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Guide to Series 5 AFIP Atlases of Tumor and Non-Tumor Pathology


Coming Soon

Fascicle 20: Surgical Pathology of Infectious Diseases

By Tomas Slavik, MD; Jeannette Guarner, MD; Alejandro Velez Hoyos, MD

Fascicle 21: Tumors of the Adrenal Glands and Extra-Adrenal Paraganglia

By Ronald deKrijger, MD, PhD; Arthur Tischler, MD; Ernest Lack, MD; Marco Volante, MD, PhD; Sylvia L. Asa, MD, PhD


Published Titles and Summaries

Fascicle 1: Tumors of the Pituitary Gland

By Sylvia L. Asa, MD, PhD; Arie Perry, MD

This book has built on the work that was presented in the previous Fascicles of the Third and Fourth Series. The authors' vast experience has led to new understanding of many aspects of pituitary pathology. With modern immunostaining and molecular techniques, classification of pituitary disease is becoming easier. Furthermore, the availability of targeted therapies has augmented the role of the pathologist in determining an accurate diagnosis. This updated volume addresses modern techniques and their application to treatment of pituitary neoplasms but retains the detailed foundation of morphology in a lushly illustrated tome, the cornerstone of the AFIP fascicles.

Fascicle 2: Tumors of the Prostate Gland, Seminal Vesicles, Penis, and Scrotum

By Jonathan I. Epstein, MD; Cristina Magi-Galluzzi, MD, PhD; Ming Zhou, MD, PhD; Antonio L. Cubilla, MD

Since the last edition of the Tumors of Prostate Gland, Seminal Vesicles, Penis, and Scrotum, there have been numerous significant developments in the diagnosis and treatment of prostate and penile cancers. The new Fifth Series Fascicle of the AFIP Atlas of Tumor Pathology includes these developments as well as abundant images and diagrams to depict the morphological spectrum of disease entities. In this richly illustrated volume, the authors emphasize the gross and microscopic features of neoplastic lesions of these sites, in addition to in depth discussions of immunohistochemical and molecular characteristics, particularly as they relate to treatment and prognosis.

Fascicle 3: Tumors of the Eye and Ocular Adnexa

By Robert Folberg, MD; Patricia Chévez-Barrios, MD; Amy Y. Lin, MD; Tatyana Milman, MD

There have been numerous significant developments in the diagnosis and treatment of ophthalmic tumors since the last edition of the Tumors of the Eye and Ocular Adnexa. This fascicle in the Fifth Series of the AFIP Atlases of Tumor and Non-tumor Pathology includes these developments as well as abundant images to depict ophthalmic pathology. In this richly illustrated volume, the authors emphasize that the pathology of ophthalmic tumors must address not only how to make a correct diagnosis, but also how to guide the ophthalmic surgeon to a treatment plan for the disease while simultaneously preserving a patient's vision.

Fascicle 4: Non-Neoplastic Disorders of the Gastrointestinal Tract

By Rhonda K. Yantiss, MD; Nicole C. Panarelli, MD; Laura W. Lamps, MD

Pathologists play a particularly important role in the care of patients with persistent gastrointestinal symptoms, especially those who are immunosuppressed, suffer from immune-mediated conditions, or undergo treatment for malignancies. They must be able to focus on key features present in biopsy material in order to narrow the differential diagnosis and facilitate patient management. This atlas addresses these needs in a succinct and pragmatic fashion. It describes practical approaches to the diagnosis of inflammatory gastrointestinal disorders and provides helpful criteria to distinguish between newly recognized causes of esophagitis and gastritis.

Fascicle 5: Tumors of the Salivary Glands

By Justin A. Bishop, MD; Lester D. R. Thompson, MD; Paul E. Wakely, Jr., MD; Ilan Weinreb, MD, FRCPC

This book serves as a one-stop, comprehensive reference for the pathology of salivary gland neoplasms, with an emphasis on numerous high-quality, illustrative photomicrographs. The authors incorporated the most cutting-edge genetic data emerging on such tumors, as this information often has a profound impact on their diagnosis and classification. With the quickly evolving nature of salivary gland pathology, this contribution to the Fifth Series is a key update to the previous edition from the Fourth Series, which was published in 2008.

Fascicle 6: Atlas of Placental Pathology

By Drucilla J. Roberts, MD; Carolyn Polizzano, MHS, PA

The placenta is an organ often neglected by surgical pathologists and clinicians alike. Placental diagnoses provide risk assessment for infant prognosis, recurrent risk for future pregnancies, and explanatory findings. There is widespread interest in placental diagnosis for the antenatal determinants of adult disease, inborn errors of metabolism, specific infections, malignancies, and assessing placental function in real time with the ultimate goal of affecting treatment. Due to the difficulties inherent in studying human gestation and gestational pathologies, much of what is known about the relevance of placental pathology is biased toward personal experience and retrospective studies. However, this book presents evidence-based information to the reader. The authors emphasize the need for an educated and directed sampling of the placenta thorough gross examination which will result in a better and more useful final diagnosis.

Fascicle 7: Atlas of Nonmelanocytic Tumors of the Skin

By Thomas Brenn, MD, PhD, FRCPath; John Goodlad, MBChB, MD, FRCPath; Thomas Mentzel, MD

This latest version of the Atlas of Non-melanocytic Tumors of the Skin is rich in illustrations, aimed to highlight important diagnostic aspects of individual cutaneous epithelial, mesenchymal, hematopoietic and lymphoid tumors, and to delineate their morphologic spectrum. The images are supplemented by concise text to emphasize the salient clinical and histologic features, differential diagnosis, and the use of immunohistochemistry and other ancillary tests. The goal is to provide a practical diagnostic guide that will serve as a useful resource for dermatopathology and surgical pathology practice.

Fascicle 8: Tumors of the Bones and Joints

By Gunnlaugur Pétur Nielsen, MD; Andrew E. Rosenberg, MD; Judith VMG Bovée, MD, PhD; Miriam Bredella, MD; Judith A. Ferry, MD

This comprehensive volume includes chapters on bone growth and development, bone tumor imaging, molecular genetics, and all classes of bone and joint tumors. This Fascicle is designed for residents, fellows, and practicing physicians in fields that treat and study patients with bone tumors, including pathology, orthopedics, radiology, medical oncology, and radiation oncology. Along with a wide range of superb illustrations, the authors’ discussions integrate their experience, recent molecular data, and updated information from the World Health Organization Classification of Tumors of Soft Tissue and Bone.

Fascicle 9: Tumors of the Kidney, Bladder, and Related Urinary Structures

By John Eble, MD, MBA, FRCPA, FRCPath; Pedram Argani, MD; David J. Grignon, MD, FRCP(C); Liang Cheng, MD

The evolution of the classification of neoplasms of the urinary passages has changed greatly since Friedman and Ash published the first series AFIP fascicle on the urinary bladder in 1959. In their classification, there were four variants of urothelial neoplasia, some adenomas, adenocarcinoma, and smooth muscle and lymphoid tumors. Today the classification continues to accrue entities based upon morphology, immunophenotype, and compelling clinical associations. The classification of renal cell carcinomas has undergone a profound transformation, with the emergence of many new entities, often with characteristic genetic alterations, with significant implications for prognosis and treatment. This comprehensive, detailed, and lushly illustrated fascicle is a remarkable resource to surgical pathologists and other specialists who treat patients with tumors of these sites.

Fascicle 10: Non-Neoplastic Diseases of the Liver

By Michael S. Torbenson, MD; Sanjay Kakar, MD; Kay Washington, MD, PhD

The primary goal of this fascicle is to be a practical reference for pathologists who review liver biopsies, a most challenging area of diagnostic surgical pathology. It is focused on diagnostic histopathology, discussing and lavishly illustrating disease patterns with an emphasis on differential diagnosis. The key aspects of clinical features, laboratory findings, and pathophysiology are woven into this book. The application and interpretation of special stains and immunohistochemistry are integrated into discussions of each disease pattern.

Fascicle 11: Tumors of the Serosal Membranes

By Andrew G. Nicholson, DM, FRCPath; Aliya N. Husain, MD; Alain C. Borczuk, MD

Since the 4th Series of this Fascicle was published, there have been considerable advances in our understanding of tumors within the serosal membranes, in partic­ular the classification of mesothelial tumors and their genetics. This 5th Series Fascicle aligns with the terminology recommended by the WHO in its most recent edition for pleural and pericardial tumors, with expansion to reflect serosal membranes at other sites and including recognition of mesothelioma in situ.

Fascicle 12: Tumors and Tumor-Like Lesions of the Testis and Adjacent Tissues

By Thomas M. Ulbright, MD; Chia-Sui Kao, MD; Sean R. Williamson, MD; Muhammad T. Idrees, MD

How does a pathologist become interested and develop expertise in testicular and paratesticular neoplasms, which are relatively uncommon? The truth is simple—the opportunity to see many cases. The authors of this 5th Series Fascicle have such expertise and share a remarkable range of cases from their institutions as well as from many pathologists in the United States and throughout the world who have sent them cases in consultation over the years. This fascicle is rich source of material that will be a great resource for practicing pathologists and pathologists in training.

Fascicle 13: Non-Neoplastic Disorders of the Endocrine System

By Anthony Gill, AM, MD, FRCPA; Lori Erickson, MD; Talia Fuchs, MD, FRCPA

In endocrine pathology, surgical pathologists often concentrate on neoplasms at the expense of non-neoplastic disease processes. This is unfortunate as non-neoplastic endocrine disorders are many times more common in the population. As in all fields of medicine, non-neo­plastic endocrine diseases can closely mimic the neoplastic; an awareness of all aspects of pathology underpins routine clinical practice. This 5th Series Fascicle offers pathologists and clinicians an opportunity to develop an increased understanding of nontumor endocrine pathology in order to inform patient care.

Fascicle 14: Tumors of the Cervix, Vagina, and Vulva

By Marisa Nucci, MD; Brooke Howitt, MD; Carlos Parra-Herran, MD; Christopher Crum, MD

The classification and characteristics of tumors and tumor-like lesions of the female lower genital tract have remained relatively constant over the years, though shifts in nomenclature have occurred, and a comprehensive review of the diverse histomorphology and differential diagnosis of lesions at these sites is of paramount importance. Although female lower genital tract pathology is largely dominated by epithelial tumors, the pathologist will also encounter mesenchymal, melanocytic, and hematopoietic neoplasms. This fascicle provides a comprehensive discussion of these categories with emphasis on their widening clinical and pathologic spectrum as well as their evolving molecular landscape. The book conveys the authors’ extensive experience as pathologists devoted to women’s health and to advancing understanding of gynecologic disease.

Fascicle 15: Tumors of the Pancreas

By David Klimstra, MD; Ralph Hruban, MD; Carlie Sigel, MD; Günter Klöppel, MD

While classification of pancreatic neoplasms has not evolved significantly since 2007, data related to the molecular underpinnings that characterize each type of neoplasm have grown exponentially in the past 15 years. The current multimodal study of pancreatic neoplasms has allowed a better understanding of tumor biology, more closely linking the morphologic findings with clinical outcomes and targeted treatment. The prognosis of conventional pancreatic ductal adenocarcinoma remains very poor, but some promise is on the horizon based on novel treatment approaches and the increase in earlier diagnosis. Furthermore, intensive study of other pancreatic neoplasms has led to a clearer recognition that each type has distinctive biology and behavior that is often not so highly aggressive. This sense of optimism may help drive a resurgence of interest in pancreatic pathology.

Fascicle 16: Tumors of the Ovary and Fallopian Tube

By Joseph W. Carlson, MD, PhD; C. Blake Gilks, MD, FRCPC; Robert A. Soslow, MD

The complexity of ovary and fallopian tube pathology is striking, with dozens of tumor types. There is a greater appreciation now of the importance of hereditary cancer syndromes in ovarian and tubal malignancies, as two common autosomal dominant hereditary cancer predisposition syndromes include carcinomas of ovary or fallopian tube. This book is organized following the structure and terminology of the World Health Organization (WHO) classification of Female Genital Tumors, 5th edition. It includes some new entities that have been described since that book’s publication in 2020 and provides detailed discussion of differential diagnosis, relevant ancillary tests, and strategies to approach diagnosis. In addition, discussions of the underlying biology of these tumors, as it relates to their diagnosis, are also presented. This fascicle provides an opportunity for deeper reading and quiet reflection about the progress that has been made in our understanding of tumors of the ovary since the previous landmark edition was published in 1998, as well as a respect for the numerous challenges that remain.

Fascicle 17: Disorders of the Heart and Great Vessels

By Joseph Maleszewski, MD; Allen P. Burke, MD; John P. Veinot, MD; William D. Edwards, MD

This new volume on the heart and great vessels has been expanded to become a comprehensive atlas of all cardiovascular disease—both neoplastic and non-neoplastic. In the spirit of prior editions, correlation of expertly curated pathology photographs and photomicrographs with clinical presentation, imaging and molecular genetics remains the cornerstone. The spectrum of cardiovascular disease, both congenital and acquired, is vast; accounting for the relative size of this fascicle. Every attempt has been made to focus on the clinically-relevant features of the diseases helping not only pathologists, but also providing cardiologists, radiologists, and surgeons a reference to understand the pathologic basis of the conditions they diagnose and treat each day. The authors have meticulously provided gross photographs that mirror (where possible) planar imaging techniques that will enable pathologic-radiologic correlation and facilitate a multidisciplinary approach to patient care.

Fascicle 18: Tumors of the Mammary Gland

By Laura C. Collins, MD

Much has changed in the detection, diagnosis, and management of breast diseases since the previous editions of this fascicle, in particular for patients with invasive breast carcinoma. This 5th series edition conveys the challenges and the joys of diagnostic breast pathology, as well as excitement about the advances that have been, and have yet to be, made in the field.

Fascicle 19: Melanocytic Tumors of Skin

By Klaus Busam, MD; Richard A. Scolyer, MD

This atlas was written for general pathologists, dermatopathologists, and pathologists in training with an interest in practical diagnostic issues in the pathology of melanocytic tumors. The focus of this fascicle is on microscopic clues for diagnosis, in particular for the distinction of melanocytic nevi from melanoma. The authors also discuss the role of ancillary methods and their potential value as well as limitations in test sensitivity and specificity. This volume will help pathologists provide the most accurate diagnoses in service of their clinical care teams and their patients.

Looking Ahead

  • Non-Neoplastic Disorders of Bone and Joints
  • Non-Neoplastic Disorders of the Bone Marrow
  • Non-Neoplastic Disorders of the Kidney
  • Non-Neoplastic Disorders of the Lymph Nodes and Spleen
  • Non-Neoplastic Disorders of Lung, Mediastinum, and Serous Membranes
  • Non-Neoplastic Disorders of Skin
  • Tumors of the Aerodigestive Tract and Jaws
  • Tumors of the Bone Marrow
  • Tumors of the Central Nervous System
  • Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Vaterian System
  • Tumors of the Intestines
  • Tumors of the Liver
  • Tumors of the Lymph Nodes and Spleen
  • Tumors of the Mediastinum
  • Tumors of the Peripheral Nervous System
  • Tumors of the Soft Tissues
  • Tumors of the Thyroid and Parathyroid Glands



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