AMYLOID PLAQUES Figure 2-6 AMYLOID PLAQUES A: Typical amyloid plaque in human spongiform encephalopathy. B: Variant Creutzfeldt-Jakob disease shows a plaque in the center of spongiform change (identifiable on a routine hematoxylin and eosin [H&E] stain). (Courtesy of Dr. J. Arango, Universit... More about this image found in AMYLOID PLAQUES A: Typical amyloid plaque in human spongiform encephalopat...

IMMUNOHISTOCHEMISTRY IN VARIANT CREUTZFELD-JAKOB DISEASE Figure 2-7 IMMUNOHISTOCHEMISTRY IN VARIANT CREUTZFELD-JAKOB DISEASE A: Positive amyloid plaque on immunohistochemical staining. (Courtesy of the Armed Forces Institute of Pathology) B: Synaptic pattern of PrP^SC immunohistochemical staining. More about this image found in IMMUNOHISTOCHEMISTRY IN VARIANT CREUTZFELD-JAKOB DISEASE A: Positive amylo...

AMYLOID TUMOR Figure 12-9 AMYLOID TUMOR A: This section from a breast mass is remarkable for the presence of pale eosinophilic amorphous material in the stroma. B: A Congo red stain highlights the amyloid. C: Amyloid demonstrates apple green birefringence with polarized light. More about this image found in AMYLOID TUMOR A: This section from a breast mass is remarkable for the pre...

AMYLOID ANGIOPATHY Figure 6-24 AMYLOID ANGIOPATHY Amyloid typically does not affect the epicardial coronary arteries, but when it does, it usually is nonobstructive (black arrowhead). Within the small vasculature (e.g., vasa vasorum), however, the amyloid deposition may be marked and obstructive ... More about this image found in AMYLOID ANGIOPATHY Amyloid typically does not affect the epicardial corona...

ATRIAL AMYLOID Figure 21-15 ATRIAL AMYLOID Atrial amyloid is frequently AANF (atrial natriuretic factor) type, which has a characteristic fibrillar morphology (arrow) compared with the homogeneous pattern seen with other amyloid types (arrowhead) (ATTR [atrial transthyretin], in this case). More about this image found in ATRIAL AMYLOID Atrial amyloid is frequently AANF (atrial natriuretic facto...

AMYLOIDOSIS: STAINS Figure 21-13 AMYLOIDOSIS: STAINS A: Congo red stains amyloid red, as seen by standard light microscopy (left), exhibiting a characteristic apple-green birefringence when viewed in cross-polarized light (right). Collagen has a white birefringence pattern, not to be confused wit... More about this image found in AMYLOIDOSIS: STAINS A: Congo red stains amyloid red, as seen by standard l...

AMYLOIDOSIS: STAINS Figure 21-13 AMYLOIDOSIS: STAINS A: Congo red stains amyloid red, as seen by standard light microscopy (left), exhibiting a characteristic apple-green birefringence when viewed in cross-polarized light (right). Collagen has a white birefringence pattern, not to be confused wit... More about this image found in AMYLOIDOSIS: STAINS A: Congo red stains amyloid red, as seen by standard l...

AMYLOIDOSIS: ULTRASTRUCTURE Figure 21-17 AMYLOIDOSIS: ULTRASTRUCTURE The amyloid fibrils (asterisk) consist of 7- to 10-nm nonbranching fibrils depositing in the extracellular space. More about this image found in AMYLOIDOSIS: ULTRASTRUCTURE The amyloid fibrils (asterisk) consist of 7- t...

AMYLOIDOSIS Figure 21-11 AMYLOIDOSIS A: Four-chamber view shows thickened ventricular walls with pale mottling (asterisks) in the basal walls and endocardium corresponding to areas with dense amyloid deposition. B: The valvular surfaces have a gristly or stippled character (arrows) in regions wh... More about this image found in AMYLOIDOSIS A: Four-chamber view shows thickened ventricular walls with pa...

AMYLOIDOSIS: GIANT CELL REACTION Figure 21-16 AMYLOIDOSIS: GIANT CELL REACTION Giant cell reaction to interstitial amyloid deposition, the significance of which is unknown. More about this image found in AMYLOIDOSIS: GIANT CELL REACTION Giant cell reaction to interstitial amylo...