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Figure 7-36

METASTATIC NONPAPILLARY THYROID CARCINOMA TO LEVELS V, VI, AND VII Metasta...

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in Neck > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
METASTATIC NONPAPILLARY THYROID CARCINOMA TO LEVELS V, VI, AND VII Figure 7-36 METASTATIC NONPAPILLARY THYROID CARCINOMA TO LEVELS V, VI, AND VII Metastatic anaplastic thyroid carcinoma (A), and metastatic medullary thyroid carcinoma (B). (Papanicolaou stains) More about this image found in METASTATIC NONPAPILLARY THYROID CARCINOMA TO LEVELS V, VI, AND VII Metasta...
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Figure 2-12

HPV-ASSOCIATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA WITH TUMOR CELL ANAPLA...

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in Oropharynx > Tumors of the Upper Aerodigestive Tract, Ear, and Jaw
Published: 01 June 2025
HPV-ASSOCIATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA WITH TUMOR CELL ANAPLASIA AND MULTINUCLEATION Figure 2-12 HPV-ASSOCIATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA WITH TUMOR CELL ANAPLASIA AND MULTINUCLEATION A: In anaplastic tumor cells, particularly in neck lymph node dissection specimens More about this image found in HPV-ASSOCIATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA WITH TUMOR CELL ANAPLA...
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Neck

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-7
ISBN: 978-1-933477-61-9
... lymphoma, follicular lymphoma, Hodgkin lymphoma, small lymphocytic lymphoma/chronic lymphocytic lymphoma, mantle cell lymphoma, and nodal marginal zone lymphoma ( 39 ). Less common types include Burkitt lymphoma, anaplastic large cell lymphoma, and NK/T-cell lymphoma...
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Oropharynx

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-2
ISBN: 978-1-933477-61-9
... CARCINOMA WITH TUMOR CELL ANAPLASIA AND MULTINUCLEATION Figure 2-12 HPV-ASSOCIATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA WITH TUMOR CELL ANAPLASIA AND MULTINUCLEATION A: In anaplastic tumor cells, particularly in neck lymph node dissection specimens, the nuclei are 4 to 5 times larger in diameter than...
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Sinonasal Cavity

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-1
ISBN: 978-1-933477-61-9
... necrosis, and increased ganglion-like cells, then malignant behavior is more likely ( 505 , 538 , 611 ). Immunohistochemical Findings. Most head and neck IMTs, especially in patients less than 40 years of age, show ALK immunoreactivity ( fig. 1-113 ), a finding that correlates with anaplastic lymphoma...
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Hypopharynx, Larynx, and Trachea

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-6
ISBN: 978-1-933477-61-9
... laryngeal inflammatory myofibroblastic tumors: misleading lesions: description of six cases showing ALK overexpression . Am J Clin Pathol   2015 ; 144 : 511 - 6 . 292. Mossé   YP , Voss   SD , Lim   MS , et al . Targeting ALK sith Crizotinib in pediatric anaplastic large cell lymphoma...
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Ear and Temporal Bone

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-8
ISBN: 978-1-933477-61-9
... and immunohistochemical features of embryonic skeletal muscle ( 477 , 478 ). Subtypes include spindled, botryoid, and anaplastic patterns, but these subtypes are seldom seen in the ear and temporal bone. Numerous synonyms have been applied in the past, but should be discouraged and discontinued in favor of ERMS. Past...
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Jaw

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 22
Published: 01 June 2025
10.55418/9781933477619-5
ISBN: 978-1-933477-61-9
... osteoblastic (even epithelioid), to spindled, to chondroblastic ( 735 – 738 ). Cytologically, the cells range from undifferentiated to anaplastic to well differentiated, as in well-differentiated intramedullary osteosarcoma. Regardless of the heterogeneity of the sarcomatous component, the sine qua non...
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Images
Figure 11-15

ANAPLASTIC NEUROBLASTOMA The tumor cells have pleomorphic, hyperchromatic ...

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in Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma > Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia
Published: 01 December 2024
ANAPLASTIC NEUROBLASTOMA Figure 11-15 ANAPLASTIC NEUROBLASTOMA The tumor cells have pleomorphic, hyperchromatic nuclei. More about this image found in ANAPLASTIC NEUROBLASTOMA The tumor cells have pleomorphic, hyperchromatic ...
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Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-11
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... cancer-related mortality, according to Surveillance, Epidemiology, and End Result (SEER) data ( 22 ). Familial cases exist in NBL but are rare (1 to 2 percent of cases) ( 23 ). There are two genes that predispose for familial NBL: anaplastic lymphoma kinase (ALK), in which germline gain...
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Lymph Nodes and Bone Marrow

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-08
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... and elongated nuclei, typically with little pleomorphism and scant mitoses. Cutaneous KS demonstrates progression through a patch, plaque, and nodular stage. A bewildering array of morphologic tumor subtypes have been described ( 29 ). These include anaplastic, telangiectatic, lymphedematous, hyperkeratotic...
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Figure 12-5

BREAST IMPLANT-ASSOCIATED ANAPLASTIC LARGE CELL LYMPHOMA (BIA-ALCL) A: Low...

