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ABDOMINAL PARAGANGLIOMA  A: The tumor, from a patient with a hereditary mut...
Published: 01 December 2024
ABDOMINAL PARAGANGLIOMA Figure 9-13 ABDOMINAL PARAGANGLIOMA A: The tumor, from a patient with a hereditary mutation of the SDHB gene (same specimen as in fig. 9-11 ), has mixed nested and trabecular architecture and is composed of monomorphic cells with slightly eosinophilic cytoplasm. This appearance is often associated with SDHB mutation. B: The strong, diffuse expression of synaptophysin highlights a mixed pattern of nested, trabecular, and diffuse histoarchitecture. C: Immunohistochemical stain for tyrosine hydroxylase shows intratumoral heterogeneity at the functional level, with abrupt transition from strong, diffuse expression to absent expression in a small region of the tumor. D: Immunohistochemical stain for S-100 protein shows heterogeneous distribution of sustentacular cells in adjacent areas of tumor. E: Immunohistochemical stain for glial fibrillary acidic protein (GFAP) shows a small focus of GFAP-positive sustentacular cells in a tumor in which S-100 protein-positive cells were much more numerous. More about this image found in ABDOMINAL PARAGANGLIOMA A: The tumor, from a patient with a hereditary mut...
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CAROTID BODY PARAGANGLIOMA  A: Tumor tissue in most parts of the tumor (sam...
Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA Figure 9-15 CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (same specimen as fig. 9-12 ) shows uniform round nests of weakly eosinophilic cells and cavernous blood vessels. B: This section, taken at the interface between the circumscribed fleshy... More about this image found in CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (sam...
Images
CAROTID BODY PARAGANGLIOMA  A: Tumor tissue in most parts of the tumor (sam...
Published: 01 December 2024
CAROTID BODY PARAGANGLIOMA Figure 9-15 CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (same specimen as fig. 9-12 ) shows uniform round nests of weakly eosinophilic cells and cavernous blood vessels. B: This section, taken at the interface between the circumscribed fleshy... More about this image found in CAROTID BODY PARAGANGLIOMA A: Tumor tissue in most parts of the tumor (sam...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 21
Published: 01 December 2024
10.55418/9781933477473-09
ISBN-10: 1-933477-47-4
ISBN: 978-1-933477-47-3
... mutation. B: The strong, diffuse expression of synaptophysin highlights a mixed pattern of nested, trabecular, and diffuse histoarchitecture. C: Immunohistochemical stain for tyrosine hydroxylase shows intratumoral heterogeneity at the functional level, with abrupt transition from strong, diffuse...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-04
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
..., although not all infections are symptomatic. The severity of symptoms depends on numerous virus factors and the host immune status. Typical symptoms, present in approximately 50 percent of infected individuals, include chills and abrupt onset of high fever, generalized malaise, body aches (myalgia), sore...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 20
Published: 01 September 2024
10.55418/9781933477435-03
ISBN-10: 1-933477-43-1
ISBN: 978-1-933477-43-5
... features, poliomyelitis-like paralysis, or mental illness Cognitive, neurologic or psychiatric sequelae Fatality: 20-30% SLEV >95% 5-15 days Abrupt onset of headache, dizziness, malaise, nausea, and fever Meningitis with confusion, dizziness, disorientation, stiff neck, tremors, and unsteady...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-05
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... in an angled fashion. In contrast to these nevus-associated patterns, acral melanoma tends to display a parallel ridge pattern and other melanoma-associated dermoscopic features, such as diffuse irregular pigmentation, peripheral dots/globules, abrupt edge, or a blue-gray veil. Microscopic Findings. Features...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 19
Published: 01 February 2024
10.55418/9781933477428-07
ISBN-10: 1-933477-42-3
ISBN: 978-1-933477-42-8
... of nests and fascicles. The cell density is generally higher and maturation is less developed or absent, with tumors often displaying compact solid growth with an abrupt interface with the dermis. The base of the lesion may display a bulbous growth pattern ( fig. 7-23 ). ATYPICAL SPITZ TUMOR Figure 7-22...
Images
VALVULAR INJURY  An elastic stain highlights loss of the valvular fibrosa (...
Published: 15 November 2023
VALVULAR INJURY Figure 12-9 VALVULAR INJURY An elastic stain highlights loss of the valvular fibrosa (atrialis), replaced by surface fibrin (white asterisk) and abrupt loss of the valvular elastica (white arrow). More about this image found in VALVULAR INJURY An elastic stain highlights loss of the valvular fibrosa (...
Images
MICROPAPILLARY SEROUS BORDERLINE TUMOR  A: There is an <span class="search-highlight">abrupt</span> transition fr...
