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adamantinoma
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Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
10.55418/9781933477138-10
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
...Osteofibrous dysplasia is considered a benign fibro-osseous intracortical lesion of long bone, while adamantinoma is defined as a malignant biphasic tumor characterized by epithelial cells, embedded in a fairly bland osteofibrous proliferation. Based on overlapping clinical...
Images
Published: 01 October 2021
OSTEOFIBROUS DYSPLASIA LIKE-ADAMANTINOMA Figure 10-11 OSTEOFIBROUS DYSPLASIA LIKE-ADAMANTINOMA Left: Based on current criteria, the distinction of osteofibrous dysplasia from osteofibrous dysplasia-like adamantinoma is the presence of epithelial nests (clusters of three or more cells). Right: Wh... More about this image found in OSTEOFIBROUS DYSPLASIA LIKE-ADAMANTINOMA Left: Based on current criteria, ...
Images
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-22 CLASSIC ADAMANTINOMA In addition to keratin AE1/AE3, the epithelial cells in adamantinoma are positive for p63 (left) and TLE1 (right). More about this image found in CLASSIC ADAMANTINOMA In addition to keratin AE1/AE3, the epithelial cells ...
Images
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-21 CLASSIC ADAMANTINOMA A,B: Typical biphasic appearance, with tubular differentiation in the epithelial component. C,D: The epithelial component in adamantinoma is positive for cytokeratin 14 (C) and p63 (D). More about this image found in CLASSIC ADAMANTINOMA A,B: Typical biphasic appearance, with tubular differ...
Images
Published: 01 October 2021
OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Figure 10-10 OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Left: Osteoclast-like giant cells in osteofibrous dysplasia-like adamantinoma are close to the woven bone trabeculae. Right: High-power view shows small nests of epithelial cells. More about this image found in OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Left: Osteoclast-like giant cells...
Images
Published: 01 October 2021
OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Figure 10-7 OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA A: Lateral radiograph of the leg in a patient with osteofibrous dysplasia-like adamantinoma shows a lytic lesion in the anterior tibia, which involves the anterior cortex with extension into the medullar... More about this image found in OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA A: Lateral radiograph of the leg ...
Images
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-16 CLASSIC ADAMANTINOMA Large epithelial islands are obvious at low-power magnification. More about this image found in CLASSIC ADAMANTINOMA Large epithelial islands are obvious at low-power mag...
Images
Published: 01 October 2021
OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Figure 10-8 OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA The cortex and medullary cavity are involved by tumor. More about this image found in OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA The cortex and medullary cavity a...
Images
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-17 CLASSIC ADAMANTINOMA Epithelial elements have a tubular appearance (left), and epithelial cells can form interconnecting tubular structures (right). More about this image found in CLASSIC ADAMANTINOMA Epithelial elements have a tubular appearance (left),...
Images
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-20 CLASSIC ADAMANTINOMA Left: There is a basaloid pattern with nuclear palisading, combined with squamous differentiation. Right: Though rare, squamous differentiation can be prominent. More about this image found in CLASSIC ADAMANTINOMA Left: There is a basaloid pattern with nuclear palisa...
Images
Published: 01 October 2021
DEDIFFERENTIATED ADAMANTINOMA Figure 10-24 DEDIFFERENTIATED ADAMANTINOMA Left: Osteoid deposition and clear cell change can be seen. Right: Expression of keratin AE1/AE3 is largely retained in these areas. More about this image found in DEDIFFERENTIATED ADAMANTINOMA Left: Osteoid deposition and clear cell chan...
Images
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-14 CLASSIC ADAMANTINOMA Left: Frontal radiograph of the leg demon strates a cortically based lytic and sclerotic lesion in the distal tibial diaphysis. Right: Resection shows a tan, fleshy intramedullary tumor scalloping the cortices. More about this image found in CLASSIC ADAMANTINOMA Left: Frontal radiograph of the leg demon strates a c...
Images
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-15 CLASSIC ADAMANTINOMA Left: The epithelial component is easily recognized and has a basaloid appearance, with some spindle cell changes. Right: Keratin AE1/AE3 staining highlights epithelial islands of variable size and shape. More about this image found in CLASSIC ADAMANTINOMA Left: The epithelial component is easily recognized a...
Images
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-12 CLASSIC ADAMANTINOMA Left: Frontal radiograph shows a lobulated lytic lesion in the anterior cortex of the tibial diaphysis. Cortical destruction is present (arrow). Above: Axial CT of the lobulated lytic lesion with areas of cortical destruction (arrows). More about this image found in CLASSIC ADAMANTINOMA Left: Frontal radiograph shows a lobulated lytic lesi...
Images
Published: 01 October 2021
DEDIFFERENTIATED ADAMANTINOMA Figure 10-23 DEDIFFERENTIATED ADAMANTINOMA Left: The original characteristic epithelial differentiation is lost, and instead, areas of large pleomorphic epithelioid cells are seen, with a high mitotic rate. Right: Expression of keratin AE1/AE3 is retained in these l... More about this image found in DEDIFFERENTIATED ADAMANTINOMA Left: The original characteristic epithelial...
Images
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-19 CLASSIC ADAMANTINOMA Left: The spindle cells have a herringbone pattern. If the spindle cells predominate, especially in a biopsy specimen, the differential diagnosis is broad and includes synovial sarcoma. Right: Transitional areas are seen toward areas in whic... More about this image found in CLASSIC ADAMANTINOMA Left: The spindle cells have a herringbone pattern. I...
Images
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-18 CLASSIC ADAMANTINOMA Different patterns may be seen within one tumor. In this lesion, a tubular and spindle cell pattern coexist. A: A transition pattern can be seen. B: The spindle cell component is highly cellular and monomorphic, morphologically resembling s... More about this image found in CLASSIC ADAMANTINOMA Different patterns may be seen within one tumor. In t...
Images
Published: 01 October 2021
OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Figure 10-9 OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Left: At low power morphology is very similar to that of osteofibrous dysplasia, with irregular woven bone lined by well-defined osteoblasts in a background of fibrous stroma. Distinction should be made ... More about this image found in OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Left: At low power morphology is ...
Images
Published: 01 October 2021
CLASSIC ADAMANTINOMA WITH AGGRESSIVE FEATURES Figure 10-13 CLASSIC ADAMANTINOMA WITH AGGRESSIVE FEATURES Left: Frontal radiograph of the leg shows a large lytic lesion with cortical and medullary involvement. Cortical destruction is present. Right: The corresponding gross specimen in which the p... More about this image found in CLASSIC ADAMANTINOMA WITH AGGRESSIVE FEATURES Left: Frontal radiograph of ...
Images
Published: 01 October 2021
TIBIAL BONE TUMORS Figure 3-9 TIBIAL BONE TUMORS Adamantinoma (left) and osteofibrous dysplasia (right) (arrows). More about this image found in TIBIAL BONE TUMORS Adamantinoma (left) and osteofibrous dysplasia (right) ...
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