PHEOCHROMOCYTOMA Figure 8-24 PHEOCHROMOCYTOMA Spindle cell morphology is also seen in tumors with solid cohesive growth. More about this image found in PHEOCHROMOCYTOMA Spindle cell morphology is also seen in tumors with solid...

COMPLEX OF MYXOMA AND SPOTTY PIGMENTATION Figure 4-22 COMPLEX OF MYXOMA AND SPOTTY PIGMENTATION A: A young girl with multiple pigmented lesions about the mouth. The patient also had a darkly pigmented lesion on the vulva, probably a blue nevus. B: Cutaneous myxoma on the breast of the same patie... More about this image found in COMPLEX OF MYXOMA AND SPOTTY PIGMENTATION A: A young girl with multiple pi...

PRIMARY ADRENAL ANGIOSARCOMA Figure 12-10 PRIMARY ADRENAL ANGIOSARCOMA A: There is well-developed vasoformative architecture with sinusoidal growth between cords of vacuolated cortical cells. Acute inflammatory cells and eosinophils are also present. B: Primary adrenal angiosarcoma (same case as... More about this image found in PRIMARY ADRENAL ANGIOSARCOMA A: There is well-developed vasoformative arch...

CUSHING DISEASE Figure 3-12 CUSHING DISEASE Bilateral adrenal hyperplasia in a patient with ACTH-secreting pituitary tumor. There is mild and micronodular increase in size in the left (A) and right (B) adrenal glands. The right gland also has a macronodule (over 1 cm). More about this image found in CUSHING DISEASE Bilateral adrenal hyperplasia in a patient with ACTH-secre...

GANGLIONEUROBLASTOMA INTERMIXED Figure 11-30 GANGLIONEUROBLASTOMA INTERMIXED Biopsy of paravertebral mass in 11-year-old girl shows areas of schwannian stroma, intermingled with areas of immature stroma containing cells with varying differentiation toward ganglion cells, but also including neurob... More about this image found in GANGLIONEUROBLASTOMA INTERMIXED Biopsy of paravertebral mass in 11-year-ol...

PHEOCHROMOCYTOMA: ⁶⁸GA DOTATATE SCAN Figure 8-51 PHEOCHROMOCYTOMA: ⁶⁸GA DOTATATE SCAN Multifocal osteolytic skeletal lesions demonstrate dotatate avidity consistent with a somatostatin receptor-positive tumor. There is also activity in the retroperitoneum showing recurrent disease around the resection margin of the primary tumor. More about this image found in PHEOCHROMOCYTOMA: ⁶⁸GA DOTATATE SCAN Multifocal osteolytic skel...

NEUROBLASTOMA FOLLOWING CHEMOTHERAPY Figure 11-20 NEUROBLASTOMA FOLLOWING CHEMOTHERAPY This resection specimen showed the typical heterogeneity of neuroblastic tumors with areas of immature cells and stroma (not shown), calcification, but also completely matured areas as shown in this image, with... More about this image found in NEUROBLASTOMA FOLLOWING CHEMOTHERAPY This resection specimen showed the ty...

PHEOCHROMOCYTOMA: SUSTENTACULAR CELLS Figure 8-39 PHEOCHROMOCYTOMA: SUSTENTACULAR CELLS A: Antibodies to S-100 protein show strong nuclear and cytoplasmic positivity in sustentacular cells, identified easily even if the tumor cells also show diffuse reactivity. B: The nuclei of sustentacular cel... More about this image found in PHEOCHROMOCYTOMA: SUSTENTACULAR CELLS A: Antibodies to S-100 protein show ...

ADRENAL CORTICAL CARCINOMA Figure 6-8 ADRENAL CORTICAL CARCINOMA An ACC from a 32-year-old female weighed 2,200 g and measured 21 cm in diameter. There were extensive areas of necrosis with foci of vascular invasion. The patient also had pulmonary metastases at the time of diagnosis. More about this image found in ADRENAL CORTICAL CARCINOMA An ACC from a 32-year-old female weighed 2,200 ...

Ki-67 IN FETAL ADRENAL GLAND Figure 1-15 Ki-67 IN FETAL ADRENAL GLAND Immunoreactivity for Ki-67 is abundant in the definitive zone, which is the major site of cortical cell generation. Scattered individual stained cortical cells are also present in the provisional zone, along with aggregates of ... More about this image found in Ki-67 IN FETAL ADRENAL GLAND Immunoreactivity for Ki-67 is abundant in the...

ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-23 ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Greatly enlarged pleomorphic nuclei are seen in some cells, which are markedly different than the nuclei of adjacent tumor cells. A few cells also contain finely granula... More about this image found in ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Greatly enlarged...

MULTIFOCAL PARAGANGLIOMAS IN SDHX DISEASE Figure 10-1 MULTIFOCAL PARAGANGLIOMAS IN SDHX DISEASE A: This patient, with a documented pathogenic germline SDHB variant, was diagnosed with a right carotid body tumor. B,C: ⁶⁸Ga-DOTATATE PET/CT also showed multiple lesions in his retroperitoneum. (A–C: courtesy of Dr. S. Ezzat, Toronto, Canada) More about this image found in MULTIFOCAL PARAGANGLIOMAS IN SDHX DISEASE A: This patient, with a document...

URINARY BLADDER PARAGANGLIOMA Figure 9-35 URINARY BLADDER PARAGANGLIOMA A: This extensively invasive urinary bladder paraganglioma deep within the bladder wall is a potential mimic of prostatic or urothelial carcinoma. B: Diffuse expression of tyrosine hydroxylase confirms the identity of the tu... More about this image found in URINARY BLADDER PARAGANGLIOMA A: This extensively invasive urinary bladder...

ADRENAL HEPATIC UNION WITH ISOLATED CORTICAL CELL NESTS Figure 2-2 ADRENAL HEPATIC UNION WITH ISOLATED CORTICAL CELL NESTS Heterotopic adrenal cortical tissue is within liver parenchyma, with isolated nests of cortical cells. Intrahepatic adrenal heterotopia was present just beneath the liver cap... More about this image found in ADRENAL HEPATIC UNION WITH ISOLATED CORTICAL CELL NESTS Heterotopic adrena...

BODY AND HEAD OF NORMAL ADRENAL GLAND Figure 1-23 BODY AND HEAD OF NORMAL ADRENAL GLAND In this transverse section, the medullary compartment appears dull gray in contrast to the bright yellow cortex. Partial to complete cuffs of cortex are present around the central adrenal vein and its tributar... More about this image found in BODY AND HEAD OF NORMAL ADRENAL GLAND In this transverse section, the medu...

DIFFERENTIATING NEUROBLASTOMA Figure 11-14 DIFFERENTIATING NEUROBLASTOMA This tumor shows areas of ganglion cell differentiation, which are still in an immature neuropil matrix, flanked by areas of schwannian stroma (upper right), but also by areas of immature neuroblasts (lower left). When there... More about this image found in DIFFERENTIATING NEUROBLASTOMA This tumor shows areas of ganglion cell diff...

PEDIATRIC ADRENAL CORTICAL CARCINOMA Figure 6-42 PEDIATRIC ADRENAL CORTICAL CARCINOMA This tumor showed capsular (A) and vascular invasion (B,C). Increased mitotic activity and rare atypical mitotic figures were also found. Cytologic atypia was mild as it is usually in pediatric adrenal cortical ... More about this image found in PEDIATRIC ADRENAL CORTICAL CARCINOMA This tumor showed capsular (A) and va...

DUODENAL PARAGANGLIOMA Figure 9-33 DUODENAL PARAGANGLIOMA A: This tumor was initially interpreted as an epithelial intestinal NET. However, it was negative for keratins and expressed paraganglioma markers. The absence of keratins also weighed against a diagnosis of composite gangliocytoma/neuroma... More about this image found in DUODENAL PARAGANGLIOMA A: This tumor was initially interpreted as an epith...

INTRACORTICAL LEYDIG CELLS Figure 1-38 INTRACORTICAL LEYDIG CELLS A solitary cluster of Leydig (or hilus) cells with numerous Reinke crystalloids were noted incidentally in the normal part of an adrenal gland removed because of an aldosterone-secreting cortical adenoma. Most of the Leydig cells a... More about this image found in INTRACORTICAL LEYDIG CELLS A solitary cluster of Leydig (or hilus) cells w...

JUVENILE (CAPILLARY) ADRENAL HEMANGIOMA Figure 12-9 JUVENILE (CAPILLARY) ADRENAL HEMANGIOMA A,B: Small juvenile hemangioma of the adrenal gland in a newborn. There were numerous cutaneous hemangiomas and a large vascular tumor of the liver with identical histology. The adrenal tumor is uniformly ... More about this image found in JUVENILE (CAPILLARY) ADRENAL HEMANGIOMA A,B: Small juvenile hemangioma of ...