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Images
Figure 1-123
Published: 01 June 2025
ANGIOSARCOMA Figure 1-123 ANGIOSARCOMA A: Pleomorphic epithelioid cells form blood-filled vascular spaces. B: Endothelial markers like CD31 (pictured here), CD34, and ERG are confirmatory. More about this image found in ANGIOSARCOMA A: Pleomorphic epithelioid cells form blood-filled vascular s...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... straightforward. When secondary fibrin deposition is prominent, amyloidosis may be a consideration. Genuine amyloid is positive for Congo red with apple-green birefringence, in contrast to fibrin. In angiomatous polyps where recanalizing vessels are particularly striking, a vascular neoplasm such as angiosarcoma...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... to either angiosarcoma or adenocarcinoma. It represents less than 4 percent of SCCs ( 200 ). It was first described by Lever in 1947 ( 201 ) as adenoacanthoma of sweat glands in sun-exposed skin including the face and scalp where it is more common. Clinically, it is like conventional SCC, and approximately...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
..., Langerhans cell histiocytosis, angiosarcoma, and even metastatic papillary thyroid carcinoma. Granulation tissue lacks prominent endothelial cells, is haphazard, and generally shows more acute inflammation without prominent eosinophils or germinal centers. Papillary endothelial hyperplasia develops within...
Images
Figure 12-10
Published: 01 December 2024
PRIMARY ADRENAL ANGIOSARCOMA Figure 12-10 PRIMARY ADRENAL ANGIOSARCOMA A: There is well-developed vasoformative architecture with sinusoidal growth between cords of vacuolated cortical cells. Acute inflammatory cells and eosinophils are also present. B: Primary adrenal angiosarcoma (same case More about this image found in PRIMARY ADRENAL ANGIOSARCOMA A: There is well-developed vasoformative arch...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... is suggestive of a resolving hematoma. B: Histologic sections show resolving hemorrhage (top left) associated with a capillary hemangioma. The tumor is traversed by a nerve within the adrenal medulla. A massive hemorrhagic adrenal cortical adenoma has been reported mimicking an angiosarcoma ( 24 ). Conversely...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-06
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... to be excluded are soft tissue tumors with epithelioid appearance and possible malignancy related features, such as angiosarcoma, solitary fibrous tumor, and PEComas. SCHEMATIC DIAGNOSTIC ALGORITHM FOR ADRENAL CORTICAL CARCINOMA DIAGNOSIS Figure 6-36 SCHEMATIC DIAGNOSTIC ALGORITHM FOR ADRENAL CORTICAL...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch54
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...Table 54-1 GENES IMPLICATED IN CARDIAC ANGIOSARCOMA POT1 KDR PLCG1 TP53 CDKN2A/B KRAS KMT2D PLCG1 NRAS MYC CARDIAC ANGIOSARCOMA: BIPHASIC TYPE Figure 54-13 CARDIAC...
Images
Figure 11-25
Published: 01 January 2024
ANGIOSARCOMA Figure 11-25 ANGIOSARCOMA A: Low-power image of an angiosarcoma in which vascular channels are seen infiltrating through the dermis. B: At intermediate power, the interanastomosing channels as well as the cytologic atypia of the endothelial cells are appreciated. C: At high power More about this image found in ANGIOSARCOMA A: Low-power image of an angiosarcoma in which vascular chann...
Images
Figure 11-27
Published: 01 January 2024
ANGIOSARCOMA Figure 11-27 ANGIOSARCOMA A: Low-power view of another angiosarcoma with spindle cell morphology. B,C: Intermediate- (B) and high-power (C) views show the nuclear atypia of the spindle cells, mitotic figures, and some red blood cells. CD31 and ERG were positive in the spindle cells. More about this image found in ANGIOSARCOMA A: Low-power view of another angiosarcoma with spindle cell m...
Images
Figure 11-29
Published: 01 January 2024
ANGIOSARCOMA Figure 11-29 ANGIOSARCOMA A: Low-power image of a subtle variant of angiosarcoma mimicking radiation dermatitis. The cells of concern are seen at the left hand side of the field. B: High-power view shows the scattered highly atypical endothelial cells of angiosarcoma. C: Another More about this image found in ANGIOSARCOMA A: Low-power image of a subtle variant of angiosarcoma mimick...
