BLACK ADRENAL CORTICAL ADENOMA Figure 5-14 BLACK ADRENAL CORTICAL ADENOMA A: The adenoma was resected from a 58-year-old man with Cushing syndrome. The dark exterior aspect of the tumor is evident through the intact adrenal capsule and thin investing fat. B: The tumor measured 2.9 x 2.8 x 2.5 cm... More about this image found in BLACK ADRENAL CORTICAL ADENOMA A: The adenoma was resected from a 58-year-...

CORTISOL-SECRETING ADRENAL CORTICAL ADENOMA Figure 5-19 CORTISOL-SECRETING ADRENAL CORTICAL ADENOMA A: This adenoma consists of a homogeneous population of predominantly clear cells with marked atrophy of the adjacent cortex. B: The clear cells have uniform small round nuclei and abundant cytopl... More about this image found in CORTISOL-SECRETING ADRENAL CORTICAL ADENOMA A: This adenoma consists of a ...

ATYPICAL CELLS IN ADRENAL CORTICAL ADENOMA Figure 5-24 ATYPICAL CELLS IN ADRENAL CORTICAL ADENOMA This cortical adenoma exhibits focal “endocrine atypia” and lipomatous change. More about this image found in ATYPICAL CELLS IN ADRENAL CORTICAL ADENOMA This cortical adenoma exhibits ...

“BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-43 “BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME This black adenoma is characterized by a variably pigmented cell population (A), focally dense lymphocytic infiltration and adipose metaplasia (B). More about this image found in “BLACK” ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME This black adenoma is...

ADRENAL CORTICAL ADENOMA, STROMAL CHANGES Figure 5-29 ADRENAL CORTICAL ADENOMA, STROMAL CHANGES Some adenomas show focal or predominant areas with stromal changes, either as loose edematous stroma (A) or as more dense and collagenous depositions embedding small clusters of tumor cells (B). More about this image found in ADRENAL CORTICAL ADENOMA, STROMAL CHANGES Some adenomas show focal or pred...

ADRENAL CORTICAL ADENOMA WITH “BALLOON CELLS” Figure 5-17 ADRENAL CORTICAL ADENOMA WITH “BALLOON CELLS” A: The enlarged “balloon cells” in an adrenal cortical adenoma from a patient with Cushing syndrome have greatly expanded, lipid-rich cytoplasm. Some cells were nearly 10-fold larger than other... More about this image found in ADRENAL CORTICAL ADENOMA WITH “BALLOON CELLS” A: The enlarged “balloon cel...

POST-FINE NEEDLE ASPIRATION BIOPSY INVOLUTIVE CHANGES IN AN INCIDENTAL ADRENAL CORTICAL ADENOMA Figure 5-15 POST-FINE NEEDLE ASPIRATION BIOPSY INVOLUTIVE CHANGES IN AN INCIDENTAL ADRENAL CORTICAL ADENOMA Incidental nonfunctional adrenal cortical adenoma in a 73-year-old man who had gallstones. Fi... More about this image found in POST-FINE NEEDLE ASPIRATION BIOPSY INVOLUTIVE CHANGES IN AN INCIDENTAL ADRE...

ONCOCYTIC ADRENAL CORTICAL ADENOMA Figure 5-12 ONCOCYTIC ADRENAL CORTICAL ADENOMA This nonfunctional oncocytic adrenal cortical adenoma weighed 70 g and was 4 cm in diameter. On cross section, the tumor is uniformly mahogany brown. More about this image found in ONCOCYTIC ADRENAL CORTICAL ADENOMA This nonfunctional oncocytic adrenal co...

NONFUNCTIONAL ADRENAL CORTICAL ADENOMA Figure 5-27 NONFUNCTIONAL ADRENAL CORTICAL ADENOMA A: The central portion of this adenoma shows extensive degeneration and hemorrhage with neovascularization. B: Cavernous channels in the hemorrhagic area have features suggestive of a vascular neoplasm. More about this image found in NONFUNCTIONAL ADRENAL CORTICAL ADENOMA A: The central portion of this aden...

