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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-12
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... of adrenal enlargement include hemorrhages, cysts, amyloidosis, infections, and noninfectious inflammatory conditions. Each of these entities can be confusing both clinically and radiologically. In some cases, the clinical context and imaging characteristics allow for a presumptive diagnosis ( 1 – 3...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-15
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... Infectious Tuberculosis Syphilis Yaws Fungal infections (e.g., tinea, blastomycosis) Leishmaniasis Granuloma annulare Sarcoidosis Morphea Sweet syndrome Pyoderma gangrenosum Lupus erythematosus Neoplastic/paraneoplastic Lymphoma Basal cell carcinoma Systemic amyloidosis Table 15-9 ETIOLOGIC SPECIES...
Images
Figure 25-9
Published: 15 November 2023
NODAL AMYLOIDOSIS Figure 25-9 NODAL AMYLOIDOSIS This sulfated Alcian blue stain shows amyloidosis of the AV node and the AV nodal artery. More about this image found in NODAL AMYLOIDOSIS This sulfated Alcian blue stain shows amyloidosis of the...
Images
Figure 21-14
Published: 15 November 2023
CARDIAC AMYLOIDOSIS: DEPOSITION PATTERNS Figure 21-14 CARDIAC AMYLOIDOSIS: DEPOSITION PATTERNS Deposition patterns of cardiac amyloidosis shown are pericellular-type (A), nodular (B), obstructive microinvasive (C), and endocardial (D). (All: sulfated Alcian blue staining.) More about this image found in CARDIAC AMYLOIDOSIS: DEPOSITION PATTERNS Deposition patterns of cardiac am...
Images
Figure 21-11
Published: 15 November 2023
AMYLOIDOSIS Figure 21-11 AMYLOIDOSIS A: Four-chamber view shows thickened ventricular walls with pale mottling (asterisks) in the basal walls and endocardium corresponding to areas with dense amyloid deposition. B: The valvular surfaces have a gristly or stippled character (arrows) in regions More about this image found in AMYLOIDOSIS A: Four-chamber view shows thickened ventricular walls with pa...
Images
Figure 21-12
Published: 15 November 2023
CARDIAC AMYLOIDOSIS Figure 21-12 CARDIAC AMYLOIDOSIS The eosinophilic material deposits within the interstitium and has a cracked appearance. More about this image found in CARDIAC AMYLOIDOSIS The eosinophilic material deposits within the intersti...
Images
Figure 21-13
Published: 15 November 2023
AMYLOIDOSIS: STAINS Figure 21-13 AMYLOIDOSIS: STAINS A: Congo red stains amyloid red, as seen by standard light microscopy (left), exhibiting a characteristic apple-green birefringence when viewed in cross-polarized light (right). Collagen has a white birefringence pattern, not to be confused More about this image found in AMYLOIDOSIS: STAINS A: Congo red stains amyloid red, as seen by standard l...
Images
Figure 21-13
Published: 15 November 2023
AMYLOIDOSIS: STAINS Figure 21-13 AMYLOIDOSIS: STAINS A: Congo red stains amyloid red, as seen by standard light microscopy (left), exhibiting a characteristic apple-green birefringence when viewed in cross-polarized light (right). Collagen has a white birefringence pattern, not to be confused More about this image found in AMYLOIDOSIS: STAINS A: Congo red stains amyloid red, as seen by standard l...
Images
Figure 21-16
Published: 15 November 2023
AMYLOIDOSIS: GIANT CELL REACTION Figure 21-16 AMYLOIDOSIS: GIANT CELL REACTION Giant cell reaction to interstitial amyloid deposition, the significance of which is unknown. More about this image found in AMYLOIDOSIS: GIANT CELL REACTION Giant cell reaction to interstitial amylo...
