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adamantinoma

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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 8
Published: 01 October 2021
10.55418/9781933477138-10
ISBN-10: 1-933477-13-X
ISBN: 978-1-933477-13-8
...Osteofibrous dysplasia is considered a benign fibro-osseous intracortical lesion of long bone, while adamantinoma is defined as a malignant biphasic tumor characterized by epithelial cells, embedded in a fairly bland osteofibrous proliferation. Based on overlapping clinical...
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OSTEOFIBROUS DYSPLASIA LIKE-<span class="search-highlight">ADAMANTINOMA</span>  Left: Based on current criteria, ...
Published: 01 October 2021
OSTEOFIBROUS DYSPLASIA LIKE-ADAMANTINOMA Figure 10-11 OSTEOFIBROUS DYSPLASIA LIKE-ADAMANTINOMA Left: Based on current criteria, the distinction of osteofibrous dysplasia from osteofibrous dysplasia-like adamantinoma is the presence of epithelial nests (clusters of three or more cells). Right: Wh... More about this image found in OSTEOFIBROUS DYSPLASIA LIKE-ADAMANTINOMA Left: Based on current criteria, ...
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CLASSIC <span class="search-highlight">ADAMANTINOMA</span>  In addition to keratin AE1/AE3, the epithelial cells ...
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-22 CLASSIC ADAMANTINOMA In addition to keratin AE1/AE3, the epithelial cells in adamantinoma are positive for p63 (left) and TLE1 (right). More about this image found in CLASSIC ADAMANTINOMA In addition to keratin AE1/AE3, the epithelial cells ...
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CLASSIC <span class="search-highlight">ADAMANTINOMA</span>  A,B: Typical biphasic appearance, with tubular differ...
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-21 CLASSIC ADAMANTINOMA A,B: Typical biphasic appearance, with tubular differentiation in the epithelial component. C,D: The epithelial component in adamantinoma is positive for cytokeratin 14 (C) and p63 (D). More about this image found in CLASSIC ADAMANTINOMA A,B: Typical biphasic appearance, with tubular differ...
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OSTEOFIBROUS DYSPLASIA-LIKE <span class="search-highlight">ADAMANTINOMA</span>  Left: Osteoclast-like giant cells...
Published: 01 October 2021
OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Figure 10-10 OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Left: Osteoclast-like giant cells in osteofibrous dysplasia-like adamantinoma are close to the woven bone trabeculae. Right: High-power view shows small nests of epithelial cells. More about this image found in OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Left: Osteoclast-like giant cells...
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OSTEOFIBROUS DYSPLASIA-LIKE <span class="search-highlight">ADAMANTINOMA</span>  A: Lateral radiograph of the leg ...
Published: 01 October 2021
OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Figure 10-7 OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA A: Lateral radiograph of the leg in a patient with osteofibrous dysplasia-like adamantinoma shows a lytic lesion in the anterior tibia, which involves the anterior cortex with extension into the medullar... More about this image found in OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA A: Lateral radiograph of the leg ...
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OSTEOFIBROUS DYSPLASIA-LIKE <span class="search-highlight">ADAMANTINOMA</span>  The cortex and medullary cavity a...
Published: 01 October 2021
OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Figure 10-8 OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA The cortex and medullary cavity are involved by tumor. More about this image found in OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA The cortex and medullary cavity a...
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CLASSIC <span class="search-highlight">ADAMANTINOMA</span>  Epithelial elements have a tubular appearance (left),...
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-17 CLASSIC ADAMANTINOMA Epithelial elements have a tubular appearance (left), and epithelial cells can form interconnecting tubular structures (right). More about this image found in CLASSIC ADAMANTINOMA Epithelial elements have a tubular appearance (left),...
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CLASSIC <span class="search-highlight">ADAMANTINOMA</span>  Left: There is a basaloid pattern with nuclear palisa...
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-20 CLASSIC ADAMANTINOMA Left: There is a basaloid pattern with nuclear palisading, combined with squamous differentiation. Right: Though rare, squamous differentiation can be prominent. More about this image found in CLASSIC ADAMANTINOMA Left: There is a basaloid pattern with nuclear palisa...
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DEDIFFERENTIATED <span class="search-highlight">ADAMANTINOMA</span>  Left: Osteoid deposition and clear cell chan...
Published: 01 October 2021
DEDIFFERENTIATED ADAMANTINOMA Figure 10-24 DEDIFFERENTIATED ADAMANTINOMA Left: Osteoid deposition and clear cell change can be seen. Right: Expression of keratin AE1/AE3 is largely retained in these areas. More about this image found in DEDIFFERENTIATED ADAMANTINOMA Left: Osteoid deposition and clear cell chan...