Published: 01 August 2023
MICROPAPILLARY SEROUS BORDERLINE TUMOR Figure 4-10 MICROPAPILLARY SEROUS BORDERLINE TUMOR A: There is an abrupt transition from larger papillae to micropapillary projections. B: Micropapillary growth occur amid blunt papillae. C: The abrupt transition gives these papillae the appearance of a “m... More about this image found in MICROPAPILLARY SEROUS BORDERLINE TUMOR A: There is an abrupt transition fr...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 17
Published: 15 November 2023
10.55418/9781933477299-ch12
ISBN-10: 1-933477-29-6
ISBN: 978-1-933477-29-9
... ENDOCARDITIS Figure 12-8 NATIVE VALVE ENDOCARDITIS The vegetations consist of fibrin and neutrophilic inflammation. VALVULAR INJURY Figure 12-9 VALVULAR INJURY An elastic stain highlights loss of the valvular fibrosa (atrialis), replaced by surface fibrin (white asterisk) and abrupt loss of the valvular...
Images
SEROUS TUBAL INTRAEPITHELIAL CARCINOMA (STIC)  A: Severe nuclear atypia, hi...
Published: 01 August 2023
SEROUS TUBAL INTRAEPITHELIAL CARCINOMA (STIC) Figure 16-10 SEROUS TUBAL INTRAEPITHELIAL CARCINOMA (STIC) A: Severe nuclear atypia, high N:C ratios, cell budding and detachment. B: Nuclear enlargement, high N:C ratios, a mitotic figure and an incipient micropapilla at lower right. Non-neoplastic ... More about this image found in SEROUS TUBAL INTRAEPITHELIAL CARCINOMA (STIC) A: Severe nuclear atypia, hi...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-04
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... ( 11 , 12 ). Terminology implying that these are “in situ carcinomas” is currently not recommended ( 3 , 4 ). MICROPAPILLARY SEROUS BORDERLINE TUMOR Figure 4-10 MICROPAPILLARY SEROUS BORDERLINE TUMOR A: There is an abrupt transition from larger papillae to micropapillary projections. B...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-05
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... positivity and mutant pattern staining for p53). The presence of malignant stroma component, with an abrupt transition between the epithelial and stromal components, establishes a diagnosis of carcinosarcoma, even when the sarcomatous component is minor. CARCINOSARCOMA Figure 5-17 CARCINOSARCOMA...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-14
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... component is present the interface is usually abrupt, giving the tumor a biphasic appearance. The proportion of differentiated and undifferentiated components can vary greatly. The differentiated component is most commonly endometrioid and rarely serous. Immunohistochemical Findings. Undifferentiated areas...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 16
Published: 01 August 2023
10.55418/9781933477282-16
ISBN-10: 1-933477-28-8
ISBN: 978-1-933477-28-2
... at the bottom for comparison. C: Nuclear pleomorphism, severe atypia, ragged luminal border. D: Micropapillary arrangements of highly atypical cells with high N:C ratios. Note abrupt transition to ciliated epithelium at lower left. E: Disordered surface proliferation of malignant cells with budding, cell...
Images
DUCTAL ADENOCARCINOMA  Cancerization of a preexisting duct. Note the adjace...
Published: 01 March 2023
DUCTAL ADENOCARCINOMA Figure 7-12 DUCTAL ADENOCARCINOMA Cancerization of a preexisting duct. Note the adjacent invasive carcinoma (left, arrows) and the abrupt transition from normal epithelium (right, top) to neoplastic epithelium with significant dysplasia (right). More about this image found in DUCTAL ADENOCARCINOMA Cancerization of a preexisting duct. Note the adjace...
Images
VULVAR INTRAEPITHELIAL NEOPLASIA, HPV INDEPENDENT, DIFFERENTIATED TYPE (dVI...
Published: 01 February 2023
VULVAR INTRAEPITHELIAL NEOPLASIA, HPV INDEPENDENT, DIFFERENTIATED TYPE (dVIN) Figure 5-19 VULVAR INTRAEPITHELIAL NEOPLASIA, HPV INDEPENDENT, DIFFERENTIATED TYPE (dVIN) Some examples show marked acanthosis (A). Careful examination at high-power magnification reveals the presence of significant nuc... More about this image found in VULVAR INTRAEPITHELIAL NEOPLASIA, HPV INDEPENDENT, DIFFERENTIATED TYPE (dVI...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-07
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... DUCTAL ADENOCARCINOMA Intense desmoplastic reaction to the invasive carcinoma. The neoplastic glands have a haphazard distribution. DUCTAL ADENOCARCINOMA Figure 7-12 DUCTAL ADENOCARCINOMA Cancerization of a preexisting duct. Note the adjacent invasive carcinoma (left, arrows) and the abrupt...
Book Chapter
Series: Atlases of Tumor and Non-Tumor Pathology, Series 5
Volume: 15
Published: 01 March 2023
10.55418/9781933477275-05
ISBN-10: 1-933477-27-X
ISBN: 978-1-933477-27-5
... of the associated invasive carcinoma and the frequent abrupt transition from completely bland epithelium to epithelium with significant dysplasia ( figs. 5-10 ; 5-18 , right) dictate that MCNs have to be entirely resected and extensively (if not completely) sampled for histologic examination before an invasive...