIOMA This tumor is composed of monomorphic cells with slightly eosinophilic cytoplasm and prominent vacuoles creating a pseudoacinar appearance. This appearance is often associated with SDHB mutation. More about this image found in ABDOMINAL PARAGANGLIOMA This tumor is composed of monomorphic cells with s...

PHEOCHROMOCYTOMA ASSOCIATED WITH VON HIPPEL-LINDAU DISEASE (VHL): EXTENSIVE LIPID DEGENERATION Figure 8-12 PHEOCHROMOCYTOMA ASSOCIATED WITH VON HIPPEL-LINDAU DISEASE (VHL): EXTENSIVE LIPID DEGENERATION The gross appearance of this tumor is bright yellow, resembling an adrenal cortical neoplasm. T... More about this image found in PHEOCHROMOCYTOMA ASSOCIATED WITH VON HIPPEL-LINDAU DISEASE (VHL): EXTENSIVE...

PIGMENTED PHEOCHROMOCYTOMA Figure 8-32 PIGMENTED PHEOCHROMOCYTOMA The accumulation of melanin in the tumor cells can mimic melanoma and these tumors can appear black on gross examination. More about this image found in PIGMENTED PHEOCHROMOCYTOMA The accumulation of melanin in the tumor cells ...

PHEOCHROMOCYTOMA: INTRACYTOPLASMIC HYALINE GLOBULES Figure 8-30 PHEOCHROMOCYTOMA: INTRACYTOPLASMIC HYALINE GLOBULES Scattered tumor cells harbor large round cytoplasmic globules with a hyaline appearance. More about this image found in PHEOCHROMOCYTOMA: INTRACYTOPLASMIC HYALINE GLOBULES Scattered tumor cells ...

PHEOCHROMOCYTOMA ASSOCIATED WITH VHL: LIPID DEGENERATION Figure 8-19 PHEOCHROMOCYTOMA ASSOCIATED WITH VHL: LIPID DEGENERATION There is extensive lipid degeneration of the stroma (see gross appearance in fig. 8-12 ). More about this image found in PHEOCHROMOCYTOMA ASSOCIATED WITH VHL: LIPID DEGENERATION There is extensiv...

ARTIFACTUAL FISSURE FORMATION IN A NORMAL ADRENAL GLAND Figure 1-34 ARTIFACTUAL FISSURE FORMATION IN A NORMAL ADRENAL GLAND Autolysis at a plane roughly between cortex and medulla can create the appearance of an empty sac. More about this image found in ARTIFACTUAL FISSURE FORMATION IN A NORMAL ADRENAL GLAND Autolysis at a pla...

ADRENAL CORTICAL CARCINOMA Figure 6-15 ADRENAL CORTICAL CARCINOMA Most tumor cells in this case have large, coarse cytoplasmic vacuoles, which distend many cells and displace the nucleus to the periphery. Some cells have a “signet ring” appearance. More about this image found in ADRENAL CORTICAL CARCINOMA Most tumor cells in this case have large, coars...

ADRENAL GLAND FROM A 35-WEEK PREMATURE INFANT Figure 1-18 ADRENAL GLAND FROM A 35-WEEK PREMATURE INFANT In this transverse section, much of the fetal or provisional cortex has a dark appearance. This may be a normal feature and should not be confused with adrenal hemorrhage. More about this image found in ADRENAL GLAND FROM A 35-WEEK PREMATURE INFANT In this transverse section, ...

ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Figure 5-11 ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA On cross section, the tumor is sharply demarcated and appears encapsulated, particularly where it expands the contours of the adrenal capsule. The tumor measured 1 cm in diameter and is a uni... More about this image found in ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA On cross section, the tumor...

ADRENAL NEUROBLASTOMA Figure 11-10 ADRENAL NEUROBLASTOMA A: Cross-section of a 174-g adrenal NB from a 5-month-old boy. There is extensive calcification within the tumor, which appears as yellowish coarse granular areas. B: Specimen radiograph with identical orientation shows extensive foci of d... More about this image found in ADRENAL NEUROBLASTOMA A: Cross-section of a 174-g adrenal NB from a 5-mont...

S-100 PROTEIN IN DEVELOPING FETAL ADRENAL GLAND Figure 1-14 S-100 PROTEIN IN DEVELOPING FETAL ADRENAL GLAND Some S-100 protein-positive cells are present at the periphery of a small neuroblastic aggregate (right), while others are associated with scattered more mature-appearing cells with clear c... More about this image found in S-100 PROTEIN IN DEVELOPING FETAL ADRENAL GLAND Some S-100 protein-positiv...

ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Figure 5-38 ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Spironolactone bodies appear as eosinophilic inclusions (arrows) within the cytoplasm of zona glomerulosa cells and are often surrounded by a clear halo (A). Due to their rich content of phos... More about this image found in ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Spironolactone bodies appea...

CUSHING DISEASE Figure 3-8 CUSHING DISEASE Histology of left (upper panels) and right (lower panels) adrenal glands from a patient with a recurrent ACTH-secreting pituitary tumor (same case as fig. 3-3 ). Both glands show a similar morphologic appearance, with a homogeneous increase of cortical ... More about this image found in CUSHING DISEASE Histology of left (upper panels) and right (lower panels) ...

PRIMARY ADRENAL HEMANGIOMA GROSSLY MIMICKING A RESOLVING HEMATOMA Figure 12-6 PRIMARY ADRENAL HEMANGIOMA GROSSLY MIMICKING A RESOLVING HEMATOMA A: The gross appearance of this retracted fibrinous and hemorrhagic lesion is suggestive of a resolving hematoma. B: Histologic sections show resolving ... More about this image found in PRIMARY ADRENAL HEMANGIOMA GROSSLY MIMICKING A RESOLVING HEMATOMA A: The g...

ADRENAL CORTICAL CARCINOMA Figure 6-2 ADRENAL CORTICAL CARCINOMA This adrenal cortical carcinoma shows a gross nodule-in-nodule appearance (A). Peripheral areas are well circumscribed with oncocytic features (B). A thin capsule (C) separates the peripheral areas from a central component with an a... More about this image found in ADRENAL CORTICAL CARCINOMA This adrenal cortical carcinoma shows a gross n...

BODY AND HEAD OF NORMAL ADRENAL GLAND Figure 1-23 BODY AND HEAD OF NORMAL ADRENAL GLAND In this transverse section, the medullary compartment appears dull gray in contrast to the bright yellow cortex. Partial to complete cuffs of cortex are present around the central adrenal vein and its tributar... More about this image found in BODY AND HEAD OF NORMAL ADRENAL GLAND In this transverse section, the medu...

ECTOPIC ACTH SYNDROME Figure 3-6 ECTOPIC ACTH SYNDROME Transverse sections of adrenal glands surgically resected from a patient with ectopic ACTH syndrome due to a bronchial neuroendocrine tumor. The tumor had remained occult for several years. The right adrenal gland weighed 12 g and the left 11... More about this image found in ECTOPIC ACTH SYNDROME Transverse sections of adrenal glands surgically res...