Images
Figure 11-28
Published: 01 January 2024
EPITHELIOID ANGIOSARCOMA Figure 11-28 EPITHELIOID ANGIOSARCOMA This image illustrates how epithelioid in appearance some angiosarcomas can be, mimicking both poorly differentiated carcinoma and metastatic melanoma. More about this image found in EPITHELIOID ANGIOSARCOMA This image illustrates how epithelioid in appeara...
Images
Figure 11-24
Published: 01 January 2024
ANGIOSARCOMA Figure 11-24 ANGIOSARCOMA This image illustrates the frequent finding of varied patterns of differentiation within the same lesion. On the left side of the image, the angiosarcoma could be classified as well-differentiated; on the right side of the image, the growth pattern is solid More about this image found in ANGIOSARCOMA This image illustrates the frequent finding of varied pattern...
Images
Figure 11-26
Published: 01 January 2024
ANGIOSARCOMA Figure 11-26 ANGIOSARCOMA A: Low-power view demonstrates a solid sheet of spindle cells with areas of hemorrhage (“blood lakes”). B: High power shows the highly atypical spindle cells with brisk mitotic activity. C,D: ERG (C) and MYC (D) immunostains. Clinical history More about this image found in ANGIOSARCOMA A: Low-power view demonstrates a solid sheet of spindle cells...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-11
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... the hyperchromatic nuclei of the endothelial cells, some of which protrude into the vascular lumen. A MYC immunostain was negative. ANGIOSARCOMA Figure 11-25 ANGIOSARCOMA A: Low-power image of an angiosarcoma in which vascular channels are seen infiltrating through the dermis. B: At intermediate power...
Images
Figure 8-61
Published: 01 January 2024
angiosarcoma. C: Careful inspection reveals foci in which the spindle cells coalesce into epithelioid aggregates. D: A keratin (CK903) immunostain is strongly positive, confirming the diagnosis of metaplastic carcinoma. More about this image found in METAPLASTIC CARCINOMA, ACANTHOLYTIC PATTERN A: This tumor is composed of s...
Images
Figure 54-10
Published: 15 November 2023
CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM Figure 54-10 CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM A,B: Spindle cell (A) and epithelioid (B) angiosarcoma. C,D: ERG reactivity within spindle cell angiosarcoma (C) and epithelioid angiosarcoma (D). E,F: CD31 reactivity in spindle cell More about this image found in CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM A,B: Spindle cell (A) and epith...
Images
Figure 54-10
Published: 15 November 2023
CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM Figure 54-10 CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM A,B: Spindle cell (A) and epithelioid (B) angiosarcoma. C,D: ERG reactivity within spindle cell angiosarcoma (C) and epithelioid angiosarcoma (D). E,F: CD31 reactivity in spindle cell More about this image found in CARDIAC ANGIOSARCOMA: MORPHOLOGIC SPECTRUM A,B: Spindle cell (A) and epith...
Images
Figure 54-13
Published: 15 November 2023
CARDIAC ANGIOSARCOMA: BIPHASIC TYPE Figure 54-13 CARDIAC ANGIOSARCOMA: BIPHASIC TYPE Areas of both spindle cells and epithelioid cells are evident in this variety of angiosarcoma. More about this image found in CARDIAC ANGIOSARCOMA: BIPHASIC TYPE Areas of both spindle cells and epithe...
Images
Figure 54-3
Published: 15 November 2023
CARDIAC ANGIOSARCOMA Figure 54-3 CARDIAC ANGIOSARCOMA Basal short-axis view from an autopsy specimen shows an infiltrating mass (yellow arrow) within the right atrioventricular groove. Hemopericardium (yellow asterisk) is also seen, a common complication of cardiac angiosarcoma with compression More about this image found in CARDIAC ANGIOSARCOMA Basal short-axis view from an autopsy specimen shows ...