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Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in an angled fashion. In contrast to these nevus-associated patterns, acral melanoma tends to display a parallel ridge pattern and other melanoma-associated dermoscopic features, such as diffuse irregular pigmentation, peripheral dots/globules, abrupt edge, or a blue-gray veil. Microscopic Findings. Features...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of nests and fascicles. The cell density is generally higher and maturation is less developed or absent, with tumors often displaying compact solid growth with an abrupt interface with the dermis. The base of the lesion may display a bulbous growth pattern ( fig. 7-23 ). ATYPICAL SPITZ TUMOR Figure 7-22...
Images
VALVULAR INJURY  An elastic stain highlights loss of the valvular fibrosa (...
Published: 15 November 2023
VALVULAR INJURY Figure 12-9 VALVULAR INJURY An elastic stain highlights loss of the valvular fibrosa (atrialis), replaced by surface fibrin (white asterisk) and abrupt loss of the valvular elastica (white arrow). More about this image found in VALVULAR INJURY An elastic stain highlights loss of the valvular fibrosa (...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch12
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... ENDOCARDITIS Figure 12-8 NATIVE VALVE ENDOCARDITIS The vegetations consist of fibrin and neutrophilic inflammation. VALVULAR INJURY Figure 12-9 VALVULAR INJURY An elastic stain highlights loss of the valvular fibrosa (atrialis), replaced by surface fibrin (white asterisk) and abrupt loss of the valvular...
Images
MICROPAPILLARY SEROUS BORDERLINE TUMOR  A: There is an <span class="search-highlight">abrupt</span> transition fr...
Published: 01 August 2023
MICROPAPILLARY SEROUS BORDERLINE TUMOR Figure 4-10 MICROPAPILLARY SEROUS BORDERLINE TUMOR A: There is an abrupt transition from larger papillae to micropapillary projections. B: Micropapillary growth occur amid blunt papillae. C: The abrupt transition gives these papillae the appearance of a “m... More about this image found in MICROPAPILLARY SEROUS BORDERLINE TUMOR A: There is an abrupt transition fr...
Images
SEROUS TUBAL INTRAEPITHELIAL CARCINOMA (STIC)  A: Severe nuclear atypia, hi...
Published: 01 August 2023
SEROUS TUBAL INTRAEPITHELIAL CARCINOMA (STIC) Figure 16-10 SEROUS TUBAL INTRAEPITHELIAL CARCINOMA (STIC) A: Severe nuclear atypia, high N:C ratios, cell budding and detachment. B: Nuclear enlargement, high N:C ratios, a mitotic figure and an incipient micropapilla at lower right. Non-neoplastic ... More about this image found in SEROUS TUBAL INTRAEPITHELIAL CARCINOMA (STIC) A: Severe nuclear atypia, hi...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-04
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... ( 11 , 12 ). Terminology implying that these are “in situ carcinomas” is currently not recommended ( 3 , 4 ). MICROPAPILLARY SEROUS BORDERLINE TUMOR Figure 4-10 MICROPAPILLARY SEROUS BORDERLINE TUMOR A: There is an abrupt transition from larger papillae to micropapillary projections. B...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-05
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... positivity and mutant pattern staining for p53). The presence of malignant stroma component, with an abrupt transition between the epithelial and stromal components, establishes a diagnosis of carcinosarcoma, even when the sarcomatous component is minor. CARCINOSARCOMA Figure 5-17 CARCINOSARCOMA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-14
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... component is present the interface is usually abrupt, giving the tumor a biphasic appearance. The proportion of differentiated and undifferentiated components can vary greatly. The differentiated component is most commonly endometrioid and rarely serous. Immunohistochemical Findings. Undifferentiated areas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-16
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... at the bottom for comparison. C: Nuclear pleomorphism, severe atypia, ragged luminal border. D: Micropapillary arrangements of highly atypical cells with high N:C ratios. Note abrupt transition to ciliated epithelium at lower left. E: Disordered surface proliferation of malignant cells with budding, cell...
Images
DUCTAL ADENOCARCINOMA  Cancerization of a preexisting duct. Note the adjace...
Published: 01 March 2023
DUCTAL ADENOCARCINOMA Figure 7-12 DUCTAL ADENOCARCINOMA Cancerization of a preexisting duct. Note the adjacent invasive carcinoma (left, arrows) and the abrupt transition from normal epithelium (right, top) to neoplastic epithelium with significant dysplasia (right). More about this image found in DUCTAL ADENOCARCINOMA Cancerization of a preexisting duct. Note the adjace...