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in Rare Lesions > Tumors of the Mammary Gland
Published: 01 January 2024
BREAST IMPLANT-ASSOCIATED ANAPLASTIC LARGE CELL LYMPHOMA (BIA-ALCL) Figure 12-5 BREAST IMPLANT-ASSOCIATED ANAPLASTIC LARGE CELL LYMPHOMA (BIA-ALCL) A: Low-power image of a cell block preparation from a fluid collection that had accumulated around a breast implant. The specimen is highly cellular More about this image found in BREAST IMPLANT-ASSOCIATED ANAPLASTIC LARGE CELL LYMPHOMA (BIA-ALCL) A: Low...
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Rare Lesions

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-12
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... demonstrates sheets of tumor cells with granular pink cytoplasm, round nuclei, and small nucleoli. BREAST IMPLANT-ASSOCIATED ANAPLASTIC LARGE CELL LYMPHOMA (BIA-ALCL) Figure 12-5 BREAST IMPLANT-ASSOCIATED ANAPLASTIC LARGE CELL LYMPHOMA (BIA-ALCL) A: Low-power image of a cell block preparation from a fluid...
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Lentigo Maligna Melanoma

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-13
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... to the possibility of a rare collision scenario (e.g., LM colliding with an atypical fibroxanthoma, sarcoma, poorly differentiated carcinoma, or anaplastic large cell lymphoma), in which case immunohistochemistry is essential to establish the correct diagnosis. Lack of immunoreactivity for melanocyte differentiation...
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Inflammatory and Reactive Conditions

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-02
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... estimate of breast implant-associated anaplastic large cell lymphoma in textured breast implants . Plast Reconstr Surg   2019 ; 143 ( 3S ): 30S - 40S . 34. Kasper   CS . Histologic features of breast capsules reflect surface configuration and composition of silicone bag implants . Am J Clin...
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Mesenchymal Lesions

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-11
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... . Solitary fibrous tumor of breast with anaplastic areas (malignant solitary fibrous tumor): a case report with review of literature . J Breast Cancer   2019 ; 22 : 326 - 35 . 39. Magro   G , Angelico   G , Leone   G , Palazzo   J . Solitary fibrous tumor of the breast: report of a case...
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Pathologic Evaluation and Reporting of Breast and Axillary Lymph Node Specimens

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-15
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
..., such as serous carcinoma from the ovary or peritoneum or metastatic melanoma (see chapter 12 ), or epithelioid-appearing tumors primary to the breast, for example, epithelioid angiosarcoma and anaplastic large cell lymphoma. The latter three examples are ER-, PR-, and HER2-negative malignancies, and can lead...
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Cardiac Inflammatory Myofibroblastic Tumor

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch50
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... ). Only one reported case expressed desmin ( 15 ). Variable expression may also be seen with calponin and muscle-specific antigen (MSA). No published case of cardiac IMT has documented definitive immunohistochemical evidence of anaplastic lymphoma kinase 1 (ALK-1) expression ( 8 ). One tumor was tested...
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Images
Figure 8-6

MURAL NODULES A: Sarcoma-like mural nodule is well-circumscribed, with a p...

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in Mucinous Ovarian Tumors > Tumors of the Ovary and Fallopian Tube
Published: 01 August 2023
MURAL NODULES Figure 8-6 MURAL NODULES A: Sarcoma-like mural nodule is well-circumscribed, with a prominent inflammatory infiltrate and osteoclast-like giant cells. B,C: Sarcomatous nodule with cells that are frankly malignant, based on their cytological features. D–F: Anaplastic carcinoma More about this image found in MURAL NODULES A: Sarcoma-like mural nodule is well-circumscribed, with a p...
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Seromucinous Tumors

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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-10
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... . 7. Okumura   T , Muronosono   E , Tsubuku   M , Terao   Y , Takeda   S , Maruyama   M . Anaplastic carcinoma in ovarian seromucinous cystic tumor of borderline malignancy . J Ovarian Res   2018 ; 11 : 77 . 8. Storm   HH . Second primary cancer after treatment...
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