Images
Figure 21-17
Published: 15 November 2023
AMYLOIDOSIS: ULTRASTRUCTURE Figure 21-17 AMYLOIDOSIS: ULTRASTRUCTURE The amyloid fibrils (asterisk) consist of 7- to 10-nm nonbranching fibrils depositing in the extracellular space. More about this image found in AMYLOIDOSIS: ULTRASTRUCTURE The amyloid fibrils (asterisk) consist of 7- t...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch21
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... Hereditary ( 66 ) AApoAIV Apolipoprotein A-IV Systemic Acquired ( 67 ) AGel Gelsolin Systemic Hereditary ( 68 ) AANF Atrial natriuretic factor Localized Acquired Atrial fibrillation ( 40 ) ALys Lysozyme Systemic Hereditary ( 69 ) ALECT2 Amyloidosis derived from leukocyte...
Images
Figure 21-19
Published: 15 November 2023
LIGHT CHAIN DEPOSITION DISEASE: ULTRASTRUCTURE Figure 21-19 LIGHT CHAIN DEPOSITION DISEASE: ULTRASTRUCTURE The granular deposits along the sarcoplasmic membrane are characteristic. Light chain deposition disease does not have the fibrillar material seen in amyloidosis. More about this image found in LIGHT CHAIN DEPOSITION DISEASE: ULTRASTRUCTURE The granular deposits along...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 18
Published: 01 January 2024
10.55418/9781933477367-12
ISBN-10: 1-933477-36-9
ISBN: 978-1-933477-36-7
... , Basili   T , et al . Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors . Nat Commun   2018 ; 9 : 3533 . 26. Röcken   C , Kronsbein   H , Sletten   K , Roessner   A , Bässler   R . Amyloidosis of the breast . Virchows Arch   2002 ; 440 : 527 - 35...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch13
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... sample, no informed consent, etc.) Genetic amyloidosis (A-TTR) or hemochromatosis (HFE) Nongenetic etiologies (M) Myocarditis (V) Viral infection (add the virus identified in affected heart) (AI) Autoimmune/immune-mediated; suspected (AL-S), proven (AI-P) (A) Amyloidosis (add type of amyloidosis: A-K...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch16
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... diagnosis requires exclusion of all known secondary causes of restrictive hemodynamics (e.g., amyloidosis, sarcoidosis, eosinophilic endomyocardial disease, hemochromatosis). The genes involved overlap appreciably with those seen in other forms of cardiomyopathy and include those encoding sarcomeric...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch15
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
...: comparison to athletes and hypertensives . Eur Heart J   1985 ; 6 : 967 - 74 . 67. Maleszewski   JJ . Cardiac amyloidosis: pathology, nomenclature, and typing . Cardiovasc Pathol   2015 ; 24 : 343 - 50 . 68. Goor   D , Lillehei   CW , Edwards   JE . The “sigmoid septum...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch25
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
.... ATRIOVENTRICULAR NODAL CALCIFICATION Figure 25-8 ATRIOVENTRICULAR NODAL CALCIFICATION A large deposit of calcium (yellow arrows) is seen in the region of the AV node in a patient that had clinical atrioventricular block. NODAL AMYLOIDOSIS Figure 25-9 NODAL AMYLOIDOSIS This sulfated Alcian blue stain shows...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch26
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... the increased volume. If the heart itself is no longer compliant (e.g., restrictive cardiomyopathy, amyloidosis) this finding is not present because the heart muscle itself is abnormal. Treatment. The treatment of constrictive pericarditis is pericardiectomy ( 14 , 16 ). A total removal is often not possible...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch51
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... , Edwards   WD , Oh   JK , et al . Intracardiac thrombosis and embolism in patients with cardiac amyloidosis . Circulation   2007 ; 116 : 2420 - 6 . 27. de Winkel   N , Becker   K , Vogt   M . Echogenic mass in the right atrium after surgical ventricular septal defect closure...
Book Chapter

Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch14
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... likelihood of a secondary cause, can be processed with two hematoxylin and eosin (H&E)-stained slides (including 5 step sections, per slide), a tissue iron stain (to exclude hemochromatosis), and a sulfated Alcian blue stain (to assess fibrosis and amyloidosis). A piece may be reserved in glutaraldehyde...