Images
VULVAR INTRAEPITHELIAL NEOPLASIA, HPV INDEPENDENT, DIFFERENTIATED TYPE (dVI...
Published: 01 February 2023
VULVAR INTRAEPITHELIAL NEOPLASIA, HPV INDEPENDENT, DIFFERENTIATED TYPE (dVIN) Figure 5-19 VULVAR INTRAEPITHELIAL NEOPLASIA, HPV INDEPENDENT, DIFFERENTIATED TYPE (dVIN) Some examples show marked acanthosis (A). Careful examination at high-power magnification reveals the presence of significant nuc... More about this image found in VULVAR INTRAEPITHELIAL NEOPLASIA, HPV INDEPENDENT, DIFFERENTIATED TYPE (dVI...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... DUCTAL ADENOCARCINOMA Intense desmoplastic reaction to the invasive carcinoma. The neoplastic glands have a haphazard distribution. DUCTAL ADENOCARCINOMA Figure 7-12 DUCTAL ADENOCARCINOMA Cancerization of a preexisting duct. Note the adjacent invasive carcinoma (left, arrows) and the abrupt...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-05
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... of the associated invasive carcinoma and the frequent abrupt transition from completely bland epithelium to epithelium with significant dysplasia ( figs. 5-10 ; 5-18 , right) dictate that MCNs have to be entirely resected and extensively (if not completely) sampled for histologic examination before an invasive...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-5
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... aspect). Abnormal maturation is also characteristic, seen in the form of abrupt keratinization of parabasal cells and individual dyskeratotic cells in the mid-layer (F). At low magnification, the basal cell nuclei are prominent, and closer examination reveals differences in size, prominent nucleoli, open...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 14
Published: 01 February 2023
10.55418/9781933477268-3
ISBN-10: 1-933477-26-1
ISBN: 978-1-933477-26-8
... is predominantly or entirely spindled, the differential diagnosis may also include malignant peripheral nerve sheath tumor (MPNST), NTRK-rearranged sarcoma, and leiomyosarcoma. Histologic features that are more suggestive of MPNST include variably cellular areas with abrupt transition from...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 13
Published: 01 November 2022
10.55418/9781933477251-3
ISBN-10: 1-933477-25-3
ISBN: 978-1-933477-25-1
... carcinoma. In cases with marked nuclear clearing and atypia, a useful clue to distinguish thyroiditis from papillary carcinoma is the gradual transition from atypical areas (most prominent in the areas of active inflammation) to bland follicular cells, which contrast to the abrupt transition in cases...
Images
MESOTHELIAL HYPERPLASIA IN A CHRONIC HYDROCELE  Left: The fibrotically thic...
Published: 01 August 2022
MESOTHELIAL HYPERPLASIA IN A CHRONIC HYDROCELE Figure 11-45 MESOTHELIAL HYPERPLASIA IN A CHRONIC HYDROCELE Left: The fibrotically thickened wall of a chronic hydrocele contains a band of entrapped, hyperplastic mesothelium. Granulation tissue is superficial (right) to the mesothelium. Right: The... More about this image found in MESOTHELIAL HYPERPLASIA IN A CHRONIC HYDROCELE Left: The fibrotically thic...
Images
POSTCHEMOTHERAPY SARCOMATOID YOLK SAC TUMOR  A: The cut surface is white-gr...
Published: 01 August 2022
POSTCHEMOTHERAPY SARCOMATOID YOLK SAC TUMOR Figure 4-240 POSTCHEMOTHERAPY SARCOMATOID YOLK SAC TUMOR A: The cut surface is white-gray to tan with minor cystic foci and a small region of necrosis. B: Multinodular growth is apparent. C: In this high-grade tumor, there is abrupt transition from ce... More about this image found in POSTCHEMOTHERAPY SARCOMATOID YOLK SAC TUMOR A: The cut surface is white-gr...
Images
YOLK SAC TUMOR, POSTPUBERTAL TYPE  A: This tumor shows prominent spindle ce...
Published: 01 August 2022
YOLK SAC TUMOR, POSTPUBERTAL TYPE Figure 4-125 YOLK SAC TUMOR, POSTPUBERTAL TYPE A: This tumor shows prominent spindle cells between alveolar-like glands. B: In other areas of tumor A, there is predominant spindle cell growth with small foci of reticular pattern tumor. C: An untreated sarcomato... More about this image found in YOLK SAC TUMOR, POSTPUBERTAL TYPE A: This tumor shows prominent spindle ce...