ADRENAL CORTICAL ADENOMA WITH SPINDLE CELL FEATURES Figure 5-22 ADRENAL CORTICAL ADENOMA WITH SPINDLE CELL FEATURES Areas of this adrenal adenoma show an ill-defined spindle cell pattern. More conventional histology was present in other fields. More about this image found in ADRENAL CORTICAL ADENOMA WITH SPINDLE CELL FEATURES Areas of this adrenal ...

CORTICAL ATROPHY IN ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-32 CORTICAL ATROPHY IN ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Cortisol-secreting adrenal cortical adenoma (A, bottom) with atrophic perilesional adrenal cortex (A, top and B). More about this image found in CORTICAL ATROPHY IN ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDRO...

ADRENAL CORTICAL ADENOMA WITH CUSHING SYNDROME Figure 5-7 ADRENAL CORTICAL ADENOMA WITH CUSHING SYNDROME This adrenal cortical adenoma from a 32-year-old woman with Cushing syndrome measured 2.1 cm. The geographic to mottled zones of dark pigmentation are due to lipid depletion of neoplastic cort... More about this image found in ADRENAL CORTICAL ADENOMA WITH CUSHING SYNDROME This adrenal cortical adeno...

ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-8 ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME This adrenal cortical adenoma is from a 33-year-old patient with Cushing syndrome. The tumor is yellow-orange on cross section and has vague lobulations. It measured 3.5 ... More about this image found in ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME This adrenal cor...

ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA Figure 4-27 ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA A: The tumor has expansile smooth borders that compress adjacent adrenal parenchyma and expand the adrenal capsule. B: The borders of the adenoma are sharply demarcated from the adjacent cor... More about this image found in ALDOSTERONE-SECRETING ADRENAL CORTICAL ADENOMA A: The tumor has expansile ...

ADRENAL CORTICAL ADENOMA IN A PATIENT WITH FH GERMLINE MUTATION Figure 7-7 ADRENAL CORTICAL ADENOMA IN A PATIENT WITH FH GERMLINE MUTATION This patient had a previous renal cell carcinoma and a Leydig cell tumor. The adenoma shows a nodular aspect without cytologic atypia or other worrisome cellular or architectural features. Preexistent cortex is present at the top of the image. More about this image found in ADRENAL CORTICAL ADENOMA IN A PATIENT WITH FH GERMLINE MUT...

ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME Figure 5-4 ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME US scan (A), CT scan (B, 20 HU), and magnetic resonance imaging (MRI) (“in” phase, C, and “out” phase, D) show a lipid-poor pattern in a 4.5-cm adenoma. (Courtesy of Prof. A. Veltri and Dr. F. Sol... More about this image found in ADRENAL CORTICAL ADENOMA IN CUSHING SYNDROME US scan (A), CT scan (B, 20 H...

ONCOCYTIC ADRENAL CORTICAL ADENOMA COEXISTING WITH A CLEAR CELL CORTICAL NODULE Figure 5-13 ONCOCYTIC ADRENAL CORTICAL ADENOMA COEXISTING WITH A CLEAR CELL CORTICAL NODULE The dishomogeneous brown nodule, 2.7 cm in size (bottom), corresponded histologically to an oncocytic adenoma, well-circumscr... More about this image found in ONCOCYTIC ADRENAL CORTICAL ADENOMA COEXISTING WITH A CLEAR CELL CORTICAL NO...

ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOMA AND CARCINOMA Figure 5-31 ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOMA AND CARCINOMA A diagnosis of adrenal cortical carcinoma was suspected because of the presence of predominant oncocyti... More about this image found in ANCILLARY STAINING IN THE DIFFERENTIAL DIAGNOSIS OF ADRENAL CORTICAL ADENOM...

ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME Figure 5-9 ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME This adrenal cortical adenoma is from a 35-year-old female with Cushing syndrome. The tumor has a confluent brown color due to cells with compact, lipid-de pleted cytopla... More about this image found in ADRENAL CORTICAL ADENOMA ASSOCIATED WITH CUSHING SYNDROME This adrenal cor...