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CLASSIC <span class="search-highlight">ADAMANTINOMA</span>  Left: Frontal radiograph of the leg demon strates a c...
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-14 CLASSIC ADAMANTINOMA Left: Frontal radiograph of the leg demon strates a cortically based lytic and sclerotic lesion in the distal tibial diaphysis. Right: Resection shows a tan, fleshy intramedullary tumor scalloping the cortices. More about this image found in CLASSIC ADAMANTINOMA Left: Frontal radiograph of the leg demon strates a c...
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CLASSIC <span class="search-highlight">ADAMANTINOMA</span>  Left: The epithelial component is easily recognized a...
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-15 CLASSIC ADAMANTINOMA Left: The epithelial component is easily recognized and has a basaloid appearance, with some spindle cell changes. Right: Keratin AE1/AE3 staining highlights epithelial islands of variable size and shape. More about this image found in CLASSIC ADAMANTINOMA Left: The epithelial component is easily recognized a...
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CLASSIC <span class="search-highlight">ADAMANTINOMA</span>  Left: Frontal radiograph shows a lobulated lytic lesi...
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-12 CLASSIC ADAMANTINOMA Left: Frontal radiograph shows a lobulated lytic lesion in the anterior cortex of the tibial diaphysis. Cortical destruction is present (arrow). Above: Axial CT of the lobulated lytic lesion with areas of cortical destruction (arrows). More about this image found in CLASSIC ADAMANTINOMA Left: Frontal radiograph shows a lobulated lytic lesi...
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DEDIFFERENTIATED <span class="search-highlight">ADAMANTINOMA</span>  Left: The original characteristic epithelial...
Published: 01 October 2021
DEDIFFERENTIATED ADAMANTINOMA Figure 10-23 DEDIFFERENTIATED ADAMANTINOMA Left: The original characteristic epithelial differentiation is lost, and instead, areas of large pleomorphic epithelioid cells are seen, with a high mitotic rate. Right: Expression of keratin AE1/AE3 is retained in these l... More about this image found in DEDIFFERENTIATED ADAMANTINOMA Left: The original characteristic epithelial...
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CLASSIC <span class="search-highlight">ADAMANTINOMA</span>  Left: The spindle cells have a herringbone pattern. I...
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-19 CLASSIC ADAMANTINOMA Left: The spindle cells have a herringbone pattern. If the spindle cells predominate, especially in a biopsy specimen, the differential diagnosis is broad and includes synovial sarcoma. Right: Transitional areas are seen toward areas in whic... More about this image found in CLASSIC ADAMANTINOMA Left: The spindle cells have a herringbone pattern. I...
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CLASSIC <span class="search-highlight">ADAMANTINOMA</span>  Different patterns may be seen within one tumor. In t...
Published: 01 October 2021
CLASSIC ADAMANTINOMA Figure 10-18 CLASSIC ADAMANTINOMA Different patterns may be seen within one tumor. In this lesion, a tubular and spindle cell pattern coexist. A: A transition pattern can be seen. B: The spindle cell component is highly cellular and monomorphic, morphologically resembling s... More about this image found in CLASSIC ADAMANTINOMA Different patterns may be seen within one tumor. In t...
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OSTEOFIBROUS DYSPLASIA-LIKE <span class="search-highlight">ADAMANTINOMA</span>  Left: At low power morphology is ...
Published: 01 October 2021
OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Figure 10-9 OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Left: At low power morphology is very similar to that of osteofibrous dysplasia, with irregular woven bone lined by well-defined osteoblasts in a background of fibrous stroma. Distinction should be made ... More about this image found in OSTEOFIBROUS DYSPLASIA-LIKE ADAMANTINOMA Left: At low power morphology is ...
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CLASSIC <span class="search-highlight">ADAMANTINOMA</span> WITH AGGRESSIVE FEATURES  Left: Frontal radiograph of ...
Published: 01 October 2021
CLASSIC ADAMANTINOMA WITH AGGRESSIVE FEATURES Figure 10-13 CLASSIC ADAMANTINOMA WITH AGGRESSIVE FEATURES Left: Frontal radiograph of the leg shows a large lytic lesion with cortical and medullary involvement. Cortical destruction is present. Right: The corresponding gross specimen in which the p... More about this image found in CLASSIC ADAMANTINOMA WITH AGGRESSIVE FEATURES Left: Frontal radiograph